Hypocalcemia was associated with increased perioperative blood loss and blood transfusion in elderly patients with hip fracture: a retrospective study
Abstract Background Serum calcium is the critical coagulation factor in physiological coagulation, and hypocalcemia has been found to be associated with more blood loss in many diseases. The purpose of this study was to explore the effect of hypocalcemia on total blood loss (TBL) and blood transfusi...
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BMC
2025-04-01
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| Series: | BMC Surgery |
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| Online Access: | https://doi.org/10.1186/s12893-025-02872-2 |
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| author | Yunqing Zhang Kun Lu Qi Liu Chun Liu Shilong Su Chunhua Yang |
| author_facet | Yunqing Zhang Kun Lu Qi Liu Chun Liu Shilong Su Chunhua Yang |
| author_sort | Yunqing Zhang |
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| description | Abstract Background Serum calcium is the critical coagulation factor in physiological coagulation, and hypocalcemia has been found to be associated with more blood loss in many diseases. The purpose of this study was to explore the effect of hypocalcemia on total blood loss (TBL) and blood transfusion in elderly patients with hip fracture. Patients and methods Elderly patients with hip fracture undergoing surgery in our hospital were included in this study from January 2020 to May 2023. The demographic data, perioperative parameters, hemoglobin, hematocrit, and transfusion requirement were recorded and analyzed. Hypocalcemia was defined as an albumin-corrected calcium level of less than 2.15 mmol/L. TBL of each patient was calculated using the formulas of Nadler and Gross. Blood loss on the 1st and 5th postoperative days was calculated. Results 682 elderly patients with hip fracture were included in the study. On admission, the prevalence of hypocalcemia was 40.47%. Both the TBL on the first day (714.91 ± 396.05 ml vs. 640.31 ± 398.83 ml, P = 0.016) and the fifth day (1035.87 ± 528.77 ml vs. 859.92 ± 434.99 ml, P < 0.001) after operation in the hypocalcemia group were higher than those in the normocalcemia group. The preoperative, postoperative and perioperative blood transfusion rates of hypocalcemia patients were higher than those of the normocalcemia group. Conclusion Hypocalcemia was associated with increased TBL and blood transfusion in elderly patients with hip fracture during the perioperative period. |
| format | Article |
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| institution | OA Journals |
| issn | 1471-2482 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
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| series | BMC Surgery |
| spelling | doaj-art-dd94aefbfdce4b8cb6bcf29ab365d6142025-08-20T01:53:04ZengBMCBMC Surgery1471-24822025-04-012511710.1186/s12893-025-02872-2Hypocalcemia was associated with increased perioperative blood loss and blood transfusion in elderly patients with hip fracture: a retrospective studyYunqing Zhang0Kun Lu1Qi Liu2Chun Liu3Shilong Su4Chunhua Yang5Department of Orthopedics, The First Hospital of ChangshaDepartment of Orthopedics, The First Hospital of ChangshaDepartment of Orthopedics, The First Hospital of ChangshaDepartment of Orthopedics, The First Hospital of ChangshaDepartment of Orthopedics, Peking University Third HospitalDepartment of Orthopedics, The First Hospital of ChangshaAbstract Background Serum calcium is the critical coagulation factor in physiological coagulation, and hypocalcemia has been found to be associated with more blood loss in many diseases. The purpose of this study was to explore the effect of hypocalcemia on total blood loss (TBL) and blood transfusion in elderly patients with hip fracture. Patients and methods Elderly patients with hip fracture undergoing surgery in our hospital were included in this study from January 2020 to May 2023. The demographic data, perioperative parameters, hemoglobin, hematocrit, and transfusion requirement were recorded and analyzed. Hypocalcemia was defined as an albumin-corrected calcium level of less than 2.15 mmol/L. TBL of each patient was calculated using the formulas of Nadler and Gross. Blood loss on the 1st and 5th postoperative days was calculated. Results 682 elderly patients with hip fracture were included in the study. On admission, the prevalence of hypocalcemia was 40.47%. Both the TBL on the first day (714.91 ± 396.05 ml vs. 640.31 ± 398.83 ml, P = 0.016) and the fifth day (1035.87 ± 528.77 ml vs. 859.92 ± 434.99 ml, P < 0.001) after operation in the hypocalcemia group were higher than those in the normocalcemia group. The preoperative, postoperative and perioperative blood transfusion rates of hypocalcemia patients were higher than those of the normocalcemia group. Conclusion Hypocalcemia was associated with increased TBL and blood transfusion in elderly patients with hip fracture during the perioperative period.https://doi.org/10.1186/s12893-025-02872-2HypocalcemiaElderlyHip fractureBlood lossBlood transfusion |
| spellingShingle | Yunqing Zhang Kun Lu Qi Liu Chun Liu Shilong Su Chunhua Yang Hypocalcemia was associated with increased perioperative blood loss and blood transfusion in elderly patients with hip fracture: a retrospective study BMC Surgery Hypocalcemia Elderly Hip fracture Blood loss Blood transfusion |
| title | Hypocalcemia was associated with increased perioperative blood loss and blood transfusion in elderly patients with hip fracture: a retrospective study |
| title_full | Hypocalcemia was associated with increased perioperative blood loss and blood transfusion in elderly patients with hip fracture: a retrospective study |
| title_fullStr | Hypocalcemia was associated with increased perioperative blood loss and blood transfusion in elderly patients with hip fracture: a retrospective study |
| title_full_unstemmed | Hypocalcemia was associated with increased perioperative blood loss and blood transfusion in elderly patients with hip fracture: a retrospective study |
| title_short | Hypocalcemia was associated with increased perioperative blood loss and blood transfusion in elderly patients with hip fracture: a retrospective study |
| title_sort | hypocalcemia was associated with increased perioperative blood loss and blood transfusion in elderly patients with hip fracture a retrospective study |
| topic | Hypocalcemia Elderly Hip fracture Blood loss Blood transfusion |
| url | https://doi.org/10.1186/s12893-025-02872-2 |
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