Resiquimod induces a mixed Th1 and Th2 response via STAT1 and STAT3 signalling in chickens

Resiquimod induces a mixed Th1 and Th2 response via STAT1 and STAT3 signalling in chickens

Resiquimod (R-848), a synthetic TLR7 agonist, modulates immune responses, primarily inducing Th1-biased immunity in mammals. In contrast, our previous studies revealed that R-848 stimulates both Th1 and Th2 responses in chickens. The current research investigates the molecular mechanisms underlying...

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Bibliographic Details
Main Authors: Deepthi Kappala, Saravanan Ramakrishnan, Patel Nikunjkumar Prakashbhai, Abinaya Kaliappan, Prasad Thomas, Jörg Linde, Mithilesh Singh, Sohini Dey, Madhan Mohan Chellappa
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Biochemistry and Biophysics Reports
Subjects:
Resiquimod
Toll-like receptor signalling
Chicken
Th1 and Th2 immune responses
Transcriptomic profile
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580825000287
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