Impact of polycyclic aromatic hydrocarbon exposure on thyroid hormone sensitivity: a cross-sectional study of urinary metabolites in 2356 adults from NHANES
Objective The current study aimed to compare the relationship between polycyclic aromatic hydrocarbons (PAHs) exposure and thyroid hormone (TH) sensitivity markers in individuals with normal thyroid function in the USA population during 2007–2008 and 2009–2012.Design Observational cross-sectional st...
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| Format: | Article |
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BMJ Publishing Group
2025-05-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/15/5/e098106.full |
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| author | Min Li Hui Li Qingqing Yang Chenchen Wu Weihua Sun Xiaolei Hu Zhaoming Shi Guoxi Jin |
| author_facet | Min Li Hui Li Qingqing Yang Chenchen Wu Weihua Sun Xiaolei Hu Zhaoming Shi Guoxi Jin |
| author_sort | Min Li |
| collection | DOAJ |
| description | Objective The current study aimed to compare the relationship between polycyclic aromatic hydrocarbons (PAHs) exposure and thyroid hormone (TH) sensitivity markers in individuals with normal thyroid function in the USA population during 2007–2008 and 2009–2012.Design Observational cross-sectional study.Setting US population data from 2007 to 2008 and 2009 to 2012.Main outcome measures Associations between PAH exposure and TH sensitivity were examined, stratified by sex and age, along with dose–response relationships between PAH metabolites and TH sensitivity indices.Results In women, after adjusting for confounding variables, 1-hydroxynaphthalene was positively associated with thyroid feedback quantile index of FT4 (TFQIFT4) (β=0.0072, 95% CI 0.0018 to 0.0127, p=0.022), thyrotropin thyroxine resistance index (TT4RI) (β=0.0099, 95% CI 0.0024 to 0.0173, p=0.021) and thyroid-stimulating hormone index (TSHI) (β=0.0107, 95% CI 0.0038 to 0.0176, p=0.012). Among individuals aged 60 years and older, 1-hydroxyphenanthrene was negatively associated with free triiodothyronine/free thyroxine (FT3/FT4) (β = –0.9328, 95% CI –1.5055 to –0.3602, p=0.014). Dose–response analysis revealed no nonlinear relationships between PAH metabolites and TH sensitivity indices in women or individuals aged 60 years and older. Weighted quantile regression analysis demonstrated that OH-PAHs exerted a statistically significant effect (p<0.05) on TH sensitivity indices, including TFQIFT4, thyroid feedback quantile index of FT3, TT4RI, hyrotropin triiodothyronine resistance index and TSHI.Conclusions In the US population with normal thyroid function, PAH exposure may interfere with TH sensitivity, with effects varying by population characteristics. |
| format | Article |
| id | doaj-art-dd91936737b94ef4939515e7ff6a99a7 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-dd91936737b94ef4939515e7ff6a99a72025-08-20T03:48:15ZengBMJ Publishing GroupBMJ Open2044-60552025-05-0115510.1136/bmjopen-2024-098106Impact of polycyclic aromatic hydrocarbon exposure on thyroid hormone sensitivity: a cross-sectional study of urinary metabolites in 2356 adults from NHANESMin Li0Hui Li1Qingqing Yang2Chenchen Wu3Weihua Sun4Xiaolei Hu5Zhaoming Shi6Guoxi Jin7Department of Endocrinology, The First Affiliated Hospital of Bengbu Medical University, Bengbu, ChinaDepartment of Cardiology, The First Affiliated Hospital of Bengbu Medical University, Bengbu, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Bengbu Medical University, Bengbu, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Bengbu Medical University, Bengbu, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Bengbu Medical University, Bengbu, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Bengbu Medical University, Bengbu, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Bengbu Medical University, Bengbu, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Bengbu Medical University, Bengbu, ChinaObjective The current study aimed to compare the relationship between polycyclic aromatic hydrocarbons (PAHs) exposure and thyroid hormone (TH) sensitivity markers in individuals with normal thyroid function in the USA population during 2007–2008 and 2009–2012.Design Observational cross-sectional study.Setting US population data from 2007 to 2008 and 2009 to 2012.Main outcome measures Associations between PAH exposure and TH sensitivity were examined, stratified by sex and age, along with dose–response relationships between PAH metabolites and TH sensitivity indices.Results In women, after adjusting for confounding variables, 1-hydroxynaphthalene was positively associated with thyroid feedback quantile index of FT4 (TFQIFT4) (β=0.0072, 95% CI 0.0018 to 0.0127, p=0.022), thyrotropin thyroxine resistance index (TT4RI) (β=0.0099, 95% CI 0.0024 to 0.0173, p=0.021) and thyroid-stimulating hormone index (TSHI) (β=0.0107, 95% CI 0.0038 to 0.0176, p=0.012). Among individuals aged 60 years and older, 1-hydroxyphenanthrene was negatively associated with free triiodothyronine/free thyroxine (FT3/FT4) (β = –0.9328, 95% CI –1.5055 to –0.3602, p=0.014). Dose–response analysis revealed no nonlinear relationships between PAH metabolites and TH sensitivity indices in women or individuals aged 60 years and older. Weighted quantile regression analysis demonstrated that OH-PAHs exerted a statistically significant effect (p<0.05) on TH sensitivity indices, including TFQIFT4, thyroid feedback quantile index of FT3, TT4RI, hyrotropin triiodothyronine resistance index and TSHI.Conclusions In the US population with normal thyroid function, PAH exposure may interfere with TH sensitivity, with effects varying by population characteristics.https://bmjopen.bmj.com/content/15/5/e098106.full |
| spellingShingle | Min Li Hui Li Qingqing Yang Chenchen Wu Weihua Sun Xiaolei Hu Zhaoming Shi Guoxi Jin Impact of polycyclic aromatic hydrocarbon exposure on thyroid hormone sensitivity: a cross-sectional study of urinary metabolites in 2356 adults from NHANES BMJ Open |
| title | Impact of polycyclic aromatic hydrocarbon exposure on thyroid hormone sensitivity: a cross-sectional study of urinary metabolites in 2356 adults from NHANES |
| title_full | Impact of polycyclic aromatic hydrocarbon exposure on thyroid hormone sensitivity: a cross-sectional study of urinary metabolites in 2356 adults from NHANES |
| title_fullStr | Impact of polycyclic aromatic hydrocarbon exposure on thyroid hormone sensitivity: a cross-sectional study of urinary metabolites in 2356 adults from NHANES |
| title_full_unstemmed | Impact of polycyclic aromatic hydrocarbon exposure on thyroid hormone sensitivity: a cross-sectional study of urinary metabolites in 2356 adults from NHANES |
| title_short | Impact of polycyclic aromatic hydrocarbon exposure on thyroid hormone sensitivity: a cross-sectional study of urinary metabolites in 2356 adults from NHANES |
| title_sort | impact of polycyclic aromatic hydrocarbon exposure on thyroid hormone sensitivity a cross sectional study of urinary metabolites in 2356 adults from nhanes |
| url | https://bmjopen.bmj.com/content/15/5/e098106.full |
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