The Influence of Interleukin 17A and IL17F Polymorphisms on Chronic Periodontitis Disease in Brazilian Patients
A case-control study was conducted on patients with chronic periodontitis (CP) and healthy controls with the aim of evaluating possible association between interleukin 17A (IL17A) G197A (rs2275913) and IL17F T7488C (rs763780) polymorphisms and periodontitis. Genotypes were determined by PCR-RFLP met...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/147056 |
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| author | Joana Maira Valentini Zacarias Emília Ângela Sippert Patrícia Yumeko Tsuneto Jeane Eliete Laguila Visentainer Cléverson de Oliveira e Silva Ana Maria Sell |
| author_facet | Joana Maira Valentini Zacarias Emília Ângela Sippert Patrícia Yumeko Tsuneto Jeane Eliete Laguila Visentainer Cléverson de Oliveira e Silva Ana Maria Sell |
| author_sort | Joana Maira Valentini Zacarias |
| collection | DOAJ |
| description | A case-control study was conducted on patients with chronic periodontitis (CP) and healthy controls with the aim of evaluating possible association between interleukin 17A (IL17A) G197A (rs2275913) and IL17F T7488C (rs763780) polymorphisms and periodontitis. Genotypes were determined by PCR-RFLP method. Statistical analyses were conducted using the OpenEpi and SNPStas software to calculate Chi-square with Yates correction or Fisher’s exact tests, odds ratios (OR), and 95% confidence intervals (CIs). SNPStas software was used to calculate Hardy-Weinberg equilibrium. IL17A AA genotype was more frequent in patients with chronic periodontitis (CP) in the codominant and recessive models (P=0.09; OR = 2.53 and P=0.03; OR = 2.46, resp.), the females with CP (P=0.01, OR = 4.34), Caucasoid patients with CP (P=0.01, OR = 3.45), and nonsmoking Caucasian patients with CP (P=0.04, OR = 3.51). The IL17A A allele was also more frequent in Caucasians with CP (P=0.04, OR = 1.59). IL17F T7488C polymorphism was not associated with chronic periodontitis. In these patients from Southern Brazil, the IL17A rs2275913 polymorphisms, IL17A AA genotype, and the A allele were associated with a susceptibility to chronic periodontitis. |
| format | Article |
| id | doaj-art-dd84b0d3289f4f40accd51cc4c46acb5 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-dd84b0d3289f4f40accd51cc4c46acb52025-02-03T01:20:45ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/147056147056The Influence of Interleukin 17A and IL17F Polymorphisms on Chronic Periodontitis Disease in Brazilian PatientsJoana Maira Valentini Zacarias0Emília Ângela Sippert1Patrícia Yumeko Tsuneto2Jeane Eliete Laguila Visentainer3Cléverson de Oliveira e Silva4Ana Maria Sell5Post Graduation Program of Biosciences and Physiopathology, Biomedicine and Clinical Analysis Department, Maringá State University, 87020-900 Maringá, PR, BrazilPost Graduation Program of Biosciences and Physiopathology, Biomedicine and Clinical Analysis Department, Maringá State University, 87020-900 Maringá, PR, BrazilBiomedicine and Clinical Analysis Department, Maringá State University, 87020-900 Maringá, PR, BrazilBasic Health Sciences Department, Maringá State University, 87020-900 Maringá, PR, BrazilDentistry Department, Maringá State University, 87020-900 Maringá, PR, BrazilBasic Health Sciences Department, Maringá State University, 87020-900 Maringá, PR, BrazilA case-control study was conducted on patients with chronic periodontitis (CP) and healthy controls with the aim of evaluating possible association between interleukin 17A (IL17A) G197A (rs2275913) and IL17F T7488C (rs763780) polymorphisms and periodontitis. Genotypes were determined by PCR-RFLP method. Statistical analyses were conducted using the OpenEpi and SNPStas software to calculate Chi-square with Yates correction or Fisher’s exact tests, odds ratios (OR), and 95% confidence intervals (CIs). SNPStas software was used to calculate Hardy-Weinberg equilibrium. IL17A AA genotype was more frequent in patients with chronic periodontitis (CP) in the codominant and recessive models (P=0.09; OR = 2.53 and P=0.03; OR = 2.46, resp.), the females with CP (P=0.01, OR = 4.34), Caucasoid patients with CP (P=0.01, OR = 3.45), and nonsmoking Caucasian patients with CP (P=0.04, OR = 3.51). The IL17A A allele was also more frequent in Caucasians with CP (P=0.04, OR = 1.59). IL17F T7488C polymorphism was not associated with chronic periodontitis. In these patients from Southern Brazil, the IL17A rs2275913 polymorphisms, IL17A AA genotype, and the A allele were associated with a susceptibility to chronic periodontitis.http://dx.doi.org/10.1155/2015/147056 |
| spellingShingle | Joana Maira Valentini Zacarias Emília Ângela Sippert Patrícia Yumeko Tsuneto Jeane Eliete Laguila Visentainer Cléverson de Oliveira e Silva Ana Maria Sell The Influence of Interleukin 17A and IL17F Polymorphisms on Chronic Periodontitis Disease in Brazilian Patients Mediators of Inflammation |
| title | The Influence of Interleukin 17A and IL17F Polymorphisms on Chronic Periodontitis Disease in Brazilian Patients |
| title_full | The Influence of Interleukin 17A and IL17F Polymorphisms on Chronic Periodontitis Disease in Brazilian Patients |
| title_fullStr | The Influence of Interleukin 17A and IL17F Polymorphisms on Chronic Periodontitis Disease in Brazilian Patients |
| title_full_unstemmed | The Influence of Interleukin 17A and IL17F Polymorphisms on Chronic Periodontitis Disease in Brazilian Patients |
| title_short | The Influence of Interleukin 17A and IL17F Polymorphisms on Chronic Periodontitis Disease in Brazilian Patients |
| title_sort | influence of interleukin 17a and il17f polymorphisms on chronic periodontitis disease in brazilian patients |
| url | http://dx.doi.org/10.1155/2015/147056 |
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