Low Serum Level of Vitamin D is Associated with Uterine Leiomyoma in the Chinese Population
Background: The goal of this work was to compare the serum vitamin D level in women with uterine leiomyoma to that of controls, and to examine its association with the etiopathogenesis of this disease. Methods: This case-control study included 110 premenopausal women referred to a university hospita...
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IMR Press
2023-03-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
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| Online Access: | https://www.imrpress.com/journal/CEOG/50/3/10.31083/j.ceog5003055 |
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| author | Xinping Chen Fen Yang Zhiqiang Shen Xuxiu Tang Jiali Yu Fujun Liu |
| author_facet | Xinping Chen Fen Yang Zhiqiang Shen Xuxiu Tang Jiali Yu Fujun Liu |
| author_sort | Xinping Chen |
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| description | Background: The goal of this work was to compare the serum vitamin D level in women with uterine leiomyoma to that of controls, and to examine its association with the etiopathogenesis of this disease. Methods: This case-control study included 110 premenopausal women referred to a university hospital from January 2020 to December 2020. The study group consisted of 55 cases who underwent surgery for uterine fibroids, while the control group was comprised of 55 subjects without uterine fibroids. The number and volume of existing fibroids in each subject was assessed by transvaginal ultrasonography. Serum vitamin D status was determined by radioimmunoassay for 25-hydroxyvitamin D. Results: Average serum 25-hydroxyvitamin D levels in patients with uterine fibroids (20.52 ± 6.17 ng/mL) were significantly lower than in controls (24.18 ± 6.88 ng/mL; p = 0.004). Deficiency in 25-hydroxyvitamin D (i.e., <20 ng/mL) was more frequent in women with uterine fibroids (28/55, 50.91%) compared to controls (13/55, 23.64%; p = 0.001). A trend for negative correlation was found between serum 25-hydroxyvitamin D levels and total uterine fibroid volume (r = –0.18) in the study group (p = 0.20). No significant associations were found between serum 25-hydroxyvitamin D level and the number of fibroids (p = 0.38) or their location (p = 0.89). Conclusions: The serum vitamin D concentration is lower in Chinese women with uterine leiomyomas compared to controls. Vitamin D deficiency could therefore be a risk factor for uterine leiomyoma in the Chinese population. |
| format | Article |
| id | doaj-art-dd65e84f49474a7482d179b0c2fa4d30 |
| institution | OA Journals |
| issn | 0390-6663 |
| language | English |
| publishDate | 2023-03-01 |
| publisher | IMR Press |
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| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj-art-dd65e84f49474a7482d179b0c2fa4d302025-08-20T02:21:30ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632023-03-015035510.31083/j.ceog5003055S0390-6663(23)02021-3Low Serum Level of Vitamin D is Associated with Uterine Leiomyoma in the Chinese PopulationXinping Chen0Fen Yang1Zhiqiang Shen2Xuxiu Tang3Jiali Yu4Fujun Liu5Department of Gynecology and Obstetrics, The First Affiliated Hospital of Nanchang University, 330006 Nanchang, Jiangxi, ChinaDepartment of Stomatology, The First Affiliated Hospital of Nanchang University, 330006 Nanchang, Jiangxi, ChinaDepartment of Gynecology and Obstetrics, The First Affiliated Hospital of Nanchang University, 330006 Nanchang, Jiangxi, ChinaDepartment of Gynecology and Obstetrics, The First Affiliated Hospital of Nanchang University, 330006 Nanchang, Jiangxi, ChinaDepartment of Gynecology and Obstetrics, The First Affiliated Hospital of Nanchang University, 330006 Nanchang, Jiangxi, ChinaDepartment of Gynecology and Obstetrics, The First Affiliated Hospital of Nanchang University, 330006 Nanchang, Jiangxi, ChinaBackground: The goal of this work was to compare the serum vitamin D level in women with uterine leiomyoma to that of controls, and to examine its association with the etiopathogenesis of this disease. Methods: This case-control study included 110 premenopausal women referred to a university hospital from January 2020 to December 2020. The study group consisted of 55 cases who underwent surgery for uterine fibroids, while the control group was comprised of 55 subjects without uterine fibroids. The number and volume of existing fibroids in each subject was assessed by transvaginal ultrasonography. Serum vitamin D status was determined by radioimmunoassay for 25-hydroxyvitamin D. Results: Average serum 25-hydroxyvitamin D levels in patients with uterine fibroids (20.52 ± 6.17 ng/mL) were significantly lower than in controls (24.18 ± 6.88 ng/mL; p = 0.004). Deficiency in 25-hydroxyvitamin D (i.e., <20 ng/mL) was more frequent in women with uterine fibroids (28/55, 50.91%) compared to controls (13/55, 23.64%; p = 0.001). A trend for negative correlation was found between serum 25-hydroxyvitamin D levels and total uterine fibroid volume (r = –0.18) in the study group (p = 0.20). No significant associations were found between serum 25-hydroxyvitamin D level and the number of fibroids (p = 0.38) or their location (p = 0.89). Conclusions: The serum vitamin D concentration is lower in Chinese women with uterine leiomyomas compared to controls. Vitamin D deficiency could therefore be a risk factor for uterine leiomyoma in the Chinese population.https://www.imrpress.com/journal/CEOG/50/3/10.31083/j.ceog5003055serum 25-hydroxyvitamin d leveluterine leiomyomasoccurrencechinese population |
| spellingShingle | Xinping Chen Fen Yang Zhiqiang Shen Xuxiu Tang Jiali Yu Fujun Liu Low Serum Level of Vitamin D is Associated with Uterine Leiomyoma in the Chinese Population Clinical and Experimental Obstetrics & Gynecology serum 25-hydroxyvitamin d level uterine leiomyomas occurrence chinese population |
| title | Low Serum Level of Vitamin D is Associated with Uterine Leiomyoma in the Chinese Population |
| title_full | Low Serum Level of Vitamin D is Associated with Uterine Leiomyoma in the Chinese Population |
| title_fullStr | Low Serum Level of Vitamin D is Associated with Uterine Leiomyoma in the Chinese Population |
| title_full_unstemmed | Low Serum Level of Vitamin D is Associated with Uterine Leiomyoma in the Chinese Population |
| title_short | Low Serum Level of Vitamin D is Associated with Uterine Leiomyoma in the Chinese Population |
| title_sort | low serum level of vitamin d is associated with uterine leiomyoma in the chinese population |
| topic | serum 25-hydroxyvitamin d level uterine leiomyomas occurrence chinese population |
| url | https://www.imrpress.com/journal/CEOG/50/3/10.31083/j.ceog5003055 |
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