A deep learning based ultrasound diagnostic tool driven by 3D visualization of thyroid nodules

Abstract Recognizing the limitations of computer-assisted tools for thyroid nodule diagnosis using static ultrasound images, this study developed a diagnostic tool utilizing dynamic ultrasound video, namely Thyroid Nodules Visualization (TNVis), by leveraging a two-stage deep learning framework that...

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Main Authors: Yahan Zhou, Chen Chen, Jincao Yao, Jiabin Yu, Bojian Feng, Lin Sui, Yuqi Yan, Xiayi Chen, Yuanzhen Liu, Xiao Zhang, Hui Wang, Qianmeng Pan, Weijie Zou, Qi Zhang, Lu Lin, Chenke Xu, Shengxing Yuan, Qingquan He, Xiaofan Ding, Ping Liang, Vicky Yang Wang, Dong Xu
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:npj Digital Medicine
Online Access:https://doi.org/10.1038/s41746-025-01455-y
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author Yahan Zhou
Chen Chen
Jincao Yao
Jiabin Yu
Bojian Feng
Lin Sui
Yuqi Yan
Xiayi Chen
Yuanzhen Liu
Xiao Zhang
Hui Wang
Qianmeng Pan
Weijie Zou
Qi Zhang
Lu Lin
Chenke Xu
Shengxing Yuan
Qingquan He
Xiaofan Ding
Ping Liang
Vicky Yang Wang
Dong Xu
author_facet Yahan Zhou
Chen Chen
Jincao Yao
Jiabin Yu
Bojian Feng
Lin Sui
Yuqi Yan
Xiayi Chen
Yuanzhen Liu
Xiao Zhang
Hui Wang
Qianmeng Pan
Weijie Zou
Qi Zhang
Lu Lin
Chenke Xu
Shengxing Yuan
Qingquan He
Xiaofan Ding
Ping Liang
Vicky Yang Wang
Dong Xu
author_sort Yahan Zhou
collection DOAJ
description Abstract Recognizing the limitations of computer-assisted tools for thyroid nodule diagnosis using static ultrasound images, this study developed a diagnostic tool utilizing dynamic ultrasound video, namely Thyroid Nodules Visualization (TNVis), by leveraging a two-stage deep learning framework that involved three-dimensional (3D) visualization. In this multicenter study, 4569 cases were included for framework development, and data from seven hospitals were employed for diagnostic validation. TNVis achieved a Dice similarity coefficient of 0.90 after internal testing. For the external validation, TNVis significantly improved radiologists’ performance, reaching an AUC of 0.79, compared to their diagnostic performance without the use of TNVis (AUC: 0.66; p < 0.001) and those with partial assistance (AUC: 0.72; p < 0.001). In conclusion, the TNVis-assisted diagnostic strategy not only significantly improves the diagnostic ability of radiologists but also closely imitates their clinical diagnostic procedures and provides them with an objective 3D representation of the nodules for precise and personalized diagnosis and treatment planning.
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publisher Nature Portfolio
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spelling doaj-art-ddbe86d60ca74d7fb68f721805e8fdcd2025-08-20T02:59:37ZengNature Portfolionpj Digital Medicine2398-63522025-02-018111110.1038/s41746-025-01455-yA deep learning based ultrasound diagnostic tool driven by 3D visualization of thyroid nodulesYahan Zhou0Chen Chen1Jincao Yao2Jiabin Yu3Bojian Feng4Lin Sui5Yuqi Yan6Xiayi Chen7Yuanzhen Liu8Xiao Zhang9Hui Wang10Qianmeng Pan11Weijie Zou12Qi Zhang13Lu Lin14Chenke Xu15Shengxing Yuan16Qingquan He17Xiaofan Ding18Ping Liang19Vicky Yang Wang20Dong Xu21Center of Intelligent Diagnosis and Therapy (Taizhou), Hangzhou Institute of Medicine (HIM), Chinese Academy of SciencesDepartment of Biomedical Sciences, Faculty of Health Sciences, University of MacauDepartment of Diagnostic Ultrasound Imaging & Interventional Therapy, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of SciencesCollege of Information Engineering, China Jiliang UniversityCenter of Intelligent Diagnosis and Therapy (Taizhou), Hangzhou Institute of Medicine (HIM), Chinese Academy of SciencesCenter of Intelligent Diagnosis and Therapy (Taizhou), Hangzhou Institute of Medicine (HIM), Chinese Academy of SciencesCenter of Intelligent Diagnosis and Therapy (Taizhou), Hangzhou Institute of Medicine (HIM), Chinese Academy of SciencesCenter of Intelligent Diagnosis and Therapy (Taizhou), Hangzhou Institute of Medicine (HIM), Chinese Academy of SciencesCenter of Intelligent Diagnosis and Therapy (Taizhou), Hangzhou Institute of Medicine (HIM), Chinese Academy of SciencesThe First People’s Hospital of Hangzhou Lin’an DistrictDepartment of Ultrasound, Taizhou Campus of Zhejiang Cancer Hospital (Taizhou Cancer Hospital)Department of Ultrasound, Taizhou Campus of Zhejiang Cancer Hospital (Taizhou Cancer Hospital)Department of Diagnostic Ultrasound Imaging & Interventional Therapy, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of SciencesShaoxing People’s HospitalZhoushan Hospital of Traditional Chinese MedicineAffiliated Hangzhou First People’s Hospital, School of Medicine, Westlake UniversityDepartment of Ultrasonography, Qujing No.1 Hospital, Affiliated Hospital of Kunming Medical UniversityTaizhou Key Laboratory of Minimally Invasive Interventional Therapy & Artificial Intelligence, Taizhou Campus of Zhejiang Cancer Hospital (Taizhou Cancer Hospital)Department of Biomedical Sciences, Faculty of Health Sciences, University of MacauDepartment of Ultrasound, Chinese PLA General Hospital, Chinese PLA Medical SchoolCenter of Intelligent Diagnosis and Therapy (Taizhou), Hangzhou Institute of Medicine (HIM), Chinese Academy of SciencesCenter of Intelligent Diagnosis and Therapy (Taizhou), Hangzhou Institute of Medicine (HIM), Chinese Academy of SciencesAbstract Recognizing the limitations of computer-assisted tools for thyroid nodule diagnosis using static ultrasound images, this study developed a diagnostic tool utilizing dynamic ultrasound video, namely Thyroid Nodules Visualization (TNVis), by leveraging a two-stage deep learning framework that involved three-dimensional (3D) visualization. In this multicenter study, 4569 cases were included for framework development, and data from seven hospitals were employed for diagnostic validation. TNVis achieved a Dice similarity coefficient of 0.90 after internal testing. For the external validation, TNVis significantly improved radiologists’ performance, reaching an AUC of 0.79, compared to their diagnostic performance without the use of TNVis (AUC: 0.66; p < 0.001) and those with partial assistance (AUC: 0.72; p < 0.001). In conclusion, the TNVis-assisted diagnostic strategy not only significantly improves the diagnostic ability of radiologists but also closely imitates their clinical diagnostic procedures and provides them with an objective 3D representation of the nodules for precise and personalized diagnosis and treatment planning.https://doi.org/10.1038/s41746-025-01455-y
spellingShingle Yahan Zhou
Chen Chen
Jincao Yao
Jiabin Yu
Bojian Feng
Lin Sui
Yuqi Yan
Xiayi Chen
Yuanzhen Liu
Xiao Zhang
Hui Wang
Qianmeng Pan
Weijie Zou
Qi Zhang
Lu Lin
Chenke Xu
Shengxing Yuan
Qingquan He
Xiaofan Ding
Ping Liang
Vicky Yang Wang
Dong Xu
A deep learning based ultrasound diagnostic tool driven by 3D visualization of thyroid nodules
npj Digital Medicine
title A deep learning based ultrasound diagnostic tool driven by 3D visualization of thyroid nodules
title_full A deep learning based ultrasound diagnostic tool driven by 3D visualization of thyroid nodules
title_fullStr A deep learning based ultrasound diagnostic tool driven by 3D visualization of thyroid nodules
title_full_unstemmed A deep learning based ultrasound diagnostic tool driven by 3D visualization of thyroid nodules
title_short A deep learning based ultrasound diagnostic tool driven by 3D visualization of thyroid nodules
title_sort deep learning based ultrasound diagnostic tool driven by 3d visualization of thyroid nodules
url https://doi.org/10.1038/s41746-025-01455-y
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