Genetic variants and carotid atherosclerosis progression in familial hypercholesterolemia: a comprehensive review

Genetic variants and carotid atherosclerosis progression in familial hypercholesterolemia: a comprehensive review

IntroductionFamilial Hypercholesterolemia is a hereditary metabolic disorder characterized by elevated low-density lipoprotein cholesterol, as high as 1 in 250 individuals, leading to cardiovascular diseases like atherosclerosis. It's caused by autosomal dominant mutations in genes LDL receptor...

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Main Authors:	Makhabbat Bekbossynova, Tatyana Ivanova-Razumova, Yerkin Azatov, Aliya Sailybayeva, Sadyk Khamitov, Gulnur Daniyarova, Kamila Akzholova
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-05-01
Series:	Frontiers in Cardiovascular Medicine
Subjects:	familial hypercholesterolemia carotid atherosclerosis APOB LDLR cIMT
Online Access:	https://www.frontiersin.org/articles/10.3389/fcvm.2025.1526093/full
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