Investigation of Antiproliferative Effects of Home-Made and Commercial Apple Vinegars on Myeloma Cells
Vinegar is an aqueous food product made by a succession of yeast and acetic acid bacteria activities from fruits that contain high carbohydrates such as apples and grapes. Vinegar has been used as a dietary spice and natural remedy since ancient times due to its therapeutic properties including anti...
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| Format: | Article |
| Language: | English |
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Hasan Eleroğlu
2021-12-01
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| Series: | Turkish Journal of Agriculture: Food Science and Technology |
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| Online Access: | http://www.agrifoodscience.com/index.php/TURJAF/article/view/4416 |
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| author | Muhammet Mükerrem Kaya Soner Tutun Melike Sultan Usluer Hidayet Tutun |
| author_facet | Muhammet Mükerrem Kaya Soner Tutun Melike Sultan Usluer Hidayet Tutun |
| author_sort | Muhammet Mükerrem Kaya |
| collection | DOAJ |
| description | Vinegar is an aqueous food product made by a succession of yeast and acetic acid bacteria activities from fruits that contain high carbohydrates such as apples and grapes. Vinegar has been used as a dietary spice and natural remedy since ancient times due to its therapeutic properties including antimicrobial, antidiabetic, and anticancer activities. It has been shown that some bioactive compounds exhibiting antioxidant activity in vinegars lead to anticancer activity. The aim of the present study was to investigate antiproliferative effect of commercial and home-made apple vinegars in native and neutralized form on myeloma cells. In order to neutralize the vinegars, sodium hydroxide (NaOH) was used. A serial two-fold dilutions of the vinegars (50%, 25%, 12.5%, 6.25%, 3.12%, 1.56%, 0.78%, 0.39%) prepared with cell medium were treated to the cells. The MTT (3-(4.5-Dimethylthiazol-2-yl)-2.5-Diphenyltetrazolium Bromide) assay was used to determine the cellular viability in the cells treated with the vinegars. In this study, while commercial vinegar possessed a stronger antiproliferative activity than home-made vinegar, all native vinegars possessed stronger antiproliferative effect than neutralized vinegars. Interestingly, when home-made vinegar (both native and neutralized) concentrations were from 6.25 to 1.56%, the cell viability increased. Apple vinegar exhibited antiproliferative activity on myeloma cells; however, further studies are required to clarify the mechanisms underlying this activity. |
| format | Article |
| id | doaj-art-ddc7f35d66354e2cb33fa421e4c6c1f1 |
| institution | Kabale University |
| issn | 2148-127X |
| language | English |
| publishDate | 2021-12-01 |
| publisher | Hasan Eleroğlu |
| record_format | Article |
| series | Turkish Journal of Agriculture: Food Science and Technology |
| spelling | doaj-art-ddc7f35d66354e2cb33fa421e4c6c1f12025-08-20T03:25:06ZengHasan EleroğluTurkish Journal of Agriculture: Food Science and Technology2148-127X2021-12-019122173217810.24925/turjaf.v9i12.2173-2178.44162271Investigation of Antiproliferative Effects of Home-Made and Commercial Apple Vinegars on Myeloma CellsMuhammet Mükerrem Kaya0Soner Tutun1Melike Sultan Usluer2Hidayet Tutun3Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Burdur Mehmet Akif Ersoy University, BurdurDepartment of Food Hygiene and Technology, Faculty of Veterinary Medicine, Burdur Mehmet Akif Ersoy University, BurdurDepartment of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Burdur Mehmet Akif Ersoy University, BurdurDepartment of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Burdur Mehmet Akif Ersoy University, BurdurVinegar is an aqueous food product made by a succession of yeast and acetic acid bacteria activities from fruits that contain high carbohydrates such as apples and grapes. Vinegar has been used as a dietary spice and natural remedy since ancient times due to its therapeutic properties including antimicrobial, antidiabetic, and anticancer activities. It has been shown that some bioactive compounds exhibiting antioxidant activity in vinegars lead to anticancer activity. The aim of the present study was to investigate antiproliferative effect of commercial and home-made apple vinegars in native and neutralized form on myeloma cells. In order to neutralize the vinegars, sodium hydroxide (NaOH) was used. A serial two-fold dilutions of the vinegars (50%, 25%, 12.5%, 6.25%, 3.12%, 1.56%, 0.78%, 0.39%) prepared with cell medium were treated to the cells. The MTT (3-(4.5-Dimethylthiazol-2-yl)-2.5-Diphenyltetrazolium Bromide) assay was used to determine the cellular viability in the cells treated with the vinegars. In this study, while commercial vinegar possessed a stronger antiproliferative activity than home-made vinegar, all native vinegars possessed stronger antiproliferative effect than neutralized vinegars. Interestingly, when home-made vinegar (both native and neutralized) concentrations were from 6.25 to 1.56%, the cell viability increased. Apple vinegar exhibited antiproliferative activity on myeloma cells; however, further studies are required to clarify the mechanisms underlying this activity.http://www.agrifoodscience.com/index.php/TURJAF/article/view/4416antiproliferative activityapplemyelomavinegar |
| spellingShingle | Muhammet Mükerrem Kaya Soner Tutun Melike Sultan Usluer Hidayet Tutun Investigation of Antiproliferative Effects of Home-Made and Commercial Apple Vinegars on Myeloma Cells Turkish Journal of Agriculture: Food Science and Technology antiproliferative activity apple myeloma vinegar |
| title | Investigation of Antiproliferative Effects of Home-Made and Commercial Apple Vinegars on Myeloma Cells |
| title_full | Investigation of Antiproliferative Effects of Home-Made and Commercial Apple Vinegars on Myeloma Cells |
| title_fullStr | Investigation of Antiproliferative Effects of Home-Made and Commercial Apple Vinegars on Myeloma Cells |
| title_full_unstemmed | Investigation of Antiproliferative Effects of Home-Made and Commercial Apple Vinegars on Myeloma Cells |
| title_short | Investigation of Antiproliferative Effects of Home-Made and Commercial Apple Vinegars on Myeloma Cells |
| title_sort | investigation of antiproliferative effects of home made and commercial apple vinegars on myeloma cells |
| topic | antiproliferative activity apple myeloma vinegar |
| url | http://www.agrifoodscience.com/index.php/TURJAF/article/view/4416 |
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