Aconitine promotes ROS-activated P38/MAPK/Nrf2 pathway to inhibit autophagy and promote myocardial injury

Aconitine promotes ROS-activated P38/MAPK/Nrf2 pathway to inhibit autophagy and promote myocardial injury

Abstract Background Aconitine has cardiotoxicity, but the mechanism of cardiotoxicity induced by aconitine is limited. The aim of this study was to investigate the mechanism of myocardial injury induced by aconitine. Methods Using aconitine, ROS inhibitor N-acetylcysteine(NAC), the autophagy activit...

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Bibliographic Details
Main Authors: Chunai Yang, Jinxiao Fu, Fenshuang Zheng, Yangshan Fu, Xueqiong Duan, Ruiling Zuo, Junbo Zhu
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Journal of Cardiothoracic Surgery
Subjects:
Aconitine
ROS
Autophagy
P38/MAPK/Nrf2 pathway
Myocardial injury
Online Access:https://doi.org/10.1186/s13019-024-03149-0
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