Pharmacologically targeting Schwann cells to improve regeneration following nerve damage
Schwann cells provide essential support for nerve growth and survival following peripheral nerve damage by producing various growth factors and other signalling molecules. Modulating the proliferation, differentiation, migration, or myelination of Schwann cells could result in accelerated repair and...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2025.1603752/full |
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| author | Alaa A. Alhamdi Alaa A. Alhamdi Shona Mackie Shona Mackie Ryan P. Trueman Ryan P. Trueman Melissa L. D. Rayner Melissa L. D. Rayner |
| author_facet | Alaa A. Alhamdi Alaa A. Alhamdi Shona Mackie Shona Mackie Ryan P. Trueman Ryan P. Trueman Melissa L. D. Rayner Melissa L. D. Rayner |
| author_sort | Alaa A. Alhamdi |
| collection | DOAJ |
| description | Schwann cells provide essential support for nerve growth and survival following peripheral nerve damage by producing various growth factors and other signalling molecules. Modulating the proliferation, differentiation, migration, or myelination of Schwann cells could result in accelerated repair and regeneration of injured nerves, ultimately leading to improved motor and sensory function. Therefore, Schwann cells are commonly advocated as therapeutic targets for nerve damage, which could be mediated by pharmacological intervention. This review discusses how compounds such as growth factors, hormones, and small molecules can regulate intracellular signalling pathways involved in modulating Schwann cells. |
| format | Article |
| id | doaj-art-dda73035cd57435ebebb63675d134d8f |
| institution | DOAJ |
| issn | 2296-634X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-dda73035cd57435ebebb63675d134d8f2025-08-20T03:22:11ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2025-06-011310.3389/fcell.2025.16037521603752Pharmacologically targeting Schwann cells to improve regeneration following nerve damageAlaa A. Alhamdi0Alaa A. Alhamdi1Shona Mackie2Shona Mackie3Ryan P. Trueman4Ryan P. Trueman5Melissa L. D. Rayner6Melissa L. D. Rayner7Department of Pharmacology, UCL School of Pharmacy, University College London, London, United KingdomUCL Centre for Nerve Engineering, University College London, London, United KingdomDepartment of Pharmacology, UCL School of Pharmacy, University College London, London, United KingdomUCL Centre for Nerve Engineering, University College London, London, United KingdomDepartment of Pharmacology, UCL School of Pharmacy, University College London, London, United KingdomUCL Centre for Nerve Engineering, University College London, London, United KingdomDepartment of Pharmacology, UCL School of Pharmacy, University College London, London, United KingdomUCL Centre for Nerve Engineering, University College London, London, United KingdomSchwann cells provide essential support for nerve growth and survival following peripheral nerve damage by producing various growth factors and other signalling molecules. Modulating the proliferation, differentiation, migration, or myelination of Schwann cells could result in accelerated repair and regeneration of injured nerves, ultimately leading to improved motor and sensory function. Therefore, Schwann cells are commonly advocated as therapeutic targets for nerve damage, which could be mediated by pharmacological intervention. This review discusses how compounds such as growth factors, hormones, and small molecules can regulate intracellular signalling pathways involved in modulating Schwann cells.https://www.frontiersin.org/articles/10.3389/fcell.2025.1603752/fullnerve regenerationSchwann cellssignalling pathwaypharmacological interventioncell phenotype |
| spellingShingle | Alaa A. Alhamdi Alaa A. Alhamdi Shona Mackie Shona Mackie Ryan P. Trueman Ryan P. Trueman Melissa L. D. Rayner Melissa L. D. Rayner Pharmacologically targeting Schwann cells to improve regeneration following nerve damage Frontiers in Cell and Developmental Biology nerve regeneration Schwann cells signalling pathway pharmacological intervention cell phenotype |
| title | Pharmacologically targeting Schwann cells to improve regeneration following nerve damage |
| title_full | Pharmacologically targeting Schwann cells to improve regeneration following nerve damage |
| title_fullStr | Pharmacologically targeting Schwann cells to improve regeneration following nerve damage |
| title_full_unstemmed | Pharmacologically targeting Schwann cells to improve regeneration following nerve damage |
| title_short | Pharmacologically targeting Schwann cells to improve regeneration following nerve damage |
| title_sort | pharmacologically targeting schwann cells to improve regeneration following nerve damage |
| topic | nerve regeneration Schwann cells signalling pathway pharmacological intervention cell phenotype |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2025.1603752/full |
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