Proceedings of the 12th annual deep brain stimulation think tank: cutting edge technology meets novel applications

The Deep Brain Stimulation (DBS) Think Tank XII was held on August 21st to 23rd. This year we showcased groundbreaking advancements in neuromodulation technology, focusing heavily on the novel uses of existing technology as well as next-generation technology. Our keynote speaker shared the vision of...

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Main Authors: Alfonso Enrique Martinez-Nunez, Christopher J. Rozell, Simon Little, Huiling Tan, Stephen L. Schmidt, Warren M. Grill, Miroslav Pajic, Dennis A. Turner, Coralie de Hemptinne, Andre Machado, Nicholas D. Schiff, Abbey S. Holt-Becker, Robert S. Raike, Mahsa Malekmohammadi, Yagna J. Pathak, Lyndahl Himes, David Greene, Lothar Krinke, Mattia Arlotti, Lorenzo Rossi, Jacob Robinson, Bahne H. Bahners, Vladimir Litvak, Luka Milosevic, Saadi Ghatan, Frederic L. W. V. J. Schaper, Michael D. Fox, Nicholas M. Gregg, Cynthia Kubu, James J. Jordano, Nicola G. Cascella, YoungHoon Nho, Casey H. Halpern, Helen S. Mayberg, Ki Sueng Choi, Haneul Song, Jungho Cha, Sankaraleengam Alagapan, Nico U. F. Dosenbach, Evan M. Gordon, Jianxun Ren, Hesheng Liu, Lorraine V. Kalia, Sarah-Anna Hescham, Dorian M. Kusyk, Adolfo Ramirez-Zamora, Kelly D. Foote, Michael S. Okun, Joshua K. Wong
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Human Neuroscience
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Online Access:https://www.frontiersin.org/articles/10.3389/fnhum.2025.1544994/full
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author Alfonso Enrique Martinez-Nunez
Christopher J. Rozell
Simon Little
Huiling Tan
Stephen L. Schmidt
Warren M. Grill
Warren M. Grill
Miroslav Pajic
Dennis A. Turner
Dennis A. Turner
Dennis A. Turner
Coralie de Hemptinne
Andre Machado
Andre Machado
Nicholas D. Schiff
Abbey S. Holt-Becker
Robert S. Raike
Mahsa Malekmohammadi
Mahsa Malekmohammadi
Yagna J. Pathak
Lyndahl Himes
David Greene
Lothar Krinke
Lothar Krinke
Mattia Arlotti
Lorenzo Rossi
Jacob Robinson
Jacob Robinson
Bahne H. Bahners
Bahne H. Bahners
Bahne H. Bahners
Vladimir Litvak
Luka Milosevic
Luka Milosevic
Saadi Ghatan
Saadi Ghatan
Frederic L. W. V. J. Schaper
Michael D. Fox
Nicholas M. Gregg
Cynthia Kubu
James J. Jordano
James J. Jordano
James J. Jordano
Nicola G. Cascella
YoungHoon Nho
Casey H. Halpern
Casey H. Halpern
Helen S. Mayberg
Helen S. Mayberg
Helen S. Mayberg
Ki Sueng Choi
Ki Sueng Choi
Haneul Song
Jungho Cha
Sankaraleengam Alagapan
Nico U. F. Dosenbach
Nico U. F. Dosenbach
Nico U. F. Dosenbach
Nico U. F. Dosenbach
Nico U. F. Dosenbach
Nico U. F. Dosenbach
Evan M. Gordon
Jianxun Ren
Hesheng Liu
Hesheng Liu
Lorraine V. Kalia
Lorraine V. Kalia
Sarah-Anna Hescham
Sarah-Anna Hescham
Sarah-Anna Hescham
Dorian M. Kusyk
Adolfo Ramirez-Zamora
Kelly D. Foote
Michael S. Okun
Joshua K. Wong
author_facet Alfonso Enrique Martinez-Nunez
Christopher J. Rozell
Simon Little
Huiling Tan
Stephen L. Schmidt
Warren M. Grill
Warren M. Grill
Miroslav Pajic
Dennis A. Turner
Dennis A. Turner
Dennis A. Turner
Coralie de Hemptinne
Andre Machado
Andre Machado
Nicholas D. Schiff
Abbey S. Holt-Becker
Robert S. Raike
Mahsa Malekmohammadi
Mahsa Malekmohammadi
Yagna J. Pathak
Lyndahl Himes
David Greene
Lothar Krinke
Lothar Krinke
Mattia Arlotti
Lorenzo Rossi
Jacob Robinson
Jacob Robinson
Bahne H. Bahners
Bahne H. Bahners
Bahne H. Bahners
Vladimir Litvak
Luka Milosevic
Luka Milosevic
Saadi Ghatan
Saadi Ghatan
Frederic L. W. V. J. Schaper
Michael D. Fox
Nicholas M. Gregg
Cynthia Kubu
James J. Jordano
James J. Jordano
James J. Jordano
Nicola G. Cascella
YoungHoon Nho
Casey H. Halpern
Casey H. Halpern
Helen S. Mayberg
Helen S. Mayberg
Helen S. Mayberg
Ki Sueng Choi
Ki Sueng Choi
Haneul Song
Jungho Cha
Sankaraleengam Alagapan
Nico U. F. Dosenbach
Nico U. F. Dosenbach
Nico U. F. Dosenbach
Nico U. F. Dosenbach
Nico U. F. Dosenbach
Nico U. F. Dosenbach
Evan M. Gordon
Jianxun Ren
Hesheng Liu
Hesheng Liu
Lorraine V. Kalia
Lorraine V. Kalia
Sarah-Anna Hescham
Sarah-Anna Hescham
Sarah-Anna Hescham
Dorian M. Kusyk
Adolfo Ramirez-Zamora
Kelly D. Foote
Michael S. Okun
Joshua K. Wong
author_sort Alfonso Enrique Martinez-Nunez
collection DOAJ
description The Deep Brain Stimulation (DBS) Think Tank XII was held on August 21st to 23rd. This year we showcased groundbreaking advancements in neuromodulation technology, focusing heavily on the novel uses of existing technology as well as next-generation technology. Our keynote speaker shared the vision of using neuro artificial intelligence to predict depression using brain electrophysiology. Innovative applications are currently being explored in stroke, disorders of consciousness, and sleep, while established treatments for movement disorders like Parkinson’s disease are being refined with adaptive stimulation. Neuromodulation is solidifying its role in treating psychiatric disorders such as depression and obsessive-compulsive disorder, particularly for patients with treatment-resistant symptoms. We estimate that 300,000 leads have been implanted to date for neurologic and neuropsychiatric indications. Magnetoencephalography has provided insights into the post-DBS physiological changes. The field is also critically examining the ethical implications of implants, considering the long-term impacts on clinicians, patients, and manufacturers.
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spelling doaj-art-dd594ea7182a4fc6bcbb3ed84accfa102025-08-20T02:10:39ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612025-02-011910.3389/fnhum.2025.15449941544994Proceedings of the 12th annual deep brain stimulation think tank: cutting edge technology meets novel applicationsAlfonso Enrique Martinez-Nunez0Christopher J. Rozell1Simon Little2Huiling Tan3Stephen L. Schmidt4Warren M. Grill5Warren M. Grill6Miroslav Pajic7Dennis A. Turner8Dennis A. Turner9Dennis A. Turner10Coralie de Hemptinne11Andre Machado12Andre Machado13Nicholas D. Schiff14Abbey S. Holt-Becker15Robert S. Raike16Mahsa Malekmohammadi17Mahsa Malekmohammadi18Yagna J. Pathak19Lyndahl Himes20David Greene21Lothar Krinke22Lothar Krinke23Mattia Arlotti24Lorenzo Rossi25Jacob Robinson26Jacob Robinson27Bahne H. Bahners28Bahne H. Bahners29Bahne H. Bahners30Vladimir Litvak31Luka Milosevic32Luka Milosevic33Saadi Ghatan34Saadi Ghatan35Frederic L. W. V. J. Schaper36Michael D. Fox37Nicholas M. Gregg38Cynthia Kubu39James J. Jordano40James J. Jordano41James J. Jordano42Nicola G. Cascella43YoungHoon Nho44Casey H. Halpern45Casey H. Halpern46Helen S. Mayberg47Helen S. Mayberg48Helen S. Mayberg49Ki Sueng Choi50Ki Sueng Choi51Haneul Song52Jungho Cha53Sankaraleengam Alagapan54Nico U. F. Dosenbach55Nico U. F. Dosenbach56Nico U. F. Dosenbach57Nico U. F. Dosenbach58Nico U. F. Dosenbach59Nico U. F. Dosenbach60Evan M. Gordon61Jianxun Ren62Hesheng Liu63Hesheng Liu64Lorraine V. Kalia65Lorraine V. Kalia66Sarah-Anna Hescham67Sarah-Anna Hescham68Sarah-Anna Hescham69Dorian M. Kusyk70Adolfo Ramirez-Zamora71Kelly D. Foote72Michael S. Okun73Joshua K. Wong74Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, United StatesSchool of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, United StatesMovement Disorders and Neuromodulation Centre, University of California San Francisco, San Francisco, CA, United StatesMedical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United KingdomDepartments of Biomedical Engineering, Electrical and Computer Engineering, Neurobiology and Neurosurgery, Duke University and Duke University Medical Center, Durham, NC, United StatesDepartments of Biomedical Engineering, Electrical and Computer Engineering, Neurobiology and Neurosurgery, Duke University and Duke University Medical Center, Durham, NC, United StatesDepartment of Neurobiology, Duke University Medical Center, Durham, NC, United StatesDepartments of Biomedical Engineering, Electrical and Computer Engineering, Neurobiology and Neurosurgery, Duke University and Duke University Medical Center, Durham, NC, United StatesDepartments of Biomedical Engineering, Electrical and Computer Engineering, Neurobiology and Neurosurgery, Duke University and Duke University Medical Center, Durham, NC, United StatesDepartment of Neurobiology, Duke University Medical Center, Durham, NC, United StatesDepartment of Neurosurgery, Duke University Medical Center, Durham, NC, United StatesNorman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, United StatesCenter for Neurological Restoration, Cleveland Clinic, Cleveland, OH, United StatesDepartment of Neurology, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, United States0Weill Cornell Medical College, Feil Family Brain and Mind Research Institute, New York, NY, United States1Restorative Therapies Group Implantables, Research, and Core Technology, Medtronic Inc., Minneapolis, MN, United States1Restorative Therapies Group Implantables, Research, and Core Technology, Medtronic Inc., Minneapolis, MN, United States2Department of Neurosurgery, University of California, Los Angeles, CA, United States3Boston Scientific Neuromodulation, Valencia, CA, United States4Neuromodulation Division, Abbott, Plano, TX, United States4Neuromodulation Division, Abbott, Plano, TX, United States5NeuroPace, Inc., Mountain View, CA, United States6Newronika SpA, Milan, Italy7West Virginia University, Morgantown, WV, United States6Newronika SpA, Milan, Italy6Newronika SpA, Milan, Italy8Department of Bioengineering, Rice University, Houston, TX, United States9Department of Electrical and Computer Engineering, Rice University, Houston, TX, United States0Department of Neurology, Brigham & Women's Hospital, Harvard Medical School, Center for Brain Circuit Therapeutics, Boston, MA, United States1Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany2Department of Neurology, Center for Movement Disorders and Neuromodulation, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany3Wellcome Centre for Human Neuroimaging, UCL Queen Square Institute of Neurology, London, United Kingdom4Clinical and Computational Neuroscience, Krembil Research Institute, University Health Network, Toronto, ON, Canada5Faculty of Medicine, Institute for Neuromodulation and Neurotechnology, University Hospital Tübingen (UKT), University Tübingen, Tübingen, Germany6Department of Neurosurgery, Mount Sinai Medical Center, New York, NY, United States7Department of Neurosurgery, Maria Fareri Children's Hospital, Westchester Medical Center, Valhalla, NY, United States0Department of Neurology, Brigham & Women's Hospital, Harvard Medical School, Center for Brain Circuit Therapeutics, Boston, MA, United States0Department of Neurology, Brigham & Women's Hospital, Harvard Medical School, Center for Brain Circuit Therapeutics, Boston, MA, United States8Department of Neurology, Mayo Clinic, Rochester, MN, United StatesCenter for Neurological Restoration, Cleveland Clinic, Cleveland, OH, United States9Department of Neurology, Georgetown University Medical Center, Washington, DC, United States0Department of Biochemistry, Georgetown University Medical Center, Washington, DC, United States1Neuroethics Studies Program, Georgetown University Medical Center, Washington, DC, United States2Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, United States3Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA, United States3Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA, United States4Department of Surgery, Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA, United States5Nash Family Center for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY, United States6Department of Radiology and Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, NY, United States7Department of Neurology and Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States5Nash Family Center for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY, United States6Department of Radiology and Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, NY, United States5Nash Family Center for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY, United States5Nash Family Center for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesSchool of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, United States8Department of Neurology, Washington University School of Medicine, St. Louis, MO, United States9Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, United States0Department of Psychological & Brain Sciences, Washington University, St. Louis, MO, United States1Department of Biomedical Engineering, Washington University, St. Louis, MO, United States2Program in Occupational Therapy, Washington University, St. Louis, MO, United States3Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, United States4Department of Radiology, Washington University School of Medicine, St. Louis, MO, United States5Changping Laboratory, Beijing, China5Changping Laboratory, Beijing, China6Biomedical Pioneering Innovation Center, Peking University, Beijing, China7Edmond J Safra Program in Parkinson's Disease, Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada8Division of Neurology, Department of Medicine, University of Toronto, Toronto, ON, Canada9School for Mental Health and Neuroscience, Maastricht University, Maastricht, Netherlands0Department of Neurosurgery, Maastricht University Medical Center, Maastricht, Netherlands1Department of Neurosurgery, RWTH Aachen University Hospital, Aachen, GermanyNorman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, United StatesNorman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, United StatesNorman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, United StatesNorman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, United StatesNorman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, United StatesThe Deep Brain Stimulation (DBS) Think Tank XII was held on August 21st to 23rd. This year we showcased groundbreaking advancements in neuromodulation technology, focusing heavily on the novel uses of existing technology as well as next-generation technology. Our keynote speaker shared the vision of using neuro artificial intelligence to predict depression using brain electrophysiology. Innovative applications are currently being explored in stroke, disorders of consciousness, and sleep, while established treatments for movement disorders like Parkinson’s disease are being refined with adaptive stimulation. Neuromodulation is solidifying its role in treating psychiatric disorders such as depression and obsessive-compulsive disorder, particularly for patients with treatment-resistant symptoms. We estimate that 300,000 leads have been implanted to date for neurologic and neuropsychiatric indications. Magnetoencephalography has provided insights into the post-DBS physiological changes. The field is also critically examining the ethical implications of implants, considering the long-term impacts on clinicians, patients, and manufacturers.https://www.frontiersin.org/articles/10.3389/fnhum.2025.1544994/fullneuromodulationdeep brain stimulationParkinson’s diseaseepilepsysleepstroke
spellingShingle Alfonso Enrique Martinez-Nunez
Christopher J. Rozell
Simon Little
Huiling Tan
Stephen L. Schmidt
Warren M. Grill
Warren M. Grill
Miroslav Pajic
Dennis A. Turner
Dennis A. Turner
Dennis A. Turner
Coralie de Hemptinne
Andre Machado
Andre Machado
Nicholas D. Schiff
Abbey S. Holt-Becker
Robert S. Raike
Mahsa Malekmohammadi
Mahsa Malekmohammadi
Yagna J. Pathak
Lyndahl Himes
David Greene
Lothar Krinke
Lothar Krinke
Mattia Arlotti
Lorenzo Rossi
Jacob Robinson
Jacob Robinson
Bahne H. Bahners
Bahne H. Bahners
Bahne H. Bahners
Vladimir Litvak
Luka Milosevic
Luka Milosevic
Saadi Ghatan
Saadi Ghatan
Frederic L. W. V. J. Schaper
Michael D. Fox
Nicholas M. Gregg
Cynthia Kubu
James J. Jordano
James J. Jordano
James J. Jordano
Nicola G. Cascella
YoungHoon Nho
Casey H. Halpern
Casey H. Halpern
Helen S. Mayberg
Helen S. Mayberg
Helen S. Mayberg
Ki Sueng Choi
Ki Sueng Choi
Haneul Song
Jungho Cha
Sankaraleengam Alagapan
Nico U. F. Dosenbach
Nico U. F. Dosenbach
Nico U. F. Dosenbach
Nico U. F. Dosenbach
Nico U. F. Dosenbach
Nico U. F. Dosenbach
Evan M. Gordon
Jianxun Ren
Hesheng Liu
Hesheng Liu
Lorraine V. Kalia
Lorraine V. Kalia
Sarah-Anna Hescham
Sarah-Anna Hescham
Sarah-Anna Hescham
Dorian M. Kusyk
Adolfo Ramirez-Zamora
Kelly D. Foote
Michael S. Okun
Joshua K. Wong
Proceedings of the 12th annual deep brain stimulation think tank: cutting edge technology meets novel applications
Frontiers in Human Neuroscience
neuromodulation
deep brain stimulation
Parkinson’s disease
epilepsy
sleep
stroke
title Proceedings of the 12th annual deep brain stimulation think tank: cutting edge technology meets novel applications
title_full Proceedings of the 12th annual deep brain stimulation think tank: cutting edge technology meets novel applications
title_fullStr Proceedings of the 12th annual deep brain stimulation think tank: cutting edge technology meets novel applications
title_full_unstemmed Proceedings of the 12th annual deep brain stimulation think tank: cutting edge technology meets novel applications
title_short Proceedings of the 12th annual deep brain stimulation think tank: cutting edge technology meets novel applications
title_sort proceedings of the 12th annual deep brain stimulation think tank cutting edge technology meets novel applications
topic neuromodulation
deep brain stimulation
Parkinson’s disease
epilepsy
sleep
stroke
url https://www.frontiersin.org/articles/10.3389/fnhum.2025.1544994/full
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