Chronic Neuropsychological Sequelae in a Patient with Nontumorous Anti-NMDA-Receptor Encephalitis

Anti-N-methyl-D-aspartate receptor encephalitis is a neurological, autoimmune disorder tightly conceptualized only as recently as the mid-2000s. It presents itself in a combination of psychiatric, neurological, and autonomic features. We observe a unique case with probable earlier episode (prior to...

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Main Authors: Dong Y. Han, Lisa M. Koehl, Aarti Patel, Zhengqiu Zhou, Sarah Phillips, Siddharth Kapoor
Format: Article
Language:English
Published: Wiley 2017-01-01
Series:Case Reports in Neurological Medicine
Online Access:http://dx.doi.org/10.1155/2017/5675732
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author Dong Y. Han
Lisa M. Koehl
Aarti Patel
Zhengqiu Zhou
Sarah Phillips
Siddharth Kapoor
author_facet Dong Y. Han
Lisa M. Koehl
Aarti Patel
Zhengqiu Zhou
Sarah Phillips
Siddharth Kapoor
author_sort Dong Y. Han
collection DOAJ
description Anti-N-methyl-D-aspartate receptor encephalitis is a neurological, autoimmune disorder tightly conceptualized only as recently as the mid-2000s. It presents itself in a combination of psychiatric, neurological, and autonomic features. We observe a unique case with probable earlier episode (prior to the mid-2000s conceptualization of the disease) and a later relapse, accompanying a comprehensive neuropsychological profile tracked after the relapse and subsequent improvement. Neurocognitive findings revealed residual frontal deficits with mood changes even in the state after plasmapheresis. This case is the first to describe posttreatment cognition in anti-NMDAR encephalitis after probable serial autoimmune episodes.
format Article
id doaj-art-ddd26540931f4475acc43e994aa5d9e5
institution OA Journals
issn 2090-6668
2090-6676
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publishDate 2017-01-01
publisher Wiley
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series Case Reports in Neurological Medicine
spelling doaj-art-ddd26540931f4475acc43e994aa5d9e52025-08-20T02:21:33ZengWileyCase Reports in Neurological Medicine2090-66682090-66762017-01-01201710.1155/2017/56757325675732Chronic Neuropsychological Sequelae in a Patient with Nontumorous Anti-NMDA-Receptor EncephalitisDong Y. Han0Lisa M. Koehl1Aarti Patel2Zhengqiu Zhou3Sarah Phillips4Siddharth Kapoor5Department of Neurology, University of Kentucky College of Medicine, Lexington, KY, USADepartment of Neurology, University of Kentucky College of Medicine, Lexington, KY, USADepartment of Psychiatry, University of Kentucky College of Medicine, Lexington, KY, USADepartment of Neurology, University of Kentucky College of Medicine, Lexington, KY, USADepartment of Neurology, University of Kentucky College of Medicine, Lexington, KY, USADepartment of Neurology, University of Kentucky College of Medicine, Lexington, KY, USAAnti-N-methyl-D-aspartate receptor encephalitis is a neurological, autoimmune disorder tightly conceptualized only as recently as the mid-2000s. It presents itself in a combination of psychiatric, neurological, and autonomic features. We observe a unique case with probable earlier episode (prior to the mid-2000s conceptualization of the disease) and a later relapse, accompanying a comprehensive neuropsychological profile tracked after the relapse and subsequent improvement. Neurocognitive findings revealed residual frontal deficits with mood changes even in the state after plasmapheresis. This case is the first to describe posttreatment cognition in anti-NMDAR encephalitis after probable serial autoimmune episodes.http://dx.doi.org/10.1155/2017/5675732
spellingShingle Dong Y. Han
Lisa M. Koehl
Aarti Patel
Zhengqiu Zhou
Sarah Phillips
Siddharth Kapoor
Chronic Neuropsychological Sequelae in a Patient with Nontumorous Anti-NMDA-Receptor Encephalitis
Case Reports in Neurological Medicine
title Chronic Neuropsychological Sequelae in a Patient with Nontumorous Anti-NMDA-Receptor Encephalitis
title_full Chronic Neuropsychological Sequelae in a Patient with Nontumorous Anti-NMDA-Receptor Encephalitis
title_fullStr Chronic Neuropsychological Sequelae in a Patient with Nontumorous Anti-NMDA-Receptor Encephalitis
title_full_unstemmed Chronic Neuropsychological Sequelae in a Patient with Nontumorous Anti-NMDA-Receptor Encephalitis
title_short Chronic Neuropsychological Sequelae in a Patient with Nontumorous Anti-NMDA-Receptor Encephalitis
title_sort chronic neuropsychological sequelae in a patient with nontumorous anti nmda receptor encephalitis
url http://dx.doi.org/10.1155/2017/5675732
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