Association between lifestyle, multiple chronic conditions, mental health status and the severity of lower urinary tract symptoms/benign prostatic hyperplasia in Chinese elderly
Background and objectiveThe etiology and pathogenesis of lower urinary tract symptoms/benign prostatic hyperplasia (LUTS/BPH) are complex, and understanding of factors related to symptom severity can improve the disease prognosis. The aim of this study was to explore the association between LUTS/BPH...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-06-01
|
| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1545344/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849683059120537600 |
|---|---|
| author | Yifan Wu Yifan Wu Yuwei Zhang Yuwei Zhang Xinwei Liu Xinwei Liu Yongneng Huang Yongneng Huang Ye Hua Ninghan Feng Ninghan Feng |
| author_facet | Yifan Wu Yifan Wu Yuwei Zhang Yuwei Zhang Xinwei Liu Xinwei Liu Yongneng Huang Yongneng Huang Ye Hua Ninghan Feng Ninghan Feng |
| author_sort | Yifan Wu |
| collection | DOAJ |
| description | Background and objectiveThe etiology and pathogenesis of lower urinary tract symptoms/benign prostatic hyperplasia (LUTS/BPH) are complex, and understanding of factors related to symptom severity can improve the disease prognosis. The aim of this study was to explore the association between LUTS/BPH severity and lifestyle, multiple chronic conditions (MCC), and mental health status in Chinese elderly individuals, and to provide a reference for developing comprehensive intervention measures.MethodsA total of 806 patients aged 60 and above with LUTS/BPH were divided into mild and moderate-to-severe groups based on IPSS assessment. All participants completed data collection on general demographics, clinical characteristics, lifestyle factors, MCC, and mental health status (including anxiety, depression, and sleep quality). A binary logistic model was employed to investigate the influence of lifestyle, MCC, and mental health status on LUTS/BPH severity.ResultsThe moderate-to-severe group had significantly higher rates of unhealthy lifestyle habits, MCC, and mental health problems compared to the mild group. After adjusting for confounders (such as age, disease duration, prostate volume, total prostate-specific antigen, C-reactive protein, post-voided residual urine, urea nitrogen, etc.), current smoking (OR = 1.995, 95%CI:1.270–3.134), unhealthy dietary habits (OR = 1.590, 95%CI: 1.059–2.386), and lack of active exercise (OR = 1.996, 95%CI:1.274–3.127) were positively correlated with the severity of BPH/LUTS. Conversely, the absence of heart disease (OR = 0.435, 95%CI:0.268–0.707), normal lipid profile (OR = 0.587, 95%CI:0.354–0.973), no diabetes mellitus (OR = 0.523, 95%CI:0.312–0.878), no depressive disorder (OR = 0.447, 95%CI:0.204–0.979) and no sleep disorder (OR = 0.494, 95%CI:0.322–0.758) were significantly negatively correlated with the severity of BPH/LUTS.ConclusionThe study revealed a strong correlation between the severity of LUTS/BPH and poor lifestyle, multiple chronic diseases, and mental health problems. Therefore, the prevention and treatment of LUTS/BPH should fully consider these factors. |
| format | Article |
| id | doaj-art-ddb05da7597944a6846bbb3266301ce8 |
| institution | DOAJ |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-ddb05da7597944a6846bbb3266301ce82025-08-20T03:24:01ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-06-011210.3389/fmed.2025.15453441545344Association between lifestyle, multiple chronic conditions, mental health status and the severity of lower urinary tract symptoms/benign prostatic hyperplasia in Chinese elderlyYifan Wu0Yifan Wu1Yuwei Zhang2Yuwei Zhang3Xinwei Liu4Xinwei Liu5Yongneng Huang6Yongneng Huang7Ye Hua8Ninghan Feng9Ninghan Feng10Department of Urology, Jiangnan University Medical Center, Wuxi, ChinaWuxi School of Medicine, Jiangnan University, Wuxi, ChinaDepartment of Urology, Jiangnan University Medical Center, Wuxi, ChinaMedical School of Nantong University, Nantong, ChinaDepartment of Urology, Jiangnan University Medical Center, Wuxi, ChinaWuxi School of Medicine, Jiangnan University, Wuxi, ChinaDepartment of Urology, Jiangnan University Medical Center, Wuxi, ChinaWuxi School of Medicine, Jiangnan University, Wuxi, ChinaDepartment of Neurology, Jiangnan University Medical Center, Wuxi, ChinaDepartment of Urology, Jiangnan University Medical Center, Wuxi, ChinaWuxi School of Medicine, Jiangnan University, Wuxi, ChinaBackground and objectiveThe etiology and pathogenesis of lower urinary tract symptoms/benign prostatic hyperplasia (LUTS/BPH) are complex, and understanding of factors related to symptom severity can improve the disease prognosis. The aim of this study was to explore the association between LUTS/BPH severity and lifestyle, multiple chronic conditions (MCC), and mental health status in Chinese elderly individuals, and to provide a reference for developing comprehensive intervention measures.MethodsA total of 806 patients aged 60 and above with LUTS/BPH were divided into mild and moderate-to-severe groups based on IPSS assessment. All participants completed data collection on general demographics, clinical characteristics, lifestyle factors, MCC, and mental health status (including anxiety, depression, and sleep quality). A binary logistic model was employed to investigate the influence of lifestyle, MCC, and mental health status on LUTS/BPH severity.ResultsThe moderate-to-severe group had significantly higher rates of unhealthy lifestyle habits, MCC, and mental health problems compared to the mild group. After adjusting for confounders (such as age, disease duration, prostate volume, total prostate-specific antigen, C-reactive protein, post-voided residual urine, urea nitrogen, etc.), current smoking (OR = 1.995, 95%CI:1.270–3.134), unhealthy dietary habits (OR = 1.590, 95%CI: 1.059–2.386), and lack of active exercise (OR = 1.996, 95%CI:1.274–3.127) were positively correlated with the severity of BPH/LUTS. Conversely, the absence of heart disease (OR = 0.435, 95%CI:0.268–0.707), normal lipid profile (OR = 0.587, 95%CI:0.354–0.973), no diabetes mellitus (OR = 0.523, 95%CI:0.312–0.878), no depressive disorder (OR = 0.447, 95%CI:0.204–0.979) and no sleep disorder (OR = 0.494, 95%CI:0.322–0.758) were significantly negatively correlated with the severity of BPH/LUTS.ConclusionThe study revealed a strong correlation between the severity of LUTS/BPH and poor lifestyle, multiple chronic diseases, and mental health problems. Therefore, the prevention and treatment of LUTS/BPH should fully consider these factors.https://www.frontiersin.org/articles/10.3389/fmed.2025.1545344/fulllower urinary tract symptomsbenign prostatic hyperplasialifestylemultiple chronic conditionsmental healthgeriatric medicine |
| spellingShingle | Yifan Wu Yifan Wu Yuwei Zhang Yuwei Zhang Xinwei Liu Xinwei Liu Yongneng Huang Yongneng Huang Ye Hua Ninghan Feng Ninghan Feng Association between lifestyle, multiple chronic conditions, mental health status and the severity of lower urinary tract symptoms/benign prostatic hyperplasia in Chinese elderly Frontiers in Medicine lower urinary tract symptoms benign prostatic hyperplasia lifestyle multiple chronic conditions mental health geriatric medicine |
| title | Association between lifestyle, multiple chronic conditions, mental health status and the severity of lower urinary tract symptoms/benign prostatic hyperplasia in Chinese elderly |
| title_full | Association between lifestyle, multiple chronic conditions, mental health status and the severity of lower urinary tract symptoms/benign prostatic hyperplasia in Chinese elderly |
| title_fullStr | Association between lifestyle, multiple chronic conditions, mental health status and the severity of lower urinary tract symptoms/benign prostatic hyperplasia in Chinese elderly |
| title_full_unstemmed | Association between lifestyle, multiple chronic conditions, mental health status and the severity of lower urinary tract symptoms/benign prostatic hyperplasia in Chinese elderly |
| title_short | Association between lifestyle, multiple chronic conditions, mental health status and the severity of lower urinary tract symptoms/benign prostatic hyperplasia in Chinese elderly |
| title_sort | association between lifestyle multiple chronic conditions mental health status and the severity of lower urinary tract symptoms benign prostatic hyperplasia in chinese elderly |
| topic | lower urinary tract symptoms benign prostatic hyperplasia lifestyle multiple chronic conditions mental health geriatric medicine |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1545344/full |
| work_keys_str_mv | AT yifanwu associationbetweenlifestylemultiplechronicconditionsmentalhealthstatusandtheseverityoflowerurinarytractsymptomsbenignprostatichyperplasiainchineseelderly AT yifanwu associationbetweenlifestylemultiplechronicconditionsmentalhealthstatusandtheseverityoflowerurinarytractsymptomsbenignprostatichyperplasiainchineseelderly AT yuweizhang associationbetweenlifestylemultiplechronicconditionsmentalhealthstatusandtheseverityoflowerurinarytractsymptomsbenignprostatichyperplasiainchineseelderly AT yuweizhang associationbetweenlifestylemultiplechronicconditionsmentalhealthstatusandtheseverityoflowerurinarytractsymptomsbenignprostatichyperplasiainchineseelderly AT xinweiliu associationbetweenlifestylemultiplechronicconditionsmentalhealthstatusandtheseverityoflowerurinarytractsymptomsbenignprostatichyperplasiainchineseelderly AT xinweiliu associationbetweenlifestylemultiplechronicconditionsmentalhealthstatusandtheseverityoflowerurinarytractsymptomsbenignprostatichyperplasiainchineseelderly AT yongnenghuang associationbetweenlifestylemultiplechronicconditionsmentalhealthstatusandtheseverityoflowerurinarytractsymptomsbenignprostatichyperplasiainchineseelderly AT yongnenghuang associationbetweenlifestylemultiplechronicconditionsmentalhealthstatusandtheseverityoflowerurinarytractsymptomsbenignprostatichyperplasiainchineseelderly AT yehua associationbetweenlifestylemultiplechronicconditionsmentalhealthstatusandtheseverityoflowerurinarytractsymptomsbenignprostatichyperplasiainchineseelderly AT ninghanfeng associationbetweenlifestylemultiplechronicconditionsmentalhealthstatusandtheseverityoflowerurinarytractsymptomsbenignprostatichyperplasiainchineseelderly AT ninghanfeng associationbetweenlifestylemultiplechronicconditionsmentalhealthstatusandtheseverityoflowerurinarytractsymptomsbenignprostatichyperplasiainchineseelderly |