Clinicopathological features and outcomes in patients with concurrent medullary and papillary thyroid carcinoma
ObjectiveThe co-existence of medullary thyroid carcinoma (MTC) and papillary thyroid carcinoma (PTC) is rare. The study analyzed the clinicopathological findings and prognosis of concomitant PTC in MTC patients.MethodsClinicopathological data and follow-up outcomes of 25 patients with concurrent med...
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1625989/full |
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| author | Ruonan Sun Ruonan Sun Xueting Liu Jiabin Liu Jiabin Liu Zhihui Li Zhihui Li Yichao Wang Yichao Wang |
| author_facet | Ruonan Sun Ruonan Sun Xueting Liu Jiabin Liu Jiabin Liu Zhihui Li Zhihui Li Yichao Wang Yichao Wang |
| author_sort | Ruonan Sun |
| collection | DOAJ |
| description | ObjectiveThe co-existence of medullary thyroid carcinoma (MTC) and papillary thyroid carcinoma (PTC) is rare. The study analyzed the clinicopathological findings and prognosis of concomitant PTC in MTC patients.MethodsClinicopathological data and follow-up outcomes of 25 patients with concurrent medullary and papillary thyroid carcinoma (combination group) between January 2009 and May 2024 were collected and analyzed retrospectively. We compared clinicopathologic characteristics and follow-up outcomes between patients with concurrent MTC and PTC (combination group) and those with MTC alone (MTC group).ResultsThe 25 patients with concurrent MTC and PTC comprised 19 females and 6 males. There were no statistically significant differences between the combination group and the MTC group in terms of age, gender, or pathological features such as the diameter of MTC lesions, multifocality, extra-thyroidal extension (ETE), number of lymph node (LN) resected, the number of LN metastasis, the maximum diameter of LN metastasis, and TNM staging. The recurrence rate was similar between the two groups. Univariate analysis showed that the max tumor diameter, capsule invasion, extracapsular invasion and recurrent nerve invasion were associated with the risk of biochemical/structural abnormalities in MTC group. Multivariate analysis showed that only the max tumor diameter and capsule invasion were significant independent prognostic factors for biochemical/structural abnormalities.ConclusionThe result of this comparative study between patients with MTC and PTC co-existence and those with MTC alone showed similar invasiveness and prognosis. |
| format | Article |
| id | doaj-art-ddd08eeeb0b04e18aa0080223cb001f8 |
| institution | DOAJ |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Endocrinology |
| spelling | doaj-art-ddd08eeeb0b04e18aa0080223cb001f82025-08-20T02:58:11ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-08-011610.3389/fendo.2025.16259891625989Clinicopathological features and outcomes in patients with concurrent medullary and papillary thyroid carcinomaRuonan Sun0Ruonan Sun1Xueting Liu2Jiabin Liu3Jiabin Liu4Zhihui Li5Zhihui Li6Yichao Wang7Yichao Wang8Division of Thyroid Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaWest China School of Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Evidence-Based Medicine and Clinical Epidemiology, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDivision of Thyroid Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDepartment of General Surgery, Shangjin Nanfu Hospital, Chengdu, Sichuan, ChinaDivision of Thyroid Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaLaboratory of Thyroid and Parathyroid Diseases, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDivision of Thyroid Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaLaboratory of Thyroid and Parathyroid Diseases, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaObjectiveThe co-existence of medullary thyroid carcinoma (MTC) and papillary thyroid carcinoma (PTC) is rare. The study analyzed the clinicopathological findings and prognosis of concomitant PTC in MTC patients.MethodsClinicopathological data and follow-up outcomes of 25 patients with concurrent medullary and papillary thyroid carcinoma (combination group) between January 2009 and May 2024 were collected and analyzed retrospectively. We compared clinicopathologic characteristics and follow-up outcomes between patients with concurrent MTC and PTC (combination group) and those with MTC alone (MTC group).ResultsThe 25 patients with concurrent MTC and PTC comprised 19 females and 6 males. There were no statistically significant differences between the combination group and the MTC group in terms of age, gender, or pathological features such as the diameter of MTC lesions, multifocality, extra-thyroidal extension (ETE), number of lymph node (LN) resected, the number of LN metastasis, the maximum diameter of LN metastasis, and TNM staging. The recurrence rate was similar between the two groups. Univariate analysis showed that the max tumor diameter, capsule invasion, extracapsular invasion and recurrent nerve invasion were associated with the risk of biochemical/structural abnormalities in MTC group. Multivariate analysis showed that only the max tumor diameter and capsule invasion were significant independent prognostic factors for biochemical/structural abnormalities.ConclusionThe result of this comparative study between patients with MTC and PTC co-existence and those with MTC alone showed similar invasiveness and prognosis.https://www.frontiersin.org/articles/10.3389/fendo.2025.1625989/fullmedullary thyroid carcinomapapillary thyroid carcinomaconcurrentprognosisthyroid cancer |
| spellingShingle | Ruonan Sun Ruonan Sun Xueting Liu Jiabin Liu Jiabin Liu Zhihui Li Zhihui Li Yichao Wang Yichao Wang Clinicopathological features and outcomes in patients with concurrent medullary and papillary thyroid carcinoma Frontiers in Endocrinology medullary thyroid carcinoma papillary thyroid carcinoma concurrent prognosis thyroid cancer |
| title | Clinicopathological features and outcomes in patients with concurrent medullary and papillary thyroid carcinoma |
| title_full | Clinicopathological features and outcomes in patients with concurrent medullary and papillary thyroid carcinoma |
| title_fullStr | Clinicopathological features and outcomes in patients with concurrent medullary and papillary thyroid carcinoma |
| title_full_unstemmed | Clinicopathological features and outcomes in patients with concurrent medullary and papillary thyroid carcinoma |
| title_short | Clinicopathological features and outcomes in patients with concurrent medullary and papillary thyroid carcinoma |
| title_sort | clinicopathological features and outcomes in patients with concurrent medullary and papillary thyroid carcinoma |
| topic | medullary thyroid carcinoma papillary thyroid carcinoma concurrent prognosis thyroid cancer |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1625989/full |
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