Clinical and pre-clinical advances in the PDT/PTT strategy for diagnosis and treatment of cancer
Photodynamic therapy (PDT) and photothermal therapy (PTT) have demonstrated great potential to diagnose and combat localized cancers. As a matter of fact, these techniques are less invasive and have fewer side effects than traditional cancer treatments like surgery, chemotherapy or radiotherapy. Thi...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Photodiagnosis and Photodynamic Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1572100024004241 |
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| author | Coralía Fabiola Cuadrado Karina J. Lagos Mirian Denise Stringasci Vanderlei Salvador Bagnato María Paulina Romero |
| author_facet | Coralía Fabiola Cuadrado Karina J. Lagos Mirian Denise Stringasci Vanderlei Salvador Bagnato María Paulina Romero |
| author_sort | Coralía Fabiola Cuadrado |
| collection | DOAJ |
| description | Photodynamic therapy (PDT) and photothermal therapy (PTT) have demonstrated great potential to diagnose and combat localized cancers. As a matter of fact, these techniques are less invasive and have fewer side effects than traditional cancer treatments like surgery, chemotherapy or radiotherapy. This review summarizes the clinical progress in the theranostics (diagnosis and treatment) of various types of regional cancers using these two light stimuli techniques, PDT and PTT. Therefore, clinical advances in cancer diagnosis based on PDT are detailed, including fluorescence-guided PDT for intraoperative cancer detection, optical coherence tomography (OCT)-guided PDT for early cancer detection, and imaging by magnetic resonance imaging (MRI) or computed tomography (CT) assisted through PDT/PTT. Moreover, clinical studies of breast, prostate, skin, gynecologic, head, neck and other varieties of cancer have been addressed to compare the main conditions of these treatments. This work also discussed the principal advantages and drawbacks of PDT and PTT in tumor targeting and cancer therapy. Finally, the usage of nanoparticles as photosensitizers (PSs) and photothermal agents (PAs) have been analyzed. In this manner, the authors have compiled relevant updated studies so that researchers interested in these areas can access it speedily. |
| format | Article |
| id | doaj-art-dd9f794439ea48bfb6b33d71f4299634 |
| institution | OA Journals |
| issn | 1572-1000 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photodiagnosis and Photodynamic Therapy |
| spelling | doaj-art-dd9f794439ea48bfb6b33d71f42996342025-08-20T01:59:30ZengElsevierPhotodiagnosis and Photodynamic Therapy1572-10002024-12-015010438710.1016/j.pdpdt.2024.104387Clinical and pre-clinical advances in the PDT/PTT strategy for diagnosis and treatment of cancerCoralía Fabiola Cuadrado0Karina J. Lagos1Mirian Denise Stringasci2Vanderlei Salvador Bagnato3María Paulina Romero4New Materials Laboratory, Department of Materials, National Polytechnic School, Quito, EcuadorNew Materials Laboratory, Department of Materials, National Polytechnic School, Quito, EcuadorSão Carlos Institute of Physics, University of São Paulo, São Carlos, BrazilSão Carlos Institute of Physics, University of São Paulo, São Carlos, BrazilNew Materials Laboratory, Department of Materials, National Polytechnic School, Quito, Ecuador; Corresponding author.Photodynamic therapy (PDT) and photothermal therapy (PTT) have demonstrated great potential to diagnose and combat localized cancers. As a matter of fact, these techniques are less invasive and have fewer side effects than traditional cancer treatments like surgery, chemotherapy or radiotherapy. This review summarizes the clinical progress in the theranostics (diagnosis and treatment) of various types of regional cancers using these two light stimuli techniques, PDT and PTT. Therefore, clinical advances in cancer diagnosis based on PDT are detailed, including fluorescence-guided PDT for intraoperative cancer detection, optical coherence tomography (OCT)-guided PDT for early cancer detection, and imaging by magnetic resonance imaging (MRI) or computed tomography (CT) assisted through PDT/PTT. Moreover, clinical studies of breast, prostate, skin, gynecologic, head, neck and other varieties of cancer have been addressed to compare the main conditions of these treatments. This work also discussed the principal advantages and drawbacks of PDT and PTT in tumor targeting and cancer therapy. Finally, the usage of nanoparticles as photosensitizers (PSs) and photothermal agents (PAs) have been analyzed. In this manner, the authors have compiled relevant updated studies so that researchers interested in these areas can access it speedily.http://www.sciencedirect.com/science/article/pii/S1572100024004241Malignant tumorLocalized cancerLight stimuli therapyNon-invasive treatmentPhotodynamic therapyPhotothermal therapy |
| spellingShingle | Coralía Fabiola Cuadrado Karina J. Lagos Mirian Denise Stringasci Vanderlei Salvador Bagnato María Paulina Romero Clinical and pre-clinical advances in the PDT/PTT strategy for diagnosis and treatment of cancer Photodiagnosis and Photodynamic Therapy Malignant tumor Localized cancer Light stimuli therapy Non-invasive treatment Photodynamic therapy Photothermal therapy |
| title | Clinical and pre-clinical advances in the PDT/PTT strategy for diagnosis and treatment of cancer |
| title_full | Clinical and pre-clinical advances in the PDT/PTT strategy for diagnosis and treatment of cancer |
| title_fullStr | Clinical and pre-clinical advances in the PDT/PTT strategy for diagnosis and treatment of cancer |
| title_full_unstemmed | Clinical and pre-clinical advances in the PDT/PTT strategy for diagnosis and treatment of cancer |
| title_short | Clinical and pre-clinical advances in the PDT/PTT strategy for diagnosis and treatment of cancer |
| title_sort | clinical and pre clinical advances in the pdt ptt strategy for diagnosis and treatment of cancer |
| topic | Malignant tumor Localized cancer Light stimuli therapy Non-invasive treatment Photodynamic therapy Photothermal therapy |
| url | http://www.sciencedirect.com/science/article/pii/S1572100024004241 |
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