Innovative applications and future perspectives of chromatography-mass spectrometry in drug research
Chromatography coupled with mass spectrometry (MS) has emerged as a cornerstone analytical technique in drug research. Over the years, advancements in chromatography-MS have significantly enhanced its capabilities, leading to improved sensitivity, specificity, and throughput. This review explores th...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1529468/full |
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| author | Hong Cai Xue Xing Ying Su Chunhui Yang |
| author_facet | Hong Cai Xue Xing Ying Su Chunhui Yang |
| author_sort | Hong Cai |
| collection | DOAJ |
| description | Chromatography coupled with mass spectrometry (MS) has emerged as a cornerstone analytical technique in drug research. Over the years, advancements in chromatography-MS have significantly enhanced its capabilities, leading to improved sensitivity, specificity, and throughput. This review explores the innovative applications of chromatography-MS in drug research, particularly focusing on its role in drug absorption, distribution, metabolism, excretion (ADME), toxicity evaluation, and personalized medicine. It also addresses the future perspectives of this powerful technique, including challenges and potential solutions, and highlights how emerging trends such as high spatial resolution imaging and multimodal integration could revolutionize drug discovery and development. Through these innovations, chromatography-MS promises to contribute substantially to the development of more effective, safer, and personalized therapeutic interventions. |
| format | Article |
| id | doaj-art-dd70a72315bf4df8bd4d137aff646c0b |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-dd70a72315bf4df8bd4d137aff646c0b2025-08-20T03:40:21ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-03-011610.3389/fphar.2025.15294681529468Innovative applications and future perspectives of chromatography-mass spectrometry in drug researchHong CaiXue XingYing SuChunhui YangChromatography coupled with mass spectrometry (MS) has emerged as a cornerstone analytical technique in drug research. Over the years, advancements in chromatography-MS have significantly enhanced its capabilities, leading to improved sensitivity, specificity, and throughput. This review explores the innovative applications of chromatography-MS in drug research, particularly focusing on its role in drug absorption, distribution, metabolism, excretion (ADME), toxicity evaluation, and personalized medicine. It also addresses the future perspectives of this powerful technique, including challenges and potential solutions, and highlights how emerging trends such as high spatial resolution imaging and multimodal integration could revolutionize drug discovery and development. Through these innovations, chromatography-MS promises to contribute substantially to the development of more effective, safer, and personalized therapeutic interventions.https://www.frontiersin.org/articles/10.3389/fphar.2025.1529468/fullchromatography-mass spectrometrydrug researchpharmacokineticsdrug metabolismpersonalized medicine |
| spellingShingle | Hong Cai Xue Xing Ying Su Chunhui Yang Innovative applications and future perspectives of chromatography-mass spectrometry in drug research Frontiers in Pharmacology chromatography-mass spectrometry drug research pharmacokinetics drug metabolism personalized medicine |
| title | Innovative applications and future perspectives of chromatography-mass spectrometry in drug research |
| title_full | Innovative applications and future perspectives of chromatography-mass spectrometry in drug research |
| title_fullStr | Innovative applications and future perspectives of chromatography-mass spectrometry in drug research |
| title_full_unstemmed | Innovative applications and future perspectives of chromatography-mass spectrometry in drug research |
| title_short | Innovative applications and future perspectives of chromatography-mass spectrometry in drug research |
| title_sort | innovative applications and future perspectives of chromatography mass spectrometry in drug research |
| topic | chromatography-mass spectrometry drug research pharmacokinetics drug metabolism personalized medicine |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1529468/full |
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