Ribonuclease 1 Induces T‐Cell Dysfunction and Impairs CD8+ T‐Cell Cytotoxicity to Benefit Tumor Growth through Hijacking STAT1

Ribonuclease 1 Induces T‐Cell Dysfunction and Impairs CD8+ T‐Cell Cytotoxicity to Benefit Tumor Growth through Hijacking STAT1

Abstract T‐cell‐based immunotherapy holds promise for eliminating cancer through T‐cell activation. However, prolonged interaction between T cells and tumors and the presence of immunosuppressive factors can diminish T‐cell cytotoxicity, leading to treatment failure. Here, ribonuclease 1 (RNase1), w...

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Main Authors: Wen‐Hao Yang, Bao‐Yue Huang, Hsing‐Yu Rao, Peng Ye, Bi Chen, Hao‐Ching Wang, Chih‐Hung Chung, Heng‐Hsiung Wu, Hung‐Rong Yen, Shao‐Chun Wang, Jong‐Ho Cha, Xiuwen Yan, Muh‐Hwa Yang, Mien‐Chie Hung
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Advanced Science
Subjects:
effector cytokine
immune checkpoint protein
ribonuclease 1
STAT1
T‐cell dysfunction
Online Access:https://doi.org/10.1002/advs.202404961
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