Developmental trajectories of gyrification and sulcal morphometrics in children and adolescents at high familial risk for bipolar disorder or schizophrenia
Offspring of parents with severe mental illness are at increased risk of developing psychopathology. Identifying endophenotypic markers in high-familial-risk individuals can aid in early detection and inform development of prevention strategies. Using generalized additive mixed models, we compared a...
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| Format: | Article |
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Elsevier
2025-04-01
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| Series: | Developmental Cognitive Neuroscience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878929325000313 |
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| author | Simon R. Poortman Jakub Jamarík Louise ten Harmsen van der Beek Nikita Setiaman Manon H.J. Hillegers Marjolein E.A. Barendse Neeltje E.M. van Haren |
| author_facet | Simon R. Poortman Jakub Jamarík Louise ten Harmsen van der Beek Nikita Setiaman Manon H.J. Hillegers Marjolein E.A. Barendse Neeltje E.M. van Haren |
| author_sort | Simon R. Poortman |
| collection | DOAJ |
| description | Offspring of parents with severe mental illness are at increased risk of developing psychopathology. Identifying endophenotypic markers in high-familial-risk individuals can aid in early detection and inform development of prevention strategies. Using generalized additive mixed models, we compared age trajectories of gyrification index (GI) and sulcal morphometric measures (i.e., sulcal depth, length and width) between individuals at familial risk for bipolar disorder or schizophrenia and controls. 300 T1-weighted MRI scans were obtained of 187 individuals (53 % female, age range: 8–23 years) at familial risk for bipolar disorder (n = 80, n families=55) or schizophrenia (n = 53, n families=36) and controls (n = 54, n families=33). 113 individuals underwent two scans. Globally, GI, sulcal depth and sulcal length decreased significantly with age, and sulcal width increased significantly with age in a (near-)linear manner. There were no differences between groups in age trajectories or mean values of gyrification or any of the sulcal measures. These findings suggest that, on average, young individuals at familial risk for bipolar disorder or schizophrenia have preserved developmental patterns of gyrification and sulcal morphometrics during childhood and adolescence. |
| format | Article |
| id | doaj-art-dd8250d86d8a40529c81660b932dbce5 |
| institution | OA Journals |
| issn | 1878-9293 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Developmental Cognitive Neuroscience |
| spelling | doaj-art-dd8250d86d8a40529c81660b932dbce52025-08-20T02:04:33ZengElsevierDevelopmental Cognitive Neuroscience1878-92932025-04-017210153610.1016/j.dcn.2025.101536Developmental trajectories of gyrification and sulcal morphometrics in children and adolescents at high familial risk for bipolar disorder or schizophreniaSimon R. Poortman0Jakub Jamarík1Louise ten Harmsen van der Beek2Nikita Setiaman3Manon H.J. Hillegers4Marjolein E.A. Barendse5Neeltje E.M. van Haren6Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Sophia Children’s Hospital, Rotterdam, the Netherlands; Correspondence to: Erasmus University Medical Center - Sophia Children’s Hospital, Department of Child and Adolescent Psychiatry/Psychology, KP2, Wytemaweg 8, Rotterdam 3015 CN, the Netherlands.Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Sophia Children’s Hospital, Rotterdam, the Netherlands; Faculty of Medicine, Masaryk University, Brno, Czech RepublicDepartment of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Sophia Children’s Hospital, Rotterdam, the NetherlandsDepartment of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Sophia Children’s Hospital, Rotterdam, the Netherlands; Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht, the NetherlandsDepartment of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Sophia Children’s Hospital, Rotterdam, the Netherlands; Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht, the NetherlandsDepartment of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Sophia Children’s Hospital, Rotterdam, the NetherlandsDepartment of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Sophia Children’s Hospital, Rotterdam, the Netherlands; Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht, the NetherlandsOffspring of parents with severe mental illness are at increased risk of developing psychopathology. Identifying endophenotypic markers in high-familial-risk individuals can aid in early detection and inform development of prevention strategies. Using generalized additive mixed models, we compared age trajectories of gyrification index (GI) and sulcal morphometric measures (i.e., sulcal depth, length and width) between individuals at familial risk for bipolar disorder or schizophrenia and controls. 300 T1-weighted MRI scans were obtained of 187 individuals (53 % female, age range: 8–23 years) at familial risk for bipolar disorder (n = 80, n families=55) or schizophrenia (n = 53, n families=36) and controls (n = 54, n families=33). 113 individuals underwent two scans. Globally, GI, sulcal depth and sulcal length decreased significantly with age, and sulcal width increased significantly with age in a (near-)linear manner. There were no differences between groups in age trajectories or mean values of gyrification or any of the sulcal measures. These findings suggest that, on average, young individuals at familial risk for bipolar disorder or schizophrenia have preserved developmental patterns of gyrification and sulcal morphometrics during childhood and adolescence.http://www.sciencedirect.com/science/article/pii/S1878929325000313Bipolar disorderGyrificationHigh familial riskLongitudinalOffspringSchizophrenia |
| spellingShingle | Simon R. Poortman Jakub Jamarík Louise ten Harmsen van der Beek Nikita Setiaman Manon H.J. Hillegers Marjolein E.A. Barendse Neeltje E.M. van Haren Developmental trajectories of gyrification and sulcal morphometrics in children and adolescents at high familial risk for bipolar disorder or schizophrenia Developmental Cognitive Neuroscience Bipolar disorder Gyrification High familial risk Longitudinal Offspring Schizophrenia |
| title | Developmental trajectories of gyrification and sulcal morphometrics in children and adolescents at high familial risk for bipolar disorder or schizophrenia |
| title_full | Developmental trajectories of gyrification and sulcal morphometrics in children and adolescents at high familial risk for bipolar disorder or schizophrenia |
| title_fullStr | Developmental trajectories of gyrification and sulcal morphometrics in children and adolescents at high familial risk for bipolar disorder or schizophrenia |
| title_full_unstemmed | Developmental trajectories of gyrification and sulcal morphometrics in children and adolescents at high familial risk for bipolar disorder or schizophrenia |
| title_short | Developmental trajectories of gyrification and sulcal morphometrics in children and adolescents at high familial risk for bipolar disorder or schizophrenia |
| title_sort | developmental trajectories of gyrification and sulcal morphometrics in children and adolescents at high familial risk for bipolar disorder or schizophrenia |
| topic | Bipolar disorder Gyrification High familial risk Longitudinal Offspring Schizophrenia |
| url | http://www.sciencedirect.com/science/article/pii/S1878929325000313 |
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