Neuroendocrine tumors of the vagina
The paper covers the most important topographic-anatomic and histological characteristics of the vagina, gives general information on the epidemiology of primary vaginal cancer (VC), on the rules of its staging, describes the frequently encountered morphological types of this tumor, and indicates th...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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ABV-press
2015-09-01
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| Series: | Опухоли женской репродуктивной системы |
| Subjects: | |
| Online Access: | https://ojrs.abvpress.ru/ojrs/article/view/451 |
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| author | S. O. Nikogosyan T. Sh. Tagibova O. A. Anurova A. A. Markovich L. I. Korolenkova V. V. Kuznetsov |
| author_facet | S. O. Nikogosyan T. Sh. Tagibova O. A. Anurova A. A. Markovich L. I. Korolenkova V. V. Kuznetsov |
| author_sort | S. O. Nikogosyan |
| collection | DOAJ |
| description | The paper covers the most important topographic-anatomic and histological characteristics of the vagina, gives general information on the epidemiology of primary vaginal cancer (VC), on the rules of its staging, describes the frequently encountered morphological types of this tumor, and indicates the properties and features of the course of neuroendocrine tumors (NETs), including the most common manifestations of carcinoid syndrome and the symptoms of tumor hypersecretion of a number of biologically active substances. It also indicates the most common sites of NETs, the rules of their classification according to the grade and mitotic activity of tumor cells, as well as major methods for biochemical and radiological diagnosis. The immunohistochemical NET markers that can diagnose VC, their physiological role, sensitivity, and specificity, as well as the possibility of determining them in the body’s biological environments in order to increase physicians’ awareness are described in detail and the main aspects of tumor immunohistochemical staining are denoted. The role of circulating tumor cells as a promising method to specify the extent of NETs is defined. The paper gives epidemiological information on the development of vaginal NET and summarizes the available data by their clinical course and treatment results. It provides current guidelines on the required treatment volume and specifies the role of surgical intervention and the necessary volume if the intervention is expedient. It sets forth the up-to-date guidelines for chemotherapy for small cell tumors, as well as VC, which includes the specific features of managing patients with tumor recurrences depending on the time of their development. |
| format | Article |
| id | doaj-art-ddea1c9dfcfa4d17a6fd8c2f7079769f |
| institution | DOAJ |
| issn | 1994-4098 1999-8627 |
| language | Russian |
| publishDate | 2015-09-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли женской репродуктивной системы |
| spelling | doaj-art-ddea1c9dfcfa4d17a6fd8c2f7079769f2025-08-20T03:01:59ZrusABV-pressОпухоли женской репродуктивной системы1994-40981999-86272015-09-01113768610.17650/1994-4098-2015-11-3-76-86464Neuroendocrine tumors of the vaginaS. O. Nikogosyan0T. Sh. Tagibova1O. A. Anurova2A. A. Markovich3L. I. Korolenkova4V. V. Kuznetsov5N.N. Blokhin Russian Cancer Research Center; 23 Kashirskoe Shosse, Moscow, 115478, RussiaN.N. Blokhin Russian Cancer Research Center; 23 Kashirskoe Shosse, Moscow, 115478, RussiaN.N. Blokhin Russian Cancer Research Center; 23 Kashirskoe Shosse, Moscow, 115478, RussiaN.N. Blokhin Russian Cancer Research Center; 23 Kashirskoe Shosse, Moscow, 115478, RussiaN.N. Blokhin Russian Cancer Research Center; 23 Kashirskoe Shosse, Moscow, 115478, RussiaN.N. Blokhin Russian Cancer Research Center; 23 Kashirskoe Shosse, Moscow, 115478, RussiaThe paper covers the most important topographic-anatomic and histological characteristics of the vagina, gives general information on the epidemiology of primary vaginal cancer (VC), on the rules of its staging, describes the frequently encountered morphological types of this tumor, and indicates the properties and features of the course of neuroendocrine tumors (NETs), including the most common manifestations of carcinoid syndrome and the symptoms of tumor hypersecretion of a number of biologically active substances. It also indicates the most common sites of NETs, the rules of their classification according to the grade and mitotic activity of tumor cells, as well as major methods for biochemical and radiological diagnosis. The immunohistochemical NET markers that can diagnose VC, their physiological role, sensitivity, and specificity, as well as the possibility of determining them in the body’s biological environments in order to increase physicians’ awareness are described in detail and the main aspects of tumor immunohistochemical staining are denoted. The role of circulating tumor cells as a promising method to specify the extent of NETs is defined. The paper gives epidemiological information on the development of vaginal NET and summarizes the available data by their clinical course and treatment results. It provides current guidelines on the required treatment volume and specifies the role of surgical intervention and the necessary volume if the intervention is expedient. It sets forth the up-to-date guidelines for chemotherapy for small cell tumors, as well as VC, which includes the specific features of managing patients with tumor recurrences depending on the time of their development.https://ojrs.abvpress.ru/ojrs/article/view/451vaginal cancerneuroendocrine tumorssmall cell carcinomacarcinoid syndromechromograninsynaptophysinserotonincirculating tumor cellscyclooxygenaseneuron-specific enolasetreatment for small cell carcinomachemotherapy |
| spellingShingle | S. O. Nikogosyan T. Sh. Tagibova O. A. Anurova A. A. Markovich L. I. Korolenkova V. V. Kuznetsov Neuroendocrine tumors of the vagina Опухоли женской репродуктивной системы vaginal cancer neuroendocrine tumors small cell carcinoma carcinoid syndrome chromogranin synaptophysin serotonin circulating tumor cells cyclooxygenase neuron-specific enolase treatment for small cell carcinoma chemotherapy |
| title | Neuroendocrine tumors of the vagina |
| title_full | Neuroendocrine tumors of the vagina |
| title_fullStr | Neuroendocrine tumors of the vagina |
| title_full_unstemmed | Neuroendocrine tumors of the vagina |
| title_short | Neuroendocrine tumors of the vagina |
| title_sort | neuroendocrine tumors of the vagina |
| topic | vaginal cancer neuroendocrine tumors small cell carcinoma carcinoid syndrome chromogranin synaptophysin serotonin circulating tumor cells cyclooxygenase neuron-specific enolase treatment for small cell carcinoma chemotherapy |
| url | https://ojrs.abvpress.ru/ojrs/article/view/451 |
| work_keys_str_mv | AT sonikogosyan neuroendocrinetumorsofthevagina AT tshtagibova neuroendocrinetumorsofthevagina AT oaanurova neuroendocrinetumorsofthevagina AT aamarkovich neuroendocrinetumorsofthevagina AT likorolenkova neuroendocrinetumorsofthevagina AT vvkuznetsov neuroendocrinetumorsofthevagina |