Pulmonary Intravascular Large B‐Cell Lymphoma Diagnosed by Transbronchial Lung Cryobiopsy: A Case Report
ABSTRACT Intravascular large B‐cell lymphoma (IVLBCL) is a rare and aggressive extranodal lymphoma characterised by the proliferation of malignant lymphocytes within the lumens of blood vessels. Diagnosing IVLBCL is often challenging due to its nonspecific clinical presentation and difficulty in obt...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-06-01
|
| Series: | Respirology Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/rcr2.70226 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849424926387208192 |
|---|---|
| author | Yen Shen Wong Hideaki Furuse Yuji Matsumoto Kenya Sato Takaaki Tsuchida |
| author_facet | Yen Shen Wong Hideaki Furuse Yuji Matsumoto Kenya Sato Takaaki Tsuchida |
| author_sort | Yen Shen Wong |
| collection | DOAJ |
| description | ABSTRACT Intravascular large B‐cell lymphoma (IVLBCL) is a rare and aggressive extranodal lymphoma characterised by the proliferation of malignant lymphocytes within the lumens of blood vessels. Diagnosing IVLBCL is often challenging due to its nonspecific clinical presentation and difficulty in obtaining histopathologic confirmation. Here, we present a case of IVLBCL diagnosed by transbronchial lung cryobiopsy (TBLC). A 68‐year‐old man was initially diagnosed with diffuse large B‐cell lymphoma based on an orchiectomy specimen. Although initial treatment achieved complete remission, tumour marker levels progressively increased during follow‐up. TBLC was performed after bone marrow biopsy, cerebrospinal fluid cytology, and a random skin biopsy failed to detect lymphoma lesions. Histological findings of the TBLC specimen demonstrated medium‐sized atypical lymphocytes filling the blood vessels, leading to a diagnosis of IVLBCL. Cryobiopsy specimens allow for the evaluation of alveolar structure and microvasculature, making it a valuable and less invasive diagnostic option for pulmonary IVLBCL. |
| format | Article |
| id | doaj-art-ddeae2bb0ea44a28a765fc282bd75264 |
| institution | Kabale University |
| issn | 2051-3380 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Respirology Case Reports |
| spelling | doaj-art-ddeae2bb0ea44a28a765fc282bd752642025-08-20T03:29:57ZengWileyRespirology Case Reports2051-33802025-06-01136n/an/a10.1002/rcr2.70226Pulmonary Intravascular Large B‐Cell Lymphoma Diagnosed by Transbronchial Lung Cryobiopsy: A Case ReportYen Shen Wong0Hideaki Furuse1Yuji Matsumoto2Kenya Sato3Takaaki Tsuchida4Department of Endoscopy, Respiratory Endoscopy Division National Cancer Center Hospital Tokyo JapanDepartment of Endoscopy, Respiratory Endoscopy Division National Cancer Center Hospital Tokyo JapanDepartment of Endoscopy, Respiratory Endoscopy Division National Cancer Center Hospital Tokyo JapanDepartment of Endoscopy, Respiratory Endoscopy Division National Cancer Center Hospital Tokyo JapanDepartment of Endoscopy, Respiratory Endoscopy Division National Cancer Center Hospital Tokyo JapanABSTRACT Intravascular large B‐cell lymphoma (IVLBCL) is a rare and aggressive extranodal lymphoma characterised by the proliferation of malignant lymphocytes within the lumens of blood vessels. Diagnosing IVLBCL is often challenging due to its nonspecific clinical presentation and difficulty in obtaining histopathologic confirmation. Here, we present a case of IVLBCL diagnosed by transbronchial lung cryobiopsy (TBLC). A 68‐year‐old man was initially diagnosed with diffuse large B‐cell lymphoma based on an orchiectomy specimen. Although initial treatment achieved complete remission, tumour marker levels progressively increased during follow‐up. TBLC was performed after bone marrow biopsy, cerebrospinal fluid cytology, and a random skin biopsy failed to detect lymphoma lesions. Histological findings of the TBLC specimen demonstrated medium‐sized atypical lymphocytes filling the blood vessels, leading to a diagnosis of IVLBCL. Cryobiopsy specimens allow for the evaluation of alveolar structure and microvasculature, making it a valuable and less invasive diagnostic option for pulmonary IVLBCL.https://doi.org/10.1002/rcr2.70226bronchoscopypulmonary intravascular large B‐cell lymphomatransbronchial lung cryobiopsy |
| spellingShingle | Yen Shen Wong Hideaki Furuse Yuji Matsumoto Kenya Sato Takaaki Tsuchida Pulmonary Intravascular Large B‐Cell Lymphoma Diagnosed by Transbronchial Lung Cryobiopsy: A Case Report Respirology Case Reports bronchoscopy pulmonary intravascular large B‐cell lymphoma transbronchial lung cryobiopsy |
| title | Pulmonary Intravascular Large B‐Cell Lymphoma Diagnosed by Transbronchial Lung Cryobiopsy: A Case Report |
| title_full | Pulmonary Intravascular Large B‐Cell Lymphoma Diagnosed by Transbronchial Lung Cryobiopsy: A Case Report |
| title_fullStr | Pulmonary Intravascular Large B‐Cell Lymphoma Diagnosed by Transbronchial Lung Cryobiopsy: A Case Report |
| title_full_unstemmed | Pulmonary Intravascular Large B‐Cell Lymphoma Diagnosed by Transbronchial Lung Cryobiopsy: A Case Report |
| title_short | Pulmonary Intravascular Large B‐Cell Lymphoma Diagnosed by Transbronchial Lung Cryobiopsy: A Case Report |
| title_sort | pulmonary intravascular large b cell lymphoma diagnosed by transbronchial lung cryobiopsy a case report |
| topic | bronchoscopy pulmonary intravascular large B‐cell lymphoma transbronchial lung cryobiopsy |
| url | https://doi.org/10.1002/rcr2.70226 |
| work_keys_str_mv | AT yenshenwong pulmonaryintravascularlargebcelllymphomadiagnosedbytransbronchiallungcryobiopsyacasereport AT hideakifuruse pulmonaryintravascularlargebcelllymphomadiagnosedbytransbronchiallungcryobiopsyacasereport AT yujimatsumoto pulmonaryintravascularlargebcelllymphomadiagnosedbytransbronchiallungcryobiopsyacasereport AT kenyasato pulmonaryintravascularlargebcelllymphomadiagnosedbytransbronchiallungcryobiopsyacasereport AT takaakitsuchida pulmonaryintravascularlargebcelllymphomadiagnosedbytransbronchiallungcryobiopsyacasereport |