IUPHAR review: Microbiota-gut-brain axis and its role in neuropsychiatric disorders
The human gut microbiome, composed of a vast array of microorganisms that have co-evolved with humans, is crucial for the development and function of brain systems. Research has consistently shown bidirectional communication between the gut and the brain through neuronal, endocrine, and immunologica...
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Elsevier
2025-06-01
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| Series: | Pharmacological Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1043661825001744 |
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| author | Seung-Hoon Lee Changsu Han Cheolmin Shin |
| author_facet | Seung-Hoon Lee Changsu Han Cheolmin Shin |
| author_sort | Seung-Hoon Lee |
| collection | DOAJ |
| description | The human gut microbiome, composed of a vast array of microorganisms that have co-evolved with humans, is crucial for the development and function of brain systems. Research has consistently shown bidirectional communication between the gut and the brain through neuronal, endocrine, and immunological, and chemical pathways. Recent neuroscience studies have linked changes in the microbiome and microbial metabolites to various neuropsychiatric disorders such as autism, depression, anxiety, schizophrenia, eating disorders, and neurocognitive disorders. Novel metagenome-wide association studies have confirmed these microbiome variations in large samples and expanded our understanding of the interactions between human genes and the gut microbiome. The causal relationship between gut microbiota and neuropsychiatric disorders is being elucidated through the establishment of large cohort studies incorporating microbiome data and advanced statistical techniques. Ongoing animal and human studies focused on the microbiota-gut-brain axis are promising for developing new prevention and treatment strategies for neuropsychiatric conditions. The scope of these studies has broadened from microbiome-modulating therapies including prebiotics, probiotics, synbiotics and postbiotics to more extensive approaches such as fecal microbiota transplantation. Recent systematic reviews and meta-analyses have strengthened the evidence base for these innovative treatments. Despite extensive research over the past decade, many intriguing aspects still need to be elucidated regarding the role and therapeutic interventions of the microbiota-gut-brain axis in neuropsychiatric disorders. |
| format | Article |
| id | doaj-art-ddd8907ebbca4f8098f715da33e16ac7 |
| institution | Kabale University |
| issn | 1096-1186 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research |
| spelling | doaj-art-ddd8907ebbca4f8098f715da33e16ac72025-08-20T03:25:59ZengElsevierPharmacological Research1096-11862025-06-0121610774910.1016/j.phrs.2025.107749IUPHAR review: Microbiota-gut-brain axis and its role in neuropsychiatric disordersSeung-Hoon Lee0Changsu Han1Cheolmin Shin2Department of Psychiatry, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Republic of KoreaDepartment of Psychiatry, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Republic of KoreaDepartment of Psychiatry, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Republic of Korea; Correspondence to: Department of Psychiatry, College of Medicine, Korea University, Ansan Hospital, 123, Jeokgeum-ro, Danwon-gu, Ansan-si 15355, Republic of Korea.The human gut microbiome, composed of a vast array of microorganisms that have co-evolved with humans, is crucial for the development and function of brain systems. Research has consistently shown bidirectional communication between the gut and the brain through neuronal, endocrine, and immunological, and chemical pathways. Recent neuroscience studies have linked changes in the microbiome and microbial metabolites to various neuropsychiatric disorders such as autism, depression, anxiety, schizophrenia, eating disorders, and neurocognitive disorders. Novel metagenome-wide association studies have confirmed these microbiome variations in large samples and expanded our understanding of the interactions between human genes and the gut microbiome. The causal relationship between gut microbiota and neuropsychiatric disorders is being elucidated through the establishment of large cohort studies incorporating microbiome data and advanced statistical techniques. Ongoing animal and human studies focused on the microbiota-gut-brain axis are promising for developing new prevention and treatment strategies for neuropsychiatric conditions. The scope of these studies has broadened from microbiome-modulating therapies including prebiotics, probiotics, synbiotics and postbiotics to more extensive approaches such as fecal microbiota transplantation. Recent systematic reviews and meta-analyses have strengthened the evidence base for these innovative treatments. Despite extensive research over the past decade, many intriguing aspects still need to be elucidated regarding the role and therapeutic interventions of the microbiota-gut-brain axis in neuropsychiatric disorders.http://www.sciencedirect.com/science/article/pii/S1043661825001744Microbiota-gut-brain axisGut-brain axisGut microbiomeNeuropsychiatric disordersProbioticsFecal microbiota transplantation |
| spellingShingle | Seung-Hoon Lee Changsu Han Cheolmin Shin IUPHAR review: Microbiota-gut-brain axis and its role in neuropsychiatric disorders Pharmacological Research Microbiota-gut-brain axis Gut-brain axis Gut microbiome Neuropsychiatric disorders Probiotics Fecal microbiota transplantation |
| title | IUPHAR review: Microbiota-gut-brain axis and its role in neuropsychiatric disorders |
| title_full | IUPHAR review: Microbiota-gut-brain axis and its role in neuropsychiatric disorders |
| title_fullStr | IUPHAR review: Microbiota-gut-brain axis and its role in neuropsychiatric disorders |
| title_full_unstemmed | IUPHAR review: Microbiota-gut-brain axis and its role in neuropsychiatric disorders |
| title_short | IUPHAR review: Microbiota-gut-brain axis and its role in neuropsychiatric disorders |
| title_sort | iuphar review microbiota gut brain axis and its role in neuropsychiatric disorders |
| topic | Microbiota-gut-brain axis Gut-brain axis Gut microbiome Neuropsychiatric disorders Probiotics Fecal microbiota transplantation |
| url | http://www.sciencedirect.com/science/article/pii/S1043661825001744 |
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