Nuclear Magnetic Resonance Analysis Seeking for Metabolic Markers of Hypertension in Human Serum
Hypertension is a highly prevalent medical condition that occurs when blood pressure is too high, which greatly increases the risk of developing other cardiovascular diseases and is generally associated with higher rates of morbidity and mortality. Due to the silent/asymptomatic nature of hypertensi...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-05-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/30/10/2145 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850256477720150016 |
|---|---|
| author | Adriana Sousa Nádia Oliveira Ricardo Conde Elisabete Morais Ana Paula Amaral Nieves Embade Oscar Millet Ignacio Verde |
| author_facet | Adriana Sousa Nádia Oliveira Ricardo Conde Elisabete Morais Ana Paula Amaral Nieves Embade Oscar Millet Ignacio Verde |
| author_sort | Adriana Sousa |
| collection | DOAJ |
| description | Hypertension is a highly prevalent medical condition that occurs when blood pressure is too high, which greatly increases the risk of developing other cardiovascular diseases and is generally associated with higher rates of morbidity and mortality. Due to the silent/asymptomatic nature of hypertension, although the methods currently available to diagnose it are easy, they generally do not allow for an early diagnosis and an efficient prognosis to avoid irreversible damage in the medium or long term. In fact, an early diagnosis of hypertension would be crucial to decrease hypertension-associated mortality. Since metabolomics using NMR can provide a global measurement of various serum metabolites, it is very suitable for detecting novel biomarkers. We therefore analyzed serum metabolomic profiles among normotensive and hypertensive elderly individuals by NMR and identified new potential biomarkers for hypertension and associated diseases. We found higher levels of acetate, formate, and glycerol, and lower levels of glutamine, glycine, and sarcosine in individuals with hypertension. Therefore, these metabolites could be used for early diagnosis of hypertension to avoid comorbidities derived from hypertension and associated mortality. |
| format | Article |
| id | doaj-art-dda9b0f6338341ea985fece5365d9fe5 |
| institution | OA Journals |
| issn | 1420-3049 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-dda9b0f6338341ea985fece5365d9fe52025-08-20T01:56:38ZengMDPI AGMolecules1420-30492025-05-013010214510.3390/molecules30102145Nuclear Magnetic Resonance Analysis Seeking for Metabolic Markers of Hypertension in Human SerumAdriana Sousa0Nádia Oliveira1Ricardo Conde2Elisabete Morais3Ana Paula Amaral4Nieves Embade5Oscar Millet6Ignacio Verde7Health Sciences Research Centre (CICS-UBI), University of Beira Interior (UBI), 6200-506 Covilhã, PortugalHealth Sciences Research Centre (CICS-UBI), University of Beira Interior (UBI), 6200-506 Covilhã, PortugalHealth Sciences Research Centre (CICS-UBI), University of Beira Interior (UBI), 6200-506 Covilhã, PortugalHealth Sciences Research Centre (CICS-UBI), University of Beira Interior (UBI), 6200-506 Covilhã, PortugalHealth Sciences Research Centre (CICS-UBI), University of Beira Interior (UBI), 6200-506 Covilhã, PortugalCenter for Cooperative Research in Biosciences (CIC-BioGUNE), Bizkaia Science and Technology Park, 48160 Derio, SpainCenter for Cooperative Research in Biosciences (CIC-BioGUNE), Bizkaia Science and Technology Park, 48160 Derio, SpainHealth Sciences Research Centre (CICS-UBI), University of Beira Interior (UBI), 6200-506 Covilhã, PortugalHypertension is a highly prevalent medical condition that occurs when blood pressure is too high, which greatly increases the risk of developing other cardiovascular diseases and is generally associated with higher rates of morbidity and mortality. Due to the silent/asymptomatic nature of hypertension, although the methods currently available to diagnose it are easy, they generally do not allow for an early diagnosis and an efficient prognosis to avoid irreversible damage in the medium or long term. In fact, an early diagnosis of hypertension would be crucial to decrease hypertension-associated mortality. Since metabolomics using NMR can provide a global measurement of various serum metabolites, it is very suitable for detecting novel biomarkers. We therefore analyzed serum metabolomic profiles among normotensive and hypertensive elderly individuals by NMR and identified new potential biomarkers for hypertension and associated diseases. We found higher levels of acetate, formate, and glycerol, and lower levels of glutamine, glycine, and sarcosine in individuals with hypertension. Therefore, these metabolites could be used for early diagnosis of hypertension to avoid comorbidities derived from hypertension and associated mortality.https://www.mdpi.com/1420-3049/30/10/2145hypertensionbiomarkersagingNMRmetabolomics |
| spellingShingle | Adriana Sousa Nádia Oliveira Ricardo Conde Elisabete Morais Ana Paula Amaral Nieves Embade Oscar Millet Ignacio Verde Nuclear Magnetic Resonance Analysis Seeking for Metabolic Markers of Hypertension in Human Serum Molecules hypertension biomarkers aging NMR metabolomics |
| title | Nuclear Magnetic Resonance Analysis Seeking for Metabolic Markers of Hypertension in Human Serum |
| title_full | Nuclear Magnetic Resonance Analysis Seeking for Metabolic Markers of Hypertension in Human Serum |
| title_fullStr | Nuclear Magnetic Resonance Analysis Seeking for Metabolic Markers of Hypertension in Human Serum |
| title_full_unstemmed | Nuclear Magnetic Resonance Analysis Seeking for Metabolic Markers of Hypertension in Human Serum |
| title_short | Nuclear Magnetic Resonance Analysis Seeking for Metabolic Markers of Hypertension in Human Serum |
| title_sort | nuclear magnetic resonance analysis seeking for metabolic markers of hypertension in human serum |
| topic | hypertension biomarkers aging NMR metabolomics |
| url | https://www.mdpi.com/1420-3049/30/10/2145 |
| work_keys_str_mv | AT adrianasousa nuclearmagneticresonanceanalysisseekingformetabolicmarkersofhypertensioninhumanserum AT nadiaoliveira nuclearmagneticresonanceanalysisseekingformetabolicmarkersofhypertensioninhumanserum AT ricardoconde nuclearmagneticresonanceanalysisseekingformetabolicmarkersofhypertensioninhumanserum AT elisabetemorais nuclearmagneticresonanceanalysisseekingformetabolicmarkersofhypertensioninhumanserum AT anapaulaamaral nuclearmagneticresonanceanalysisseekingformetabolicmarkersofhypertensioninhumanserum AT nievesembade nuclearmagneticresonanceanalysisseekingformetabolicmarkersofhypertensioninhumanserum AT oscarmillet nuclearmagneticresonanceanalysisseekingformetabolicmarkersofhypertensioninhumanserum AT ignacioverde nuclearmagneticresonanceanalysisseekingformetabolicmarkersofhypertensioninhumanserum |