Calcium signaling in postsynaptic mitochondria: mechanisms, dynamics, and role in ATP production

Calcium signaling in postsynaptic mitochondria: mechanisms, dynamics, and role in ATP production

While the overall ATP level in neurons remains relatively stable, local fluctuations in synaptic compartments - driven by synaptic potentials - necessitate rapid ATP adjustments. The energy supply for synaptic activity in neurons must be under precise homeostatic control: increased ATP consumption i...

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Bibliographic Details
Main Authors: Tatiana Feofilaktova, Liliia Kushnireva, Menahem Segal, Eduard Korkotian
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Molecular Neuroscience
Subjects:
mitochondria
mitophagy
dendritic spine
ATP synthase
endoplasmic reticulum
MCU
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2025.1621070/full
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