Bioinspired synthetic peptide-based biomaterials regenerate bone through biomimicking of extracellular matrix
There have been remarkable advancements in regenerative medicine for bone regeneration, tackling the worldwide health concern of tissue loss. Tissue engineering uses the body’s natural capabilities and applies biomaterials and bioactive molecules to replace damaged or lost tissues and restore their...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2024-12-01
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| Series: | Journal of Tissue Engineering |
| Online Access: | https://doi.org/10.1177/20417314241303818 |
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| author | Sareh Azadi Mohammad Ali Yazdanpanah Ali Afshari Niloofar Alahdad Solmaz Chegeni Abdolhamid Angaji Seyed Mahdi Rezayat Shima Tavakol |
| author_facet | Sareh Azadi Mohammad Ali Yazdanpanah Ali Afshari Niloofar Alahdad Solmaz Chegeni Abdolhamid Angaji Seyed Mahdi Rezayat Shima Tavakol |
| author_sort | Sareh Azadi |
| collection | DOAJ |
| description | There have been remarkable advancements in regenerative medicine for bone regeneration, tackling the worldwide health concern of tissue loss. Tissue engineering uses the body’s natural capabilities and applies biomaterials and bioactive molecules to replace damaged or lost tissues and restore their functionality. While synthetic ceramics have overcome some challenges associated with allografts and xenografts, they still need essential growth factors and biomolecules. Combining ceramics and bioactive molecules, such as peptides derived from biological motifs of vital proteins, is the most effective approach to achieve optimal bone regeneration. These bioactive peptides induce various cellular processes and modify scaffold properties by mimicking the function of natural osteogenic, angiogenic and antibacterial biomolecules. The present review aims to consolidate the latest and most pertinent information on the advancements in bioactive peptides, including angiogenic, osteogenic, antimicrobial, and self-assembling peptide nanofibers for bone tissue regeneration, elucidating their biological effects and potential clinical implications. |
| format | Article |
| id | doaj-art-dd643cfb024f497c8628ba49d5369ac3 |
| institution | DOAJ |
| issn | 2041-7314 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Tissue Engineering |
| spelling | doaj-art-dd643cfb024f497c8628ba49d5369ac32025-08-20T02:50:22ZengSAGE PublishingJournal of Tissue Engineering2041-73142024-12-011510.1177/20417314241303818Bioinspired synthetic peptide-based biomaterials regenerate bone through biomimicking of extracellular matrixSareh Azadi0Mohammad Ali Yazdanpanah1Ali Afshari2Niloofar Alahdad3Solmaz Chegeni4Abdolhamid Angaji5Seyed Mahdi Rezayat6Shima Tavakol7Department of Medical Biotechnology, Iran University of Medical Sciences, Tehran, IranDepartment of Cell and Molecular Biology, Faculty of Biological Science, Kharazmi University, Tehran, IranDepartment of Cell and Molecular Biology, Faculty of Biological Science, Kharazmi University, Tehran, IranDepartment of Cell and Molecular Biology, Faculty of Biological Science, Kharazmi University, Tehran, IranCellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, IranDepartment of Medical Biotechnology, Iran University of Medical Sciences, Tehran, IranDepartment of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, IranDepartment of Research and Development, Tavakol Biomimetic Technologies Company, Tehran, IranThere have been remarkable advancements in regenerative medicine for bone regeneration, tackling the worldwide health concern of tissue loss. Tissue engineering uses the body’s natural capabilities and applies biomaterials and bioactive molecules to replace damaged or lost tissues and restore their functionality. While synthetic ceramics have overcome some challenges associated with allografts and xenografts, they still need essential growth factors and biomolecules. Combining ceramics and bioactive molecules, such as peptides derived from biological motifs of vital proteins, is the most effective approach to achieve optimal bone regeneration. These bioactive peptides induce various cellular processes and modify scaffold properties by mimicking the function of natural osteogenic, angiogenic and antibacterial biomolecules. The present review aims to consolidate the latest and most pertinent information on the advancements in bioactive peptides, including angiogenic, osteogenic, antimicrobial, and self-assembling peptide nanofibers for bone tissue regeneration, elucidating their biological effects and potential clinical implications.https://doi.org/10.1177/20417314241303818 |
| spellingShingle | Sareh Azadi Mohammad Ali Yazdanpanah Ali Afshari Niloofar Alahdad Solmaz Chegeni Abdolhamid Angaji Seyed Mahdi Rezayat Shima Tavakol Bioinspired synthetic peptide-based biomaterials regenerate bone through biomimicking of extracellular matrix Journal of Tissue Engineering |
| title | Bioinspired synthetic peptide-based biomaterials regenerate bone through biomimicking of extracellular matrix |
| title_full | Bioinspired synthetic peptide-based biomaterials regenerate bone through biomimicking of extracellular matrix |
| title_fullStr | Bioinspired synthetic peptide-based biomaterials regenerate bone through biomimicking of extracellular matrix |
| title_full_unstemmed | Bioinspired synthetic peptide-based biomaterials regenerate bone through biomimicking of extracellular matrix |
| title_short | Bioinspired synthetic peptide-based biomaterials regenerate bone through biomimicking of extracellular matrix |
| title_sort | bioinspired synthetic peptide based biomaterials regenerate bone through biomimicking of extracellular matrix |
| url | https://doi.org/10.1177/20417314241303818 |
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