Genetic Aspects of Non-Alcoholic Fatty Liver Disease
Non-alcoholic fatty liver disease (NAFLD) is the most commonly diagnosed hepatopathy. There is an increase in the incidence of NAFLD in the structure of liver diseases in children and adolescents, which is directly related to the increasing prevalence of obesity. The spectrum of liver tissue changes...
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| Format: | Article |
| Language: | English |
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"Paediatrician" Publishers LLC
2019-01-01
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| Series: | Вопросы современной педиатрии |
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| Online Access: | https://vsp.spr-journal.ru/jour/article/view/1975 |
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| author | Pavel O. Bogomolov Kseniya Yu. Kokina Aleksander Yu. Mayorov Ekaterina E. Mishina |
| author_facet | Pavel O. Bogomolov Kseniya Yu. Kokina Aleksander Yu. Mayorov Ekaterina E. Mishina |
| author_sort | Pavel O. Bogomolov |
| collection | DOAJ |
| description | Non-alcoholic fatty liver disease (NAFLD) is the most commonly diagnosed hepatopathy. There is an increase in the incidence of NAFLD in the structure of liver diseases in children and adolescents, which is directly related to the increasing prevalence of obesity. The spectrum of liver tissue changes in NAFLD ranges from benign hepatocellular steatosis to non-alcoholic steatohepatitis (NASH), fibrosis, cirrhosis of the liver, and hepatocellular carcinoma. With the increasing prevalence of NAFLD in children, we can expect an increase in the incidence of adverse outcomes among people of working age. The key problem for NAFLD is the prediction of disease outcomes. In epidemiological and genetic studies, the relationship between the morphological stage of NAFLD and hereditary factors is shown. Currently, there are three genes associated with NAFLD (PNPLA3, TM6SF2, and GCKR), which, together with the genes responsible for insulin resistance, lipid deposition, inflammation and fibrogenesis in hepatocytes, determine the phenotype of fatty liver disease. The article considers the modern understanding of the issues of genetics, development of liver steatosis and progression of NASH. It is expected that this knowledge can transform our risk stratification strategies in patients with NAFLD and help identify new therapeutic goals. |
| format | Article |
| id | doaj-art-ddb3d5f49ca94b46af367624ee18177e |
| institution | Kabale University |
| issn | 1682-5527 1682-5535 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | "Paediatrician" Publishers LLC |
| record_format | Article |
| series | Вопросы современной педиатрии |
| spelling | doaj-art-ddb3d5f49ca94b46af367624ee18177e2025-08-20T03:34:41Zeng"Paediatrician" Publishers LLCВопросы современной педиатрии1682-55271682-55352019-01-0117644244810.15690/vsp.v17i6.19741788Genetic Aspects of Non-Alcoholic Fatty Liver DiseasePavel O. Bogomolov0Kseniya Yu. Kokina1Aleksander Yu. Mayorov2Ekaterina E. Mishina3Vladimirsky Moscow Regional Research Clinical InstituteVladimirsky Moscow Regional Research Clinical InstituteNational Medical Research Centre of Endocrinology,National Medical Research Centre of Endocrinology,Non-alcoholic fatty liver disease (NAFLD) is the most commonly diagnosed hepatopathy. There is an increase in the incidence of NAFLD in the structure of liver diseases in children and adolescents, which is directly related to the increasing prevalence of obesity. The spectrum of liver tissue changes in NAFLD ranges from benign hepatocellular steatosis to non-alcoholic steatohepatitis (NASH), fibrosis, cirrhosis of the liver, and hepatocellular carcinoma. With the increasing prevalence of NAFLD in children, we can expect an increase in the incidence of adverse outcomes among people of working age. The key problem for NAFLD is the prediction of disease outcomes. In epidemiological and genetic studies, the relationship between the morphological stage of NAFLD and hereditary factors is shown. Currently, there are three genes associated with NAFLD (PNPLA3, TM6SF2, and GCKR), which, together with the genes responsible for insulin resistance, lipid deposition, inflammation and fibrogenesis in hepatocytes, determine the phenotype of fatty liver disease. The article considers the modern understanding of the issues of genetics, development of liver steatosis and progression of NASH. It is expected that this knowledge can transform our risk stratification strategies in patients with NAFLD and help identify new therapeutic goals.https://vsp.spr-journal.ru/jour/article/view/1975non-alcoholic fatty liver diseasenon-alcoholic steatohepatitisgenotypingpnpla3 genemboat7 genetm6sf2 genegckr gene |
| spellingShingle | Pavel O. Bogomolov Kseniya Yu. Kokina Aleksander Yu. Mayorov Ekaterina E. Mishina Genetic Aspects of Non-Alcoholic Fatty Liver Disease Вопросы современной педиатрии non-alcoholic fatty liver disease non-alcoholic steatohepatitis genotyping pnpla3 gene mboat7 gene tm6sf2 gene gckr gene |
| title | Genetic Aspects of Non-Alcoholic Fatty Liver Disease |
| title_full | Genetic Aspects of Non-Alcoholic Fatty Liver Disease |
| title_fullStr | Genetic Aspects of Non-Alcoholic Fatty Liver Disease |
| title_full_unstemmed | Genetic Aspects of Non-Alcoholic Fatty Liver Disease |
| title_short | Genetic Aspects of Non-Alcoholic Fatty Liver Disease |
| title_sort | genetic aspects of non alcoholic fatty liver disease |
| topic | non-alcoholic fatty liver disease non-alcoholic steatohepatitis genotyping pnpla3 gene mboat7 gene tm6sf2 gene gckr gene |
| url | https://vsp.spr-journal.ru/jour/article/view/1975 |
| work_keys_str_mv | AT pavelobogomolov geneticaspectsofnonalcoholicfattyliverdisease AT kseniyayukokina geneticaspectsofnonalcoholicfattyliverdisease AT aleksanderyumayorov geneticaspectsofnonalcoholicfattyliverdisease AT ekaterinaemishina geneticaspectsofnonalcoholicfattyliverdisease |