Population-level gut microbiome and its associations with environmental factors and metabolic disorders in Southwest China
Abstract Gut microbiota affects host health and disease. Large-scale cohorts have explored the interactions between the microbiota, host, and environment to reveal the disease-associated microbiota variation. A population-level gut metagenomic cohort is still rare in China. Here, we performed metage...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-02-01
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| Series: | npj Biofilms and Microbiomes |
| Online Access: | https://doi.org/10.1038/s41522-025-00661-6 |
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| author | Qianyu Qu Qingyu Dou Zhejun Xiang Bin Yu Lili Chen Zhenxin Fan Xing Zhao Shujuan Yang Peibin Zeng |
| author_facet | Qianyu Qu Qingyu Dou Zhejun Xiang Bin Yu Lili Chen Zhenxin Fan Xing Zhao Shujuan Yang Peibin Zeng |
| author_sort | Qianyu Qu |
| collection | DOAJ |
| description | Abstract Gut microbiota affects host health and disease. Large-scale cohorts have explored the interactions between the microbiota, host, and environment to reveal the disease-associated microbiota variation. A population-level gut metagenomic cohort is still rare in China. Here, we performed metagenomic sequencing on fecal samples from the CMEC Microbiome Project in Southwest China. In this study, we identified host socioeconomics, diet, lifestyle, and medical measurements that were significantly associated with microbiome function and composition. We revealed extensive novel associations between the host microbiome and common metabolic disorders. Our results provide new insight into associations of gut microbiota with metabolic disorders so as to support the translation of gut microbiome findings into potential clinical practice. |
| format | Article |
| id | doaj-art-dd8a0e9cbeca4de1ba21f74b13984cd4 |
| institution | Kabale University |
| issn | 2055-5008 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Biofilms and Microbiomes |
| spelling | doaj-art-dd8a0e9cbeca4de1ba21f74b13984cd42025-02-09T12:15:22ZengNature Portfolionpj Biofilms and Microbiomes2055-50082025-02-0111111510.1038/s41522-025-00661-6Population-level gut microbiome and its associations with environmental factors and metabolic disorders in Southwest ChinaQianyu Qu0Qingyu Dou1Zhejun Xiang2Bin Yu3Lili Chen4Zhenxin Fan5Xing Zhao6Shujuan Yang7Peibin Zeng8West China School of Public Health and West China Fourth Hospital, Sichuan UniversityNational Clinical Research Center of Geriatrics, Geriatric Medicine Center, West China Hospital, Sichuan UniversityWest China School of Public Health and West China Fourth Hospital, Sichuan UniversityWest China School of Public Health and West China Fourth Hospital, Sichuan UniversityWest China School of Public Health and West China Fourth Hospital, Sichuan UniversityCollege of Life Sciences, Sichuan UniversityWest China School of Public Health and West China Fourth Hospital, Sichuan UniversityWest China School of Public Health and West China Fourth Hospital, Sichuan UniversityWest China School of Public Health and West China Fourth Hospital, Sichuan UniversityAbstract Gut microbiota affects host health and disease. Large-scale cohorts have explored the interactions between the microbiota, host, and environment to reveal the disease-associated microbiota variation. A population-level gut metagenomic cohort is still rare in China. Here, we performed metagenomic sequencing on fecal samples from the CMEC Microbiome Project in Southwest China. In this study, we identified host socioeconomics, diet, lifestyle, and medical measurements that were significantly associated with microbiome function and composition. We revealed extensive novel associations between the host microbiome and common metabolic disorders. Our results provide new insight into associations of gut microbiota with metabolic disorders so as to support the translation of gut microbiome findings into potential clinical practice.https://doi.org/10.1038/s41522-025-00661-6 |
| spellingShingle | Qianyu Qu Qingyu Dou Zhejun Xiang Bin Yu Lili Chen Zhenxin Fan Xing Zhao Shujuan Yang Peibin Zeng Population-level gut microbiome and its associations with environmental factors and metabolic disorders in Southwest China npj Biofilms and Microbiomes |
| title | Population-level gut microbiome and its associations with environmental factors and metabolic disorders in Southwest China |
| title_full | Population-level gut microbiome and its associations with environmental factors and metabolic disorders in Southwest China |
| title_fullStr | Population-level gut microbiome and its associations with environmental factors and metabolic disorders in Southwest China |
| title_full_unstemmed | Population-level gut microbiome and its associations with environmental factors and metabolic disorders in Southwest China |
| title_short | Population-level gut microbiome and its associations with environmental factors and metabolic disorders in Southwest China |
| title_sort | population level gut microbiome and its associations with environmental factors and metabolic disorders in southwest china |
| url | https://doi.org/10.1038/s41522-025-00661-6 |
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