Infliximab Salvage Therapy after Cyclosporine in an Acute Flare of Chronic Ulcerative Colitis
Although infliximab (Remicade, Schering Canada Inc, Quebec) therapy has been well studied in steroid refractory Crohn’s disease, its use remains controversial in chronic ulcerative colitis. A 24-year-old woman with a 14-year history of well controlled left sided ulcerative colitis presented with an...
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| Format: | Article |
| Language: | English |
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Wiley
2003-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2003/470210 |
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| author | ECS Lam RJ Bailey |
| author_facet | ECS Lam RJ Bailey |
| author_sort | ECS Lam |
| collection | DOAJ |
| description | Although infliximab (Remicade, Schering Canada Inc, Quebec) therapy has been well studied in steroid refractory Crohn’s disease, its use remains controversial in chronic ulcerative colitis. A 24-year-old woman with a 14-year history of well controlled left sided ulcerative colitis presented with an acute flare. Clinical, endoscopic and biopsy evidence of an acute flare of ulcerative pancolitis were present. There was no response to intravenous steroids but improvement was seen after receiving 14 days of intravenous cyclosporine (4 mg/kg/day continuous infusion). The patient was discharged from hospital with azathioprine (2.5 mg/kg/day) and low dose oral cyclosporine (4 mg/kg/day). She presented with worsening symptoms seven days after discharge. Because of the patient’s unwillingness for surgery, she instead received two injections of infliximab 5 mg/kg at week 0 and week 2. An initial response occurred, but her clinical improvement was not durable. Colectomy was performed four weeks later. This is the first report of infliximab as a salvage therapy in an acute flare of chronic ulcerative colitis following failure of cyclosporine. |
| format | Article |
| id | doaj-art-dd9239034cbf4fdc9b96da16483895ad |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 2003-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-dd9239034cbf4fdc9b96da16483895ad2025-02-03T05:57:38ZengWileyCanadian Journal of Gastroenterology0835-79002003-01-0117319820010.1155/2003/470210Infliximab Salvage Therapy after Cyclosporine in an Acute Flare of Chronic Ulcerative ColitisECS Lam0RJ Bailey1Department of Medicine, University of Alberta, CanadaDepartment of Medicine, Royal Alexandra Hospital, Edmonton, Alberta, CanadaAlthough infliximab (Remicade, Schering Canada Inc, Quebec) therapy has been well studied in steroid refractory Crohn’s disease, its use remains controversial in chronic ulcerative colitis. A 24-year-old woman with a 14-year history of well controlled left sided ulcerative colitis presented with an acute flare. Clinical, endoscopic and biopsy evidence of an acute flare of ulcerative pancolitis were present. There was no response to intravenous steroids but improvement was seen after receiving 14 days of intravenous cyclosporine (4 mg/kg/day continuous infusion). The patient was discharged from hospital with azathioprine (2.5 mg/kg/day) and low dose oral cyclosporine (4 mg/kg/day). She presented with worsening symptoms seven days after discharge. Because of the patient’s unwillingness for surgery, she instead received two injections of infliximab 5 mg/kg at week 0 and week 2. An initial response occurred, but her clinical improvement was not durable. Colectomy was performed four weeks later. This is the first report of infliximab as a salvage therapy in an acute flare of chronic ulcerative colitis following failure of cyclosporine.http://dx.doi.org/10.1155/2003/470210 |
| spellingShingle | ECS Lam RJ Bailey Infliximab Salvage Therapy after Cyclosporine in an Acute Flare of Chronic Ulcerative Colitis Canadian Journal of Gastroenterology |
| title | Infliximab Salvage Therapy after Cyclosporine in an Acute Flare of Chronic Ulcerative Colitis |
| title_full | Infliximab Salvage Therapy after Cyclosporine in an Acute Flare of Chronic Ulcerative Colitis |
| title_fullStr | Infliximab Salvage Therapy after Cyclosporine in an Acute Flare of Chronic Ulcerative Colitis |
| title_full_unstemmed | Infliximab Salvage Therapy after Cyclosporine in an Acute Flare of Chronic Ulcerative Colitis |
| title_short | Infliximab Salvage Therapy after Cyclosporine in an Acute Flare of Chronic Ulcerative Colitis |
| title_sort | infliximab salvage therapy after cyclosporine in an acute flare of chronic ulcerative colitis |
| url | http://dx.doi.org/10.1155/2003/470210 |
| work_keys_str_mv | AT ecslam infliximabsalvagetherapyaftercyclosporineinanacuteflareofchroniculcerativecolitis AT rjbailey infliximabsalvagetherapyaftercyclosporineinanacuteflareofchroniculcerativecolitis |