Proteome‐Wide Mendelian Randomization Identifies Candidate Causal Proteins for Cardiovascular Diseases

Proteome‐Wide Mendelian Randomization Identifies Candidate Causal Proteins for Cardiovascular Diseases

Abstract Integration of human genomics and other omics across different ancestries provides novel, affordable, and systematic approach for target identification. We used Mendelian randomization approaches to unravel causal associations between 2,940 circulating proteins and 19 CVD. We found 218 prot...

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Main Authors: Chen Li, Nicolas De Jay, Shan‐Shan Zhang, Xin Fang, Supriya Sharma, Katrina A. Catalano, Venkatesh Sridharan, Zhaoqing Wang, Lei Zhao, Joseph D. Szustakowski, Ching‐Pin Chang, Joseph C. Maranville, Emily R. Holzinger, Erika M. Kvikstad
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:Advanced Genetics
Subjects:
cardiovascular diseases
Mendelian randomization
multi‐omics
proteome‐wide
single cell
Online Access:https://doi.org/10.1002/ggn2.202500003
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