A Narrative Review: Relationship Between Glycemic Variability and Emerging Complications of Diabetes Mellitus
A growing body of evidence emphasizes the role of glycemic variability (GV) in the development of conventional diabetes-related complications. Furthermore, advancements in diabetes management and increased life expectancy have led to the emergence of new complications, such as cancer, liver disease,...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-01-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/15/2/188 |
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| author | Xinxin Wang Yanli Cao |
| author_facet | Xinxin Wang Yanli Cao |
| author_sort | Xinxin Wang |
| collection | DOAJ |
| description | A growing body of evidence emphasizes the role of glycemic variability (GV) in the development of conventional diabetes-related complications. Furthermore, advancements in diabetes management and increased life expectancy have led to the emergence of new complications, such as cancer, liver disease, fractures, infections, and cognitive dysfunction. GV is considered to exacerbate oxidative stress and inflammation, acting as a major mechanism underlying these complications. However, few reviews have synthesized the association between GV and these emerging complications or examined their underlying mechanisms. Hence, this narrative review provides a comprehensive discussion of the burden, risks, and mechanisms of GV in these complications, offering further evidence supporting GV as a potential therapeutic target for diabetes management. |
| format | Article |
| id | doaj-art-dd9eeaa81ac044a2b99a38f229602987 |
| institution | DOAJ |
| issn | 2218-273X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj-art-dd9eeaa81ac044a2b99a38f2296029872025-08-20T02:44:59ZengMDPI AGBiomolecules2218-273X2025-01-0115218810.3390/biom15020188A Narrative Review: Relationship Between Glycemic Variability and Emerging Complications of Diabetes MellitusXinxin Wang0Yanli Cao1Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Affiliated Hospital of China Medical University, Shenyang 110001, ChinaDepartment of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Affiliated Hospital of China Medical University, Shenyang 110001, ChinaA growing body of evidence emphasizes the role of glycemic variability (GV) in the development of conventional diabetes-related complications. Furthermore, advancements in diabetes management and increased life expectancy have led to the emergence of new complications, such as cancer, liver disease, fractures, infections, and cognitive dysfunction. GV is considered to exacerbate oxidative stress and inflammation, acting as a major mechanism underlying these complications. However, few reviews have synthesized the association between GV and these emerging complications or examined their underlying mechanisms. Hence, this narrative review provides a comprehensive discussion of the burden, risks, and mechanisms of GV in these complications, offering further evidence supporting GV as a potential therapeutic target for diabetes management.https://www.mdpi.com/2218-273X/15/2/188glycemic variabilityoxidative stressdiabetesemerging complications |
| spellingShingle | Xinxin Wang Yanli Cao A Narrative Review: Relationship Between Glycemic Variability and Emerging Complications of Diabetes Mellitus Biomolecules glycemic variability oxidative stress diabetes emerging complications |
| title | A Narrative Review: Relationship Between Glycemic Variability and Emerging Complications of Diabetes Mellitus |
| title_full | A Narrative Review: Relationship Between Glycemic Variability and Emerging Complications of Diabetes Mellitus |
| title_fullStr | A Narrative Review: Relationship Between Glycemic Variability and Emerging Complications of Diabetes Mellitus |
| title_full_unstemmed | A Narrative Review: Relationship Between Glycemic Variability and Emerging Complications of Diabetes Mellitus |
| title_short | A Narrative Review: Relationship Between Glycemic Variability and Emerging Complications of Diabetes Mellitus |
| title_sort | narrative review relationship between glycemic variability and emerging complications of diabetes mellitus |
| topic | glycemic variability oxidative stress diabetes emerging complications |
| url | https://www.mdpi.com/2218-273X/15/2/188 |
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