Exploring Clinical and Imaging Differences in COVID-19: an Observational Approach to the IFITM3 rs12252 Polymorphism
Adriana Mitrea,1,2 Anca-Florentina Mitroi,3,4 Cristian Opariuc-Dan,5 Ancuta-Alina Constantin,6,7 Elena Dantes8,9 1Doctoral School of Medicine, “Ovidius” University of Constanta, Constanta, Romania; 2Department of Pulmonology, “Sf. Apostol Andrei” Emergency Clinical County Hospital of Constanta, Cons...
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Dove Medical Press
2025-04-01
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| author | Mitrea A Mitroi AF Opariuc-Dan C Constantin AA Dantes E |
| author_facet | Mitrea A Mitroi AF Opariuc-Dan C Constantin AA Dantes E |
| author_sort | Mitrea A |
| collection | DOAJ |
| description | Adriana Mitrea,1,2 Anca-Florentina Mitroi,3,4 Cristian Opariuc-Dan,5 Ancuta-Alina Constantin,6,7 Elena Dantes8,9 1Doctoral School of Medicine, “Ovidius” University of Constanta, Constanta, Romania; 2Department of Pulmonology, “Sf. Apostol Andrei” Emergency Clinical County Hospital of Constanta, Constanta, Romania; 3Pathology Department, “Sf. Apostol Andrei” Emergency Clinical County Hospital of Constanta, Constanta, Romania; 4CEDMOG Center, “Ovidius” University of Constanta, Constanta, Romania; 5Faculty of Law and Administrative Science, “Ovidius” University of Constanta, Constanta, Romania; 6Department of Cardio-Thoracic Pathology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania; 7Department of Cardio-Thoracic Pathology, Institute of Pneumology “Marius Nasta”, Bucharest, Romania; 8Faculty of Medicine, ‘Ovidius’ University of Constanta, Constanta, Romania; 9 1st Pneumology Department, Clinical Hospital of Pneumophtisiology, Constanta, RomaniaCorrespondence: Anca-Florentina Mitroi, Pathology Department, “Sf. Apostol Andrei” Emergency Clinical County Hospital of Constanta, 145 Tomis Blv, Constanta, Romania, Email anca.mitroi@365.univ-ovidius.roPurpose: The severity of COVID-19 infections varies among individuals, prompting research into factors that may influence outcomes. Numerous studies have investigated the conditions that influence the intensity of illness caused by COVID-19. These factors include the Interferon-Induced Transmembrane Protein 3 (IFITM3) rs12252 polymorphism. We investigate whether the polymorphism rs12252 plays a role within our population and observe the differences in other parameters between the mild and severe forms of the disease.Patients and Methods: The observational study examining the IFTIM3 rs12252 polymorphism based on the level of COVID-19 severity and differences between inflammatory markers. The study included 51 participants, with 31 severe and 20 mild cases.Results: The average age of participants was 54 years, and 16.1% of patients with severe symptoms were diagnosed with the AG genotype. Patients showing serious symptoms had significantly higher ESR, CRP, Fibrinogen, LDH, and D-dimer levels than those with mild symptoms.Conclusion: This study discovered a notable correlation between the G allele of IFITM3 rs12252, inflammatory markers, CT scan score, and COVID-19 severity.Keywords: COVID-19, IFITM3 protein, inflammatory markers, genotype |
| format | Article |
| id | doaj-art-dde7d709fa8244eab88e4a794655c65e |
| institution | OA Journals |
| issn | 1178-7074 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Dove Medical Press |
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| series | International Journal of General Medicine |
| spelling | doaj-art-dde7d709fa8244eab88e4a794655c65e2025-08-20T02:16:49ZengDove Medical PressInternational Journal of General Medicine1178-70742025-04-01Volume 1820772091101959Exploring Clinical and Imaging Differences in COVID-19: an Observational Approach to the IFITM3 rs12252 PolymorphismMitrea AMitroi AFOpariuc-Dan CConstantin AADantes EAdriana Mitrea,1,2 Anca-Florentina Mitroi,3,4 Cristian Opariuc-Dan,5 Ancuta-Alina Constantin,6,7 Elena Dantes8,9 1Doctoral School of Medicine, “Ovidius” University of Constanta, Constanta, Romania; 2Department of Pulmonology, “Sf. Apostol Andrei” Emergency Clinical County Hospital of Constanta, Constanta, Romania; 3Pathology Department, “Sf. Apostol Andrei” Emergency Clinical County Hospital of Constanta, Constanta, Romania; 4CEDMOG Center, “Ovidius” University of Constanta, Constanta, Romania; 5Faculty of Law and Administrative Science, “Ovidius” University of Constanta, Constanta, Romania; 6Department of Cardio-Thoracic Pathology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania; 7Department of Cardio-Thoracic Pathology, Institute of Pneumology “Marius Nasta”, Bucharest, Romania; 8Faculty of Medicine, ‘Ovidius’ University of Constanta, Constanta, Romania; 9 1st Pneumology Department, Clinical Hospital of Pneumophtisiology, Constanta, RomaniaCorrespondence: Anca-Florentina Mitroi, Pathology Department, “Sf. Apostol Andrei” Emergency Clinical County Hospital of Constanta, 145 Tomis Blv, Constanta, Romania, Email anca.mitroi@365.univ-ovidius.roPurpose: The severity of COVID-19 infections varies among individuals, prompting research into factors that may influence outcomes. Numerous studies have investigated the conditions that influence the intensity of illness caused by COVID-19. These factors include the Interferon-Induced Transmembrane Protein 3 (IFITM3) rs12252 polymorphism. We investigate whether the polymorphism rs12252 plays a role within our population and observe the differences in other parameters between the mild and severe forms of the disease.Patients and Methods: The observational study examining the IFTIM3 rs12252 polymorphism based on the level of COVID-19 severity and differences between inflammatory markers. The study included 51 participants, with 31 severe and 20 mild cases.Results: The average age of participants was 54 years, and 16.1% of patients with severe symptoms were diagnosed with the AG genotype. Patients showing serious symptoms had significantly higher ESR, CRP, Fibrinogen, LDH, and D-dimer levels than those with mild symptoms.Conclusion: This study discovered a notable correlation between the G allele of IFITM3 rs12252, inflammatory markers, CT scan score, and COVID-19 severity.Keywords: COVID-19, IFITM3 protein, inflammatory markers, genotypehttps://www.dovepress.com/exploring-clinical-and-imaging-differences-in-covid-19-an-observationa-peer-reviewed-fulltext-article-IJGMcovid-19ifitm3 proteininflammatory markersgenotype. |
| spellingShingle | Mitrea A Mitroi AF Opariuc-Dan C Constantin AA Dantes E Exploring Clinical and Imaging Differences in COVID-19: an Observational Approach to the IFITM3 rs12252 Polymorphism International Journal of General Medicine covid-19 ifitm3 protein inflammatory markers genotype. |
| title | Exploring Clinical and Imaging Differences in COVID-19: an Observational Approach to the IFITM3 rs12252 Polymorphism |
| title_full | Exploring Clinical and Imaging Differences in COVID-19: an Observational Approach to the IFITM3 rs12252 Polymorphism |
| title_fullStr | Exploring Clinical and Imaging Differences in COVID-19: an Observational Approach to the IFITM3 rs12252 Polymorphism |
| title_full_unstemmed | Exploring Clinical and Imaging Differences in COVID-19: an Observational Approach to the IFITM3 rs12252 Polymorphism |
| title_short | Exploring Clinical and Imaging Differences in COVID-19: an Observational Approach to the IFITM3 rs12252 Polymorphism |
| title_sort | exploring clinical and imaging differences in covid 19 an observational approach to the ifitm3 rs12252 polymorphism |
| topic | covid-19 ifitm3 protein inflammatory markers genotype. |
| url | https://www.dovepress.com/exploring-clinical-and-imaging-differences-in-covid-19-an-observationa-peer-reviewed-fulltext-article-IJGM |
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