The Effect of Vitamin D3 Supplementation on Interleukin-6 and PRESS Score in Children with Pneumonia and Vitamin D Deficiency
Introduction: Pneumonia is a significant health issue in children under 5 years old. Vitamin D may help to reduce childhood mortality, morbidity, and interleukin-6 (IL-6) levels in children with pneumonia, but the evidence is still limited and controversial. This study aimed to evaluate the effect o...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Universitas Airlangga
2025-05-01
|
| Series: | Jurnal Respirasi |
| Subjects: | |
| Online Access: | https://e-journal.unair.ac.id/JR/article/view/65665 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Introduction: Pneumonia is a significant health issue in children under 5 years old. Vitamin D may help to reduce childhood mortality, morbidity, and interleukin-6 (IL-6) levels in children with pneumonia, but the evidence is still limited and controversial. This study aimed to evaluate the effect of vitamin D3 supplementation on IL-6 levels and clinical manifestations in children with pneumonia and vitamin D inadequacy.
Methods: This was a randomized, placebo-controlled, and double-blinded trial study. Twenty-eight children diagnosed with pneumonia and vitamin D deficiency were enrolled and divided into a supplementation (n=15) or placebo group (n=13). Children were given a single dose (100,000 international units/IU) of vitamin D3 or placebo on the first day of hospitalization. Clinical manifestations were assessed by the Pediatric Respiratory Severity Score (PRESS).
Results: The level of 25-hydroxyvitamin D (25-OH D3), IL-6, and PRESS score at baseline showed no significant difference between groups. Seven days post-supplementation, only the PRESS score showed a significant difference between groups (p=0.025). Analysis of the vitamin D3 group showed a significantly increased 25-OH D3 level and a reduced PRESS score (p=0.039 and p=0.02, respectively).
Conclusion: A single high dose of vitamin D3 supplementation in children with pneumonia and inadequate vitamin D levels helps elevate 25-OH D3 levels and reduce clinical manifestations, as indicated by the PRESS score. |
|---|---|
| ISSN: | 2407-0831 2621-8372 |