Examine the pharmacokinetics of three formulations of the drug for regenerative gene therapy damage the surface of human tissues of various etiologies
The purpose of this study was to compare the pharmacokinetic and pharmacodynamic parameters of three formulations of a new drug on the basis of plasmid DNA pCIGF for regenerative gene therapy damage the surface of human tissues of various etiologies. Preclinical study of the pharmacological properti...
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| Format: | Article |
| Language: | Russian |
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LLC “Publisher OKI”
2013-04-01
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| Series: | Фармакокинетика и Фармакодинамика |
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| Online Access: | https://www.pharmacokinetica.ru/jour/article/view/128 |
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| author | I. V. Duhovlinov R. I. Al-Shekhadat A. I. Orlov |
| author_facet | I. V. Duhovlinov R. I. Al-Shekhadat A. I. Orlov |
| author_sort | I. V. Duhovlinov |
| collection | DOAJ |
| description | The purpose of this study was to compare the pharmacokinetic and pharmacodynamic parameters of three formulations of a new drug on the basis of plasmid DNA pCIGF for regenerative gene therapy damage the surface of human tissues of various etiologies. Preclinical study of the pharmacological properties of the drug and drug safety carried out in mice, which was administered once and twice. Introduction of liquid and lyophilized forms of the drug was carried out by intramuscular injection, topically applied gel form. Analyzed various organs: brain, heart, blood, lung, liver, kidney, spleen, muscle for the presence of plasmid depending on the time after administration. |
| format | Article |
| id | doaj-art-ddc44d85b03f43acb2a2231e455588e9 |
| institution | Kabale University |
| issn | 2587-7836 2686-8830 |
| language | Russian |
| publishDate | 2013-04-01 |
| publisher | LLC “Publisher OKI” |
| record_format | Article |
| series | Фармакокинетика и Фармакодинамика |
| spelling | doaj-art-ddc44d85b03f43acb2a2231e455588e92025-08-20T03:57:48ZrusLLC “Publisher OKI”Фармакокинетика и Фармакодинамика2587-78362686-88302013-04-01013539127Examine the pharmacokinetics of three formulations of the drug for regenerative gene therapy damage the surface of human tissues of various etiologiesI. V. Duhovlinov0R. I. Al-Shekhadat1A. I. Orlov2LLC «Pharma Gen»LLC «Pharma Gen»FGBI «Scientific Research Institute of Experimental Medicine» RAMS, St. PetersburgThe purpose of this study was to compare the pharmacokinetic and pharmacodynamic parameters of three formulations of a new drug on the basis of plasmid DNA pCIGF for regenerative gene therapy damage the surface of human tissues of various etiologies. Preclinical study of the pharmacological properties of the drug and drug safety carried out in mice, which was administered once and twice. Introduction of liquid and lyophilized forms of the drug was carried out by intramuscular injection, topically applied gel form. Analyzed various organs: brain, heart, blood, lung, liver, kidney, spleen, muscle for the presence of plasmid depending on the time after administration.https://www.pharmacokinetica.ru/jour/article/view/128фармакокинетикафармакодинамикарегенеративная генная терапияpharmacokineticspharmacodynamicsregenerative gene therapy |
| spellingShingle | I. V. Duhovlinov R. I. Al-Shekhadat A. I. Orlov Examine the pharmacokinetics of three formulations of the drug for regenerative gene therapy damage the surface of human tissues of various etiologies Фармакокинетика и Фармакодинамика фармакокинетика фармакодинамика регенеративная генная терапия pharmacokinetics pharmacodynamics regenerative gene therapy |
| title | Examine the pharmacokinetics of three formulations of the drug for regenerative gene therapy damage the surface of human tissues of various etiologies |
| title_full | Examine the pharmacokinetics of three formulations of the drug for regenerative gene therapy damage the surface of human tissues of various etiologies |
| title_fullStr | Examine the pharmacokinetics of three formulations of the drug for regenerative gene therapy damage the surface of human tissues of various etiologies |
| title_full_unstemmed | Examine the pharmacokinetics of three formulations of the drug for regenerative gene therapy damage the surface of human tissues of various etiologies |
| title_short | Examine the pharmacokinetics of three formulations of the drug for regenerative gene therapy damage the surface of human tissues of various etiologies |
| title_sort | examine the pharmacokinetics of three formulations of the drug for regenerative gene therapy damage the surface of human tissues of various etiologies |
| topic | фармакокинетика фармакодинамика регенеративная генная терапия pharmacokinetics pharmacodynamics regenerative gene therapy |
| url | https://www.pharmacokinetica.ru/jour/article/view/128 |
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