Efficacy of a metalloproteinase inhibitor in spinal cord injured dogs.

Efficacy of a metalloproteinase inhibitor in spinal cord injured dogs.

Matrix metalloproteinase-9 is elevated within the acutely injured murine spinal cord and blockade of this early proteolytic activity with GM6001, a broad-spectrum matrix metalloproteinase inhibitor, results in improved recovery after spinal cord injury. As matrix metalloproteinase-9 is likewise acut...

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Bibliographic Details
Main Authors: Jonathan M Levine, Noah D Cohen, Michael Heller, Virginia R Fajt, Gwendolyn J Levine, Sharon C Kerwin, Alpa A Trivedi, Thomas M Fandel, Zena Werb, Augusta Modestino, Linda J Noble-Haeusslein
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0096408&type=printable
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