Assessment of Serum Levels of Total Bile Acids in Chronic Kidney Disease Patients on Hemodialysis with and without Uremic Pruritus
Chronic kidney disease patients undergoing hemodialysis are frequently suffering from uremic pruritus, which can be quite uncomfortable. Uremic pruritus affects over 40% of hemodialysis patients. Bile acids have been implicated in the pathogenesis of pruritus; especially in conditions associated wi...
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College of Pharmacy University of Baghdad
2025-02-01
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| Series: | Iraqi Journal of Pharmaceutical Sciences |
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| Online Access: | https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/3611 |
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| author | Mustafa Sh. Abdulqahar Ali A. Kasim |
| author_facet | Mustafa Sh. Abdulqahar Ali A. Kasim |
| author_sort | Mustafa Sh. Abdulqahar |
| collection | DOAJ |
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Chronic kidney disease patients undergoing hemodialysis are frequently suffering from uremic pruritus, which can be quite uncomfortable. Uremic pruritus affects over 40% of hemodialysis patients. Bile acids have been implicated in the pathogenesis of pruritus; especially in conditions associated with cholestasis. The purpose of the study is to investigate the serum levels of total bile acids in chronic kidney disease patients on hemodialysis, with and without uremic pruritus. Ninety adults, chronic kidney disease patients who were on chronic hemodialysis at the hemodialysis unit at Al-Fallujah Teaching Hospital in Fallujah City, Iraq, were involved. Patients were grouped equally in two groups; according to the presence or absence of pruritus, based on the itching severity scale. Serum levels of total bile acids, urea, creatinine, calcium, phosphorus, and intact parathormone were measured before and after the hemodialysis session. The serum level of total bile acids [median (IQR)], in the pre-dialysis (session samples, were non-significantly higher in patients with uremic pruritus compared to those without uremic pruritus [179.89(40.8) µmol/L and 175.28 (34.2) µmol/L; respectively]; P=0.56. Serum levels of total bile acids were not correlated with the patient's age, sex, and serum levels of urea, creatinine, calcium, phosphorous, or intact parathormone; p>0.05. Finally, serum levels of total bile acids were reduced by dialysis, and the serum levels of patients with uremic pruritus were significantly higher than those in patients without uremic pruritus in the post-dialysis session samples [133.99(23.69) µmol/L and 122.60(21.41) µmol/L; respectively]; P=0.001. In conclusion, targeting serum levels of bile acids might alleviate pruritus in chronic kidney disease patients on hemodialysis.
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| format | Article |
| id | doaj-art-dd8f52841def4e08b5f3d06e9ed8e08c |
| institution | DOAJ |
| issn | 1683-3597 2521-3512 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | College of Pharmacy University of Baghdad |
| record_format | Article |
| series | Iraqi Journal of Pharmaceutical Sciences |
| spelling | doaj-art-dd8f52841def4e08b5f3d06e9ed8e08c2025-08-20T02:48:28ZengCollege of Pharmacy University of BaghdadIraqi Journal of Pharmaceutical Sciences1683-35972521-35122025-02-0133(4SI)10.31351/vol33iss(4SI)pp179-186Assessment of Serum Levels of Total Bile Acids in Chronic Kidney Disease Patients on Hemodialysis with and without Uremic PruritusMustafa Sh. Abdulqahar0Ali A. Kasim1Ministry of Health, Anbar Health Directorate, AL-Fallujah Teaching Hospital for Maternity and Children, Anbar, Iraq.Department of Clinical Laboratory Science, College of Pharmacy, University of Baghdad, Baghdad, Iraq. Chronic kidney disease patients undergoing hemodialysis are frequently suffering from uremic pruritus, which can be quite uncomfortable. Uremic pruritus affects over 40% of hemodialysis patients. Bile acids have been implicated in the pathogenesis of pruritus; especially in conditions associated with cholestasis. The purpose of the study is to investigate the serum levels of total bile acids in chronic kidney disease patients on hemodialysis, with and without uremic pruritus. Ninety adults, chronic kidney disease patients who were on chronic hemodialysis at the hemodialysis unit at Al-Fallujah Teaching Hospital in Fallujah City, Iraq, were involved. Patients were grouped equally in two groups; according to the presence or absence of pruritus, based on the itching severity scale. Serum levels of total bile acids, urea, creatinine, calcium, phosphorus, and intact parathormone were measured before and after the hemodialysis session. The serum level of total bile acids [median (IQR)], in the pre-dialysis (session samples, were non-significantly higher in patients with uremic pruritus compared to those without uremic pruritus [179.89(40.8) µmol/L and 175.28 (34.2) µmol/L; respectively]; P=0.56. Serum levels of total bile acids were not correlated with the patient's age, sex, and serum levels of urea, creatinine, calcium, phosphorous, or intact parathormone; p>0.05. Finally, serum levels of total bile acids were reduced by dialysis, and the serum levels of patients with uremic pruritus were significantly higher than those in patients without uremic pruritus in the post-dialysis session samples [133.99(23.69) µmol/L and 122.60(21.41) µmol/L; respectively]; P=0.001. In conclusion, targeting serum levels of bile acids might alleviate pruritus in chronic kidney disease patients on hemodialysis. https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/3611Keywords; Total bile acids, chronic kidney disease, uremic pruritus, hemodialysis, itching. |
| spellingShingle | Mustafa Sh. Abdulqahar Ali A. Kasim Assessment of Serum Levels of Total Bile Acids in Chronic Kidney Disease Patients on Hemodialysis with and without Uremic Pruritus Iraqi Journal of Pharmaceutical Sciences Keywords; Total bile acids, chronic kidney disease, uremic pruritus, hemodialysis, itching. |
| title | Assessment of Serum Levels of Total Bile Acids in Chronic Kidney Disease Patients on Hemodialysis with and without Uremic Pruritus |
| title_full | Assessment of Serum Levels of Total Bile Acids in Chronic Kidney Disease Patients on Hemodialysis with and without Uremic Pruritus |
| title_fullStr | Assessment of Serum Levels of Total Bile Acids in Chronic Kidney Disease Patients on Hemodialysis with and without Uremic Pruritus |
| title_full_unstemmed | Assessment of Serum Levels of Total Bile Acids in Chronic Kidney Disease Patients on Hemodialysis with and without Uremic Pruritus |
| title_short | Assessment of Serum Levels of Total Bile Acids in Chronic Kidney Disease Patients on Hemodialysis with and without Uremic Pruritus |
| title_sort | assessment of serum levels of total bile acids in chronic kidney disease patients on hemodialysis with and without uremic pruritus |
| topic | Keywords; Total bile acids, chronic kidney disease, uremic pruritus, hemodialysis, itching. |
| url | https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/3611 |
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