Case report: a rare mediastinal neuroblastoma in an adult associated with syndrome of inappropriate secretion of antidiuretic hormone (SIADH)
Neuroblastoma is an embryonic cancer arising from neural crest stem cell and almost exclusively a pediatric neoplasm. In adults, neuroblastoma is rare and presents worse prognosis compared to children. The most common presentation of this neoplasia is a painless abdominal mass. Other signs and sympt...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Thieme Revinter Publicações Ltda.
2023-08-01
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| Series: | Brazilian Journal of Oncology |
| Subjects: | |
| Online Access: | https://www.brazilianjournalofoncology.com.br/details/253/en-US/case-report--a-rare-mediastinal-neuroblastoma-in-an-adult-associated-with-syndrome-of-inappropriate-secretion-of-antidiuretic-hormone--siadh- |
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| Summary: | Neuroblastoma is an embryonic cancer arising from neural crest stem cell and almost exclusively a pediatric neoplasm. In adults, neuroblastoma is rare and presents worse prognosis compared to children. The most common presentation of this neoplasia is a painless abdominal mass. Other signs and symptoms can be related to mass effect from the primary tumor or as a result of metastatic disease, or paraneoplastic syndromes. There are no well-established treatment guidelines for adults with neuroblastoma. In general, the principle of treatment is determined by risk assessment system, using a multimodal treatment (surgery, chemotherapy, and radiotherapy) based on treatment protocols for this neoplasm in children. This case report refers to the diagnosis of neuroblastoma in mediastinum in a 52-year-old woman with locally advanced disease and not able to be removed to diagnosis, accompanied by hyponatremia as paraneoplastic syndrome, which presented a good response to the treatment established. |
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| ISSN: | 2526-8732 |