Acupuncture treatment for Hashimoto's thyroiditis: An exploratory randomized controlled trial
Background: Hashimoto's thyroiditis (HT) has a high incidence rate and unresolved clinical symptoms. Although Hand Yangming Meridian Penetrating Acupuncture has been used to treat thyroid diseases in China, there is no randomized controlled trial (RCT) on HT. Methods: This exploratory RCT aims...
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Elsevier
2024-03-01
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| Series: | Integrative Medicine Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213422024000039 |
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| author | Shanze Wang Chao Yang Weimei Zeng Hongfang Tian Shihao Du Jiping Zhao |
| author_facet | Shanze Wang Chao Yang Weimei Zeng Hongfang Tian Shihao Du Jiping Zhao |
| author_sort | Shanze Wang |
| collection | DOAJ |
| description | Background: Hashimoto's thyroiditis (HT) has a high incidence rate and unresolved clinical symptoms. Although Hand Yangming Meridian Penetrating Acupuncture has been used to treat thyroid diseases in China, there is no randomized controlled trial (RCT) on HT. Methods: This exploratory RCT aims to preliminarily evaluate the efficacy, safety, and feasibility of Hand Yangming Meridian Penetrating Acupuncture in the treatment of HT. Included subjects were randomly assigned to the acupuncture group and the waiting treatment group at a ratio of 1:1. Subjects in the acupuncture group received 16 weeks of acupuncture treatment, followed by a 16-week follow-up observation phase. Subjects in the waiting group received thyroxine supplementation for 16 weeks, followed by 16 weeks of compensation treatment. Serum thyroid peroxidase antibody (TPOab) and thyroglobulin antibody (TGab) levels were the main indicators, and Thyroid-Related Patient-Reported Outcome short form (ThyPRO-39), MOS Item Short Form Health Survey (SF-36), and Hospital Anxiety and Depression Scale (HADS) scores were also recorded. Results: In total, 58 subjects were included. After 16 weeks of treatment, there was no statistical difference in the changes in TPOab levels between the two groups, but the TGab level in the acupuncture group was significantly lower than in the waiting group (difference: −141.97 [95 % CI: −222.4 to −61.5], P = 0.011). Moreover, the total ThyPRO-39 and SF-36 scores were statistically different between the two groups (PThyPRO-39 < 0.001, PSF-36 = 0.005). There was no statistical difference in HADS between the two groups. Conclusions: Hand Yangming Meridian Penetrating Acupuncture may be safe and feasible for HT hypothyroidism to improve symptoms and reduce TGab levels. Trial registration: This trial was registered at Acupuncture-Moxibustion Clinical Trial Registry: AMCTR-IOR-19000308 (ChiCTR1900026830, https://www.chictr.org.cn/searchprojEN.html). |
| format | Article |
| id | doaj-art-dd5f78aa41524f0f9e1079c15c2d00db |
| institution | DOAJ |
| issn | 2213-4220 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Integrative Medicine Research |
| spelling | doaj-art-dd5f78aa41524f0f9e1079c15c2d00db2025-08-20T03:04:44ZengElsevierIntegrative Medicine Research2213-42202024-03-0113110102310.1016/j.imr.2024.101023Acupuncture treatment for Hashimoto's thyroiditis: An exploratory randomized controlled trialShanze Wang0Chao Yang1Weimei Zeng2Hongfang Tian3Shihao Du4Jiping Zhao5The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, ChinaDongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, ChinaDongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, ChinaThe Third Affiliated Hospital of Zhejiang University of Chinese Medicine, Hangzhou, ChinaInstitute of Acupuncture and Moxibustion, Chinese Academy of Chinese Medicine, Beijing, ChinaDongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, China; Corresponding author at: Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, 100700, China.Background: Hashimoto's thyroiditis (HT) has a high incidence rate and unresolved clinical symptoms. Although Hand Yangming Meridian Penetrating Acupuncture has been used to treat thyroid diseases in China, there is no randomized controlled trial (RCT) on HT. Methods: This exploratory RCT aims to preliminarily evaluate the efficacy, safety, and feasibility of Hand Yangming Meridian Penetrating Acupuncture in the treatment of HT. Included subjects were randomly assigned to the acupuncture group and the waiting treatment group at a ratio of 1:1. Subjects in the acupuncture group received 16 weeks of acupuncture treatment, followed by a 16-week follow-up observation phase. Subjects in the waiting group received thyroxine supplementation for 16 weeks, followed by 16 weeks of compensation treatment. Serum thyroid peroxidase antibody (TPOab) and thyroglobulin antibody (TGab) levels were the main indicators, and Thyroid-Related Patient-Reported Outcome short form (ThyPRO-39), MOS Item Short Form Health Survey (SF-36), and Hospital Anxiety and Depression Scale (HADS) scores were also recorded. Results: In total, 58 subjects were included. After 16 weeks of treatment, there was no statistical difference in the changes in TPOab levels between the two groups, but the TGab level in the acupuncture group was significantly lower than in the waiting group (difference: −141.97 [95 % CI: −222.4 to −61.5], P = 0.011). Moreover, the total ThyPRO-39 and SF-36 scores were statistically different between the two groups (PThyPRO-39 < 0.001, PSF-36 = 0.005). There was no statistical difference in HADS between the two groups. Conclusions: Hand Yangming Meridian Penetrating Acupuncture may be safe and feasible for HT hypothyroidism to improve symptoms and reduce TGab levels. Trial registration: This trial was registered at Acupuncture-Moxibustion Clinical Trial Registry: AMCTR-IOR-19000308 (ChiCTR1900026830, https://www.chictr.org.cn/searchprojEN.html).http://www.sciencedirect.com/science/article/pii/S2213422024000039AcupunctureHashimoto's thyroiditisRCTSerum thyroglobulin antibodyQuality of life |
| spellingShingle | Shanze Wang Chao Yang Weimei Zeng Hongfang Tian Shihao Du Jiping Zhao Acupuncture treatment for Hashimoto's thyroiditis: An exploratory randomized controlled trial Integrative Medicine Research Acupuncture Hashimoto's thyroiditis RCT Serum thyroglobulin antibody Quality of life |
| title | Acupuncture treatment for Hashimoto's thyroiditis: An exploratory randomized controlled trial |
| title_full | Acupuncture treatment for Hashimoto's thyroiditis: An exploratory randomized controlled trial |
| title_fullStr | Acupuncture treatment for Hashimoto's thyroiditis: An exploratory randomized controlled trial |
| title_full_unstemmed | Acupuncture treatment for Hashimoto's thyroiditis: An exploratory randomized controlled trial |
| title_short | Acupuncture treatment for Hashimoto's thyroiditis: An exploratory randomized controlled trial |
| title_sort | acupuncture treatment for hashimoto s thyroiditis an exploratory randomized controlled trial |
| topic | Acupuncture Hashimoto's thyroiditis RCT Serum thyroglobulin antibody Quality of life |
| url | http://www.sciencedirect.com/science/article/pii/S2213422024000039 |
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