Dimensions of Gut Dysfunction in Irritable Bowel Syndrome: Altered Sensory Function
Growing evidence suggests that symptoms in patients with irritable bowel syndrome (IBS) may be due to a visceral sensory dysfunction. Specifically, it has been shown that patients with IBS have hypersensitive responses to distension of the rectum, whereas their tolerance to somatic stimuli is normal...
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| Format: | Article |
| Language: | English |
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Wiley
1999-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/1999/963469 |
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| author | Fernando Azpiroz |
| author_facet | Fernando Azpiroz |
| author_sort | Fernando Azpiroz |
| collection | DOAJ |
| description | Growing evidence suggests that
symptoms in patients with irritable bowel syndrome (IBS) may be
due to a visceral sensory dysfunction. Specifically, it has been
shown that patients with IBS have hypersensitive responses to distension
of the rectum, whereas their tolerance to somatic stimuli is
normal or even increased. Furthermore, patients with IBS have
hypersensitivity of the small bowel, which selectively affects
mechanosensitive afferents, with normal perception of electrical
stimulation of the gut. Sensory dysfunctions may also be associated
with altered reflex activity, which may contribute to the clinical
symptoms. Normally, a series of mechanisms at different strata
of the nervous system modulate visceral afferent input and determine
conscious perception. Conceivably, a dysfunction of these
regulatory mechanisms may alter sensitivity in clinical conditions.
To date, neither the origin nor the clinical significance of
visceral hyperalgesia has been elucidated. However, it seems likely
that the sensory and reflex dysfunctions of the gut in IBS may
combine to different degrees, and their interaction may explain
the clinical pleomorphism of the syndrome. |
| format | Article |
| id | doaj-art-ddb4ae3516734388bd42b8ecd3febbde |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 1999-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-ddb4ae3516734388bd42b8ecd3febbde2025-08-20T03:26:21ZengWileyCanadian Journal of Gastroenterology0835-79001999-01-0113Suppl A12A14A10.1155/1999/963469Dimensions of Gut Dysfunction in Irritable Bowel Syndrome: Altered Sensory FunctionFernando Azpiroz0Digestive System Research Unit, Hospital General Vall d’Hebron, Autonomous University of Barcelona, Barcelona, SpainGrowing evidence suggests that symptoms in patients with irritable bowel syndrome (IBS) may be due to a visceral sensory dysfunction. Specifically, it has been shown that patients with IBS have hypersensitive responses to distension of the rectum, whereas their tolerance to somatic stimuli is normal or even increased. Furthermore, patients with IBS have hypersensitivity of the small bowel, which selectively affects mechanosensitive afferents, with normal perception of electrical stimulation of the gut. Sensory dysfunctions may also be associated with altered reflex activity, which may contribute to the clinical symptoms. Normally, a series of mechanisms at different strata of the nervous system modulate visceral afferent input and determine conscious perception. Conceivably, a dysfunction of these regulatory mechanisms may alter sensitivity in clinical conditions. To date, neither the origin nor the clinical significance of visceral hyperalgesia has been elucidated. However, it seems likely that the sensory and reflex dysfunctions of the gut in IBS may combine to different degrees, and their interaction may explain the clinical pleomorphism of the syndrome.http://dx.doi.org/10.1155/1999/963469 |
| spellingShingle | Fernando Azpiroz Dimensions of Gut Dysfunction in Irritable Bowel Syndrome: Altered Sensory Function Canadian Journal of Gastroenterology |
| title | Dimensions of Gut Dysfunction in Irritable Bowel Syndrome: Altered Sensory Function |
| title_full | Dimensions of Gut Dysfunction in Irritable Bowel Syndrome: Altered Sensory Function |
| title_fullStr | Dimensions of Gut Dysfunction in Irritable Bowel Syndrome: Altered Sensory Function |
| title_full_unstemmed | Dimensions of Gut Dysfunction in Irritable Bowel Syndrome: Altered Sensory Function |
| title_short | Dimensions of Gut Dysfunction in Irritable Bowel Syndrome: Altered Sensory Function |
| title_sort | dimensions of gut dysfunction in irritable bowel syndrome altered sensory function |
| url | http://dx.doi.org/10.1155/1999/963469 |
| work_keys_str_mv | AT fernandoazpiroz dimensionsofgutdysfunctioninirritablebowelsyndromealteredsensoryfunction |