A covalent creatine kinase inhibitor ablates glioblastoma migration and sensitizes tumors to oxidative stress

A covalent creatine kinase inhibitor ablates glioblastoma migration and sensitizes tumors to oxidative stress

Abstract Glioblastoma is a Grade 4 primary brain tumor defined by therapy resistance, diffuse infiltration, and near-uniform lethality. The underlying mechanisms are unknown, and no treatment has been curative. Using a recently developed creatine kinase inhibitor (CKi), we explored the role of this...

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Bibliographic Details
Main Authors: Joshua L. Katz, Yuheng Geng, Leah K. Billingham, Nishanth S. Sadagopan, Susan L. DeLay, Jay Subbiah, Tzu-yi Chia, Graysen McManus, Chao Wei, Hanxiang Wang, Hanchen Lin, Caylee Silvers, Lauren K. Boland, Si Wang, Hanxiao Wan, David Hou, Gustavo Ignacio Vázquez-Cervantes, Tarlan Arjmandi, Zainab H. Shaikh, Peng Zhang, Atique U. Ahmed, Deanna M. Tiek, Catalina Lee-Chang, Edward T. Chouchani, Jason Miska
Format: Article
Language:English
Published: Nature Portfolio 2024-09-01
Series:Scientific Reports
Subjects:
Brain tumor
Tumor metabolism
Oxidative stress
Cell migration
Enzyme inhibitor
Online Access:https://doi.org/10.1038/s41598-024-73051-1
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