Prevention and Treatment of Intestinal Failure Syndrome in Children with Acute Necrotic Pancreatitis
AIM OF STUDY To evaluate the effectiveness of intestinal lavage with glucose-saline solution for acute necrotic pancreatitis in children..MATERIAL AND METHODS A retrospective analysis of the diagnosis and treatment of 48 children aged 3 to 17 years with impaired propulsive function of the intestine...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Sklifosovsky Research Institute for Emergency Medicine, Public Healthcare Institution of Moscow Healthcare Department
2025-01-01
|
| Series: | Неотложная медицинская помощь |
| Subjects: | |
| Online Access: | https://www.jnmp.ru/jour/article/view/2014 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850029650053431296 |
|---|---|
| author | D. A. Pyhteev L. M. Elin Yu. N. Filyushkin M. O. Elina Yu. Yu. Sokolov |
| author_facet | D. A. Pyhteev L. M. Elin Yu. N. Filyushkin M. O. Elina Yu. Yu. Sokolov |
| author_sort | D. A. Pyhteev |
| collection | DOAJ |
| description | AIM OF STUDY To evaluate the effectiveness of intestinal lavage with glucose-saline solution for acute necrotic pancreatitis in children..MATERIAL AND METHODS A retrospective analysis of the diagnosis and treatment of 48 children aged 3 to 17 years with impaired propulsive function of the intestine against the background of acute necrotic pancreatitis of moderate and severe severity was carried out. Intestinal insufficiency syndrome was diagnosed in 39 cases. In the 1st group (n=13) in I A phase in addition to standard therapy, intestinal lavage was performed during the disease phase, in the 2nd group (n=35) the standard therapy for acute necrotic pancreatitis was performed.RESULTS Median the duration of gastrostasis in group 1 was 4 days (IQR, interquartile range: 2; 5), in group 2-6 days (IQR: 4; 7) (from 2 to 13), p=0.0181. The duration of intestinal paresis in group 1 was 2 days (IQR: 2; 4), in group 2–4 days (IQR: 3; 5), p<0.0053. The median time of onset of independent stool in group 1 was 3 days (IQR: 3; 5), in group 2 — 5.5 days (IQR: 4.3; 6), p<0.0014. Reduction in the level of C-reactive protein by day 3–4: in group 1, the median was 8.2 mg/l (IQR: 1.16; 34.6) (from 0 to 46.9), in group 2 — 31.97 mg/l (IQR: 17.71; 112.4) (from 14 to 285), p=0.028. The risk of developing purulent complications was 4-fold higher in group 2, p=0.0088. The duration of hospitalization in the 1st group was shorter, p=0.0004.CONCLUSION Carrying out intestinal lavage in children with impaired propulsive function of the intestine against the background of acute necrotic pancreatitis significantly more quickly restores the function of the gastrointestinal tract and facilitates an earlier start of enteral feeding. |
| format | Article |
| id | doaj-art-ddcdcc45797b4ff3951cea6ce1222c56 |
| institution | DOAJ |
| issn | 2223-9022 2541-8017 |
| language | Russian |
| publishDate | 2025-01-01 |
| publisher | Sklifosovsky Research Institute for Emergency Medicine, Public Healthcare Institution of Moscow Healthcare Department |
| record_format | Article |
| series | Неотложная медицинская помощь |
| spelling | doaj-art-ddcdcc45797b4ff3951cea6ce1222c562025-08-20T02:59:28ZrusSklifosovsky Research Institute for Emergency Medicine, Public Healthcare Institution of Moscow Healthcare DepartmentНеотложная медицинская помощь2223-90222541-80172025-01-0113470671410.23934/2223-9022-2024-13-4-706-714993Prevention and Treatment of Intestinal Failure Syndrome in Children with Acute Necrotic PancreatitisD. A. Pyhteev0L. M. Elin1Yu. N. Filyushkin2M. O. Elina3Yu. Yu. Sokolov4M.F. Vladimirsky Moscow Regional Research Clinical InstituteM.F. Vladimirsky Moscow Regional Research Clinical InstituteM.F. Vladimirsky Moscow Regional Research Clinical InstituteM.F. Vladimirsky Moscow Regional Research Clinical InstituteRussian Medical Academy of Continuous Professional EducationAIM OF STUDY To evaluate the effectiveness of intestinal lavage with glucose-saline solution for acute necrotic pancreatitis in children..MATERIAL AND METHODS A retrospective analysis of the diagnosis and treatment of 48 children aged 3 to 17 years with impaired propulsive function of the intestine against the background of acute necrotic pancreatitis of moderate and severe severity was carried out. Intestinal insufficiency syndrome was diagnosed in 39 cases. In the 1st group (n=13) in I A phase in addition to standard therapy, intestinal lavage was performed during the disease phase, in the 2nd group (n=35) the standard therapy for acute necrotic pancreatitis was performed.RESULTS Median the duration of gastrostasis in group 1 was 4 days (IQR, interquartile range: 2; 5), in group 2-6 days (IQR: 4; 7) (from 2 to 13), p=0.0181. The duration of intestinal paresis in group 1 was 2 days (IQR: 2; 4), in group 2–4 days (IQR: 3; 5), p<0.0053. The median time of onset of independent stool in group 1 was 3 days (IQR: 3; 5), in group 2 — 5.5 days (IQR: 4.3; 6), p<0.0014. Reduction in the level of C-reactive protein by day 3–4: in group 1, the median was 8.2 mg/l (IQR: 1.16; 34.6) (from 0 to 46.9), in group 2 — 31.97 mg/l (IQR: 17.71; 112.4) (from 14 to 285), p=0.028. The risk of developing purulent complications was 4-fold higher in group 2, p=0.0088. The duration of hospitalization in the 1st group was shorter, p=0.0004.CONCLUSION Carrying out intestinal lavage in children with impaired propulsive function of the intestine against the background of acute necrotic pancreatitis significantly more quickly restores the function of the gastrointestinal tract and facilitates an earlier start of enteral feeding.https://www.jnmp.ru/jour/article/view/2014childrenacute pancreatitisacute necrotic pancreatitisparapancreatitisintestinal insufficiency syndromedynamic intestinal obstructionintestinal lavage |
| spellingShingle | D. A. Pyhteev L. M. Elin Yu. N. Filyushkin M. O. Elina Yu. Yu. Sokolov Prevention and Treatment of Intestinal Failure Syndrome in Children with Acute Necrotic Pancreatitis Неотложная медицинская помощь children acute pancreatitis acute necrotic pancreatitis parapancreatitis intestinal insufficiency syndrome dynamic intestinal obstruction intestinal lavage |
| title | Prevention and Treatment of Intestinal Failure Syndrome in Children with Acute Necrotic Pancreatitis |
| title_full | Prevention and Treatment of Intestinal Failure Syndrome in Children with Acute Necrotic Pancreatitis |
| title_fullStr | Prevention and Treatment of Intestinal Failure Syndrome in Children with Acute Necrotic Pancreatitis |
| title_full_unstemmed | Prevention and Treatment of Intestinal Failure Syndrome in Children with Acute Necrotic Pancreatitis |
| title_short | Prevention and Treatment of Intestinal Failure Syndrome in Children with Acute Necrotic Pancreatitis |
| title_sort | prevention and treatment of intestinal failure syndrome in children with acute necrotic pancreatitis |
| topic | children acute pancreatitis acute necrotic pancreatitis parapancreatitis intestinal insufficiency syndrome dynamic intestinal obstruction intestinal lavage |
| url | https://www.jnmp.ru/jour/article/view/2014 |
| work_keys_str_mv | AT dapyhteev preventionandtreatmentofintestinalfailuresyndromeinchildrenwithacutenecroticpancreatitis AT lmelin preventionandtreatmentofintestinalfailuresyndromeinchildrenwithacutenecroticpancreatitis AT yunfilyushkin preventionandtreatmentofintestinalfailuresyndromeinchildrenwithacutenecroticpancreatitis AT moelina preventionandtreatmentofintestinalfailuresyndromeinchildrenwithacutenecroticpancreatitis AT yuyusokolov preventionandtreatmentofintestinalfailuresyndromeinchildrenwithacutenecroticpancreatitis |