Sildenafil alters biogenic amines and increases oxidative damage in brain regions of insulin-hypoglycemic rats

Sildenafil alters biogenic amines and increases oxidative damage in brain regions of insulin-hypoglycemic rats

The aim of the present study was to determine the effect of sildenafil on dopamine, 5-hydroxyindol acetic acid (5-HIAA) and selected biomarkers of oxidative stress in the brain of hypoglycemic rats. The animals were treated intraperitoneally as follows: group 1 (control), saline solution; group 2, i...

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Main Authors: Guzmán David Calderón, Brizuela Norma Osnaya, Herrera Maribel Ortíz, Peraza Armando Valenzuela, Mejía Gerardo Barragán, Olguín Hugo Juárez, Jiménez Francisca Trujillo
Format: Article
Language:English
Published: Sciendo 2020-03-01
Series:Acta Pharmaceutica
Subjects:
sildenafil
rat
hypoglycemia
biogenic amines
glutathione
h2o2
lipid peroxidation
Online Access:https://doi.org/10.2478/acph-2020-0016
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