Targeting EphA2 suppresses the proliferation, migration and invasion of endometriosis via the AMPK signaling pathway
Endometriosis is a benign disease with similar characteristics to tumors. Recent studies have found that the erythropoietin-producing hepatoma receptor A2 (EphA2) has the dual effect of promoting tumor and inhibiting tumor. The objective of this study was to explore the specific regulatory mechanism...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2025-06-01
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| Series: | European Journal of Histochemistry |
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| Online Access: | https://www.ejh.it/ejh/article/view/4168 |
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| author | Chaoyi Yang Shujun Wang Mengru Li Xiangli Pang Aili Tan |
| author_facet | Chaoyi Yang Shujun Wang Mengru Li Xiangli Pang Aili Tan |
| author_sort | Chaoyi Yang |
| collection | DOAJ |
| description | Endometriosis is a benign disease with similar characteristics to tumors. Recent studies have found that the erythropoietin-producing hepatoma receptor A2 (EphA2) has the dual effect of promoting tumor and inhibiting tumor. The objective of this study was to explore the specific regulatory mechanism of EphA2 in endometriosis. The expression level of Eph protein family in endometriosis was analyzed by bioinformatics method. At the clinical level, qPCR, Western blot and immunohistochemistry were used to verify the correlation between increased EphA2 levels and endometriosis. The effects of blocking EphA2 on cell migration, invasion, proliferation and apoptosis of primary eutopic endometriotic stromal cells were explored in vitro. Our study indicated that EphA2 expression was elevated in endometriosis patients, and blocking EphA2 in vitro inhibited cell proliferation, migration and invasion through AMPK signaling pathway. Targeting EphA2 can inhibit the progression of endometriosis through the AMPK signaling pathway.
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| format | Article |
| id | doaj-art-dd613600042447e280cff2c94ab6ff95 |
| institution | DOAJ |
| issn | 1121-760X 2038-8306 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | European Journal of Histochemistry |
| spelling | doaj-art-dd613600042447e280cff2c94ab6ff952025-08-20T03:11:39ZengPAGEPress PublicationsEuropean Journal of Histochemistry1121-760X2038-83062025-06-0169310.4081/ejh.2025.4168Targeting EphA2 suppresses the proliferation, migration and invasion of endometriosis via the AMPK signaling pathwayChaoyi Yang0Shujun Wang1Mengru Li2Xiangli Pang3Aili Tan4Department of Obstetrics and Gynecology, Renmin Hospital of Wuhan University, Wuhan, HubeiDepartment of Obstetrics and Gynecology, Renmin Hospital of Wuhan University, Wuhan, HubeiDepartment of Obstetrics and Gynecology, Renmin Hospital of Wuhan University, Wuhan, HubeiDepartment of Obstetrics and Gynecology, Renmin Hospital of Wuhan University, Wuhan, HubeiDepartment of Obstetrics and Gynecology, Renmin Hospital of Wuhan University, Wuhan, HubeiEndometriosis is a benign disease with similar characteristics to tumors. Recent studies have found that the erythropoietin-producing hepatoma receptor A2 (EphA2) has the dual effect of promoting tumor and inhibiting tumor. The objective of this study was to explore the specific regulatory mechanism of EphA2 in endometriosis. The expression level of Eph protein family in endometriosis was analyzed by bioinformatics method. At the clinical level, qPCR, Western blot and immunohistochemistry were used to verify the correlation between increased EphA2 levels and endometriosis. The effects of blocking EphA2 on cell migration, invasion, proliferation and apoptosis of primary eutopic endometriotic stromal cells were explored in vitro. Our study indicated that EphA2 expression was elevated in endometriosis patients, and blocking EphA2 in vitro inhibited cell proliferation, migration and invasion through AMPK signaling pathway. Targeting EphA2 can inhibit the progression of endometriosis through the AMPK signaling pathway. https://www.ejh.it/ejh/article/view/4168EndometriosisEphA2AMPK signaling pathwayALW-II-41-27 |
| spellingShingle | Chaoyi Yang Shujun Wang Mengru Li Xiangli Pang Aili Tan Targeting EphA2 suppresses the proliferation, migration and invasion of endometriosis via the AMPK signaling pathway European Journal of Histochemistry Endometriosis EphA2 AMPK signaling pathway ALW-II-41-27 |
| title | Targeting EphA2 suppresses the proliferation, migration and invasion of endometriosis via the AMPK signaling pathway |
| title_full | Targeting EphA2 suppresses the proliferation, migration and invasion of endometriosis via the AMPK signaling pathway |
| title_fullStr | Targeting EphA2 suppresses the proliferation, migration and invasion of endometriosis via the AMPK signaling pathway |
| title_full_unstemmed | Targeting EphA2 suppresses the proliferation, migration and invasion of endometriosis via the AMPK signaling pathway |
| title_short | Targeting EphA2 suppresses the proliferation, migration and invasion of endometriosis via the AMPK signaling pathway |
| title_sort | targeting epha2 suppresses the proliferation migration and invasion of endometriosis via the ampk signaling pathway |
| topic | Endometriosis EphA2 AMPK signaling pathway ALW-II-41-27 |
| url | https://www.ejh.it/ejh/article/view/4168 |
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