Improvement of End-of-Synthesis Radiochemical Purity of <sup>177</sup>Lu-DOTA-PSMA-Ligands with Alternative Synthesis Approaches: Conversion Upswing and Side-Products Minimization

Improvement of End-of-Synthesis Radiochemical Purity of <sup>177</sup>Lu-DOTA-PSMA-Ligands with Alternative Synthesis Approaches: Conversion Upswing and Side-Products Minimization

Background: Radiochemical purity is a key criterion for the quality of radiopharmaceuticals used in clinical practice. The joint improvement of analytical methods capable of identifying related radiochemical impurities and determining the actual radiochemical purity, as well as the improvement of sy...

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Bibliographic Details
Main Authors: Anton Larenkov, Iurii Mitrofanov, Marat Rakhimov
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Pharmaceutics
Subjects:
lutetium-177
DOTA
PSMA
[<sup>177</sup>Lu]Lu-PSMA-617
radiochemical yield
radiochemical purity
Online Access:https://www.mdpi.com/1999-4923/16/12/1535
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