Effect on Polysaccharide Krestin from Coriolus versicolor Extract on Phagocytic Activity and Capacity of Mus musculus Exposed by Pseudomonas aeruginosa
<p><em>Pseudomonas aeruginosa </em>is an opportunistic bacterium that causes infections in human. The wall cell of its bacteria contains lipopolysaccharide as virulency factors to protect it from human immunity. Lipopolysaccharide can inhibit phagocytosis in the body. Polysaccharid...
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Universitas Negeri Semarang
2016-11-01
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| Series: | Biosaintifika: Journal of Biology & Biology Education |
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| Online Access: | https://journal.unnes.ac.id/nju/index.php/biosaintifika/article/view/6957 |
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| author | Sri Puji Astuti Wahyuningsih Nadyatul Ilma Indah Savira Win Darmanto |
| author_facet | Sri Puji Astuti Wahyuningsih Nadyatul Ilma Indah Savira Win Darmanto |
| author_sort | Sri Puji Astuti Wahyuningsih |
| collection | DOAJ |
| description | <p><em>Pseudomonas aeruginosa </em>is an opportunistic bacterium that causes infections in human. The wall cell of its bacteria contains lipopolysaccharide as virulency factors to protect it from human immunity. Lipopolysaccharide can inhibit phagocytosis in the body. Polysaccharide krestin (PSK) from <em>Coriolus versicolor </em>extract contains β-glucan that can increase phagocytic activity and capacity. This research aimed to identify the effect on polysaccharide krestin from <em>C. versicolor</em> extract on phagocytic activity and capacity of mice exposed by <em>P. aeruginosa</em>. The design of this research was experimental design. There were six treatment groups. The phagocytic activity and capacity were counted on slide smears of mice peritoneal fluid. The data was analyzed by using one way ANOVA. The results of the phagocytic activity and capacity showed that PSK was added before exposure (P1) or after exposure (P2) or before-after exposure (P3) had potential to increase phagocytic activity and capacity. The conclusion of the research was that adding polysaccharide krestin either before exposure or after exposure or both of them could increase phagocytic activity and capacity. The benefits of this research to development of science are expected to reduce human infection and to utilize natural ingredients as immunomodulator.</p><p><strong>How to Cite</strong></p><p>Wahyuningsih, S. P. A., Savira, N. I. I, & Darmanto, W. (2016). Effect on Polysaccharide Krestin from Coriolus versicolor Extract on Phagocytic Activity and Capacity of Mus musculus Exposed by <em>Pseudomonas aeruginosa</em>. <em>Biosaintifika: Journal of Biology & Biology Education</em>, 8(3), 308-313. </p> |
| format | Article |
| id | doaj-art-dde05a0fef8343f2a373746cd5cf884b |
| institution | Kabale University |
| issn | 2085-191X 2338-7610 |
| language | English |
| publishDate | 2016-11-01 |
| publisher | Universitas Negeri Semarang |
| record_format | Article |
| series | Biosaintifika: Journal of Biology & Biology Education |
| spelling | doaj-art-dde05a0fef8343f2a373746cd5cf884b2025-08-20T03:24:40ZengUniversitas Negeri SemarangBiosaintifika: Journal of Biology & Biology Education2085-191X2338-76102016-11-018330831310.15294/biosaintifika.v8i3.69575201Effect on Polysaccharide Krestin from Coriolus versicolor Extract on Phagocytic Activity and Capacity of Mus musculus Exposed by Pseudomonas aeruginosaSri Puji Astuti Wahyuningsih0Nadyatul Ilma Indah Savira1Win Darmanto2Departement of Biology, Faculty of Science and Technology, Airlangga University, IndonesiaDepartement of Biology, Faculty of Science and Technology, Airlangga University, IndonesiaDepartement of Biology, Faculty of Science and Technology, Airlangga University, Indonesia<p><em>Pseudomonas aeruginosa </em>is an opportunistic bacterium that causes infections in human. The wall cell of its bacteria contains lipopolysaccharide as virulency factors to protect it from human immunity. Lipopolysaccharide can inhibit phagocytosis in the body. Polysaccharide krestin (PSK) from <em>Coriolus versicolor </em>extract contains β-glucan that can increase phagocytic activity and capacity. This research aimed to identify the effect on polysaccharide krestin from <em>C. versicolor</em> extract on phagocytic activity and capacity of mice exposed by <em>P. aeruginosa</em>. The design of this research was experimental design. There were six treatment groups. The phagocytic activity and capacity were counted on slide smears of mice peritoneal fluid. The data was analyzed by using one way ANOVA. The results of the phagocytic activity and capacity showed that PSK was added before exposure (P1) or after exposure (P2) or before-after exposure (P3) had potential to increase phagocytic activity and capacity. The conclusion of the research was that adding polysaccharide krestin either before exposure or after exposure or both of them could increase phagocytic activity and capacity. The benefits of this research to development of science are expected to reduce human infection and to utilize natural ingredients as immunomodulator.</p><p><strong>How to Cite</strong></p><p>Wahyuningsih, S. P. A., Savira, N. I. I, & Darmanto, W. (2016). Effect on Polysaccharide Krestin from Coriolus versicolor Extract on Phagocytic Activity and Capacity of Mus musculus Exposed by <em>Pseudomonas aeruginosa</em>. <em>Biosaintifika: Journal of Biology & Biology Education</em>, 8(3), 308-313. </p>https://journal.unnes.ac.id/nju/index.php/biosaintifika/article/view/6957Polysaccharide krestinphagocytic activityphagocytic capacity |
| spellingShingle | Sri Puji Astuti Wahyuningsih Nadyatul Ilma Indah Savira Win Darmanto Effect on Polysaccharide Krestin from Coriolus versicolor Extract on Phagocytic Activity and Capacity of Mus musculus Exposed by Pseudomonas aeruginosa Biosaintifika: Journal of Biology & Biology Education Polysaccharide krestin phagocytic activity phagocytic capacity |
| title | Effect on Polysaccharide Krestin from Coriolus versicolor Extract on Phagocytic Activity and Capacity of Mus musculus Exposed by Pseudomonas aeruginosa |
| title_full | Effect on Polysaccharide Krestin from Coriolus versicolor Extract on Phagocytic Activity and Capacity of Mus musculus Exposed by Pseudomonas aeruginosa |
| title_fullStr | Effect on Polysaccharide Krestin from Coriolus versicolor Extract on Phagocytic Activity and Capacity of Mus musculus Exposed by Pseudomonas aeruginosa |
| title_full_unstemmed | Effect on Polysaccharide Krestin from Coriolus versicolor Extract on Phagocytic Activity and Capacity of Mus musculus Exposed by Pseudomonas aeruginosa |
| title_short | Effect on Polysaccharide Krestin from Coriolus versicolor Extract on Phagocytic Activity and Capacity of Mus musculus Exposed by Pseudomonas aeruginosa |
| title_sort | effect on polysaccharide krestin from coriolus versicolor extract on phagocytic activity and capacity of mus musculus exposed by pseudomonas aeruginosa |
| topic | Polysaccharide krestin phagocytic activity phagocytic capacity |
| url | https://journal.unnes.ac.id/nju/index.php/biosaintifika/article/view/6957 |
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