Influence of immunocorrective remedies on changes of cytokine profile in conditions of the course administration of doxorubicine
It is found that Amixin, Imunofan and Polyoxidonium reduce the depth of suppression of humoral immune response and cytokine profile disorder in conditions of the course administration of doxorubicine. Amixin more active corrects changes of IFN-γ, IL-4, IL-6 contents, while Imunofan and especially Po...
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Zaporizhzhia State Medical and Pharmaceutical University
2013-04-01
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| Series: | Zaporožskij Medicinskij Žurnal |
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| Online Access: | http://zmj.zsmu.edu.ua/article/view/15593/13393 |
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| author | E. P. Moskvichov |
| author_facet | E. P. Moskvichov |
| author_sort | E. P. Moskvichov |
| collection | DOAJ |
| description | It is found that Amixin, Imunofan and Polyoxidonium reduce the depth of suppression of humoral immune response and cytokine profile disorder in conditions of the course administration of doxorubicine. Amixin more active corrects changes of IFN-γ, IL-4, IL-6 contents, while Imunofan and especially Polyoxidonium more effectively contribute to the stabilization of IL-2 and IL-6 contents, which is apparently associated with effect on different target cells and the characteristics of the molecular mechanisms of action of each of the drugs. |
| format | Article |
| id | doaj-art-dddcffb9beb042698eff19810a242fd4 |
| institution | OA Journals |
| issn | 2306-4145 2310-1210 |
| language | English |
| publishDate | 2013-04-01 |
| publisher | Zaporizhzhia State Medical and Pharmaceutical University |
| record_format | Article |
| series | Zaporožskij Medicinskij Žurnal |
| spelling | doaj-art-dddcffb9beb042698eff19810a242fd42025-08-20T02:04:09ZengZaporizhzhia State Medical and Pharmaceutical UniversityZaporožskij Medicinskij Žurnal2306-41452310-12102013-04-0123235http://dx.doi.org/10.14739/2310-1210.2013.2.15593Influence of immunocorrective remedies on changes of cytokine profile in conditions of the course administration of doxorubicineE. P. MoskvichovIt is found that Amixin, Imunofan and Polyoxidonium reduce the depth of suppression of humoral immune response and cytokine profile disorder in conditions of the course administration of doxorubicine. Amixin more active corrects changes of IFN-γ, IL-4, IL-6 contents, while Imunofan and especially Polyoxidonium more effectively contribute to the stabilization of IL-2 and IL-6 contents, which is apparently associated with effect on different target cells and the characteristics of the molecular mechanisms of action of each of the drugs.http://zmj.zsmu.edu.ua/article/view/15593/13393doxorubicine-induced immunosuppressionAmixinImunofanPolyoxidoniumcytokine profile |
| spellingShingle | E. P. Moskvichov Influence of immunocorrective remedies on changes of cytokine profile in conditions of the course administration of doxorubicine Zaporožskij Medicinskij Žurnal doxorubicine-induced immunosuppression Amixin Imunofan Polyoxidonium cytokine profile |
| title | Influence of immunocorrective remedies on changes of cytokine profile in conditions of the course administration of doxorubicine |
| title_full | Influence of immunocorrective remedies on changes of cytokine profile in conditions of the course administration of doxorubicine |
| title_fullStr | Influence of immunocorrective remedies on changes of cytokine profile in conditions of the course administration of doxorubicine |
| title_full_unstemmed | Influence of immunocorrective remedies on changes of cytokine profile in conditions of the course administration of doxorubicine |
| title_short | Influence of immunocorrective remedies on changes of cytokine profile in conditions of the course administration of doxorubicine |
| title_sort | influence of immunocorrective remedies on changes of cytokine profile in conditions of the course administration of doxorubicine |
| topic | doxorubicine-induced immunosuppression Amixin Imunofan Polyoxidonium cytokine profile |
| url | http://zmj.zsmu.edu.ua/article/view/15593/13393 |
| work_keys_str_mv | AT epmoskvichov influenceofimmunocorrectiveremediesonchangesofcytokineprofileinconditionsofthecourseadministrationofdoxorubicine |