Leptomeningeal carcinomatosis can be presenting manifestation of breast carcinoma
Introduction. Leptomeningeal carcinomatosis (LC) is a serious complication occuring in solid cancer patients with rather poor prognosis. Case report. We presented a 47-yearold woman with the 6-month history of diffuse headache, nausea and visual obscuration. Initially, clinical status and...
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2016-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2016/0042-84501500118M.pdf |
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| author | Mandić-Stojmenović Gorana Pavlović Aleksandra M. Skender-Gazibara Milica Grujičić Danica Radojičić Aleksandra Čovičković-Šternić Nadežda |
| author_facet | Mandić-Stojmenović Gorana Pavlović Aleksandra M. Skender-Gazibara Milica Grujičić Danica Radojičić Aleksandra Čovičković-Šternić Nadežda |
| author_sort | Mandić-Stojmenović Gorana |
| collection | DOAJ |
| description | Introduction. Leptomeningeal carcinomatosis (LC) is a serious complication
occuring in solid cancer patients with rather poor prognosis. Case report.
We presented a 47-yearold woman with the 6-month history of diffuse
headache, nausea and visual obscuration. Initially, clinical status and
brain magnetic resonance imaging (MRI) indicated syndrome of idiopathic
intracranial hypertension. Due to clinical progression and high papillary
stasis, cerebrospinal fluid (CSF) examination was performed only after
ventriculoperitoneal shunt was implanted. This led to a significant although
transient clinical improvement. Futher investigations led to the diagnosis
of invasive lobular breast carcinoma and repeated CSF analysis revealed
malignant breast carcinoma cells. In this case LC was an initial
presentation of a malignant disease. Conclusion. In the presence of a high
clinical suspicion of LC, in spite of initially negative findings, a
clinician should persist in repeating relevant tests, such are MRI with
larger amounts of gadolinium and high-volume cytological CSF analyses in
order to make the diagnosis. [Projekat Ministarstva nauke Republike Srbije,
br. 175022] |
| format | Article |
| id | doaj-art-dd522f0818c143e0833246f28b5e8880 |
| institution | OA Journals |
| issn | 0042-8450 2406-0720 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-dd522f0818c143e0833246f28b5e88802025-08-20T02:04:20ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502406-07202016-01-0173329329510.2298/VSP120814118M0042-84501500118MLeptomeningeal carcinomatosis can be presenting manifestation of breast carcinomaMandić-Stojmenović Gorana0Pavlović Aleksandra M.1Skender-Gazibara Milica2Grujičić Danica3Radojičić Aleksandra4Čovičković-Šternić Nadežda5Faculty of Medicine, Neurology Clinic, BelgradeFaculty of Medicine, Neurology Clinic, BelgradeFaculty of Medicine, Institute of Pathology, BelgradeFaculty of Medicine, Neurosurgery Clinic, BelgradeFaculty of Medicine, Neurology Clinic, BelgradeFaculty of Medicine, Neurology Clinic, BelgradeIntroduction. Leptomeningeal carcinomatosis (LC) is a serious complication occuring in solid cancer patients with rather poor prognosis. Case report. We presented a 47-yearold woman with the 6-month history of diffuse headache, nausea and visual obscuration. Initially, clinical status and brain magnetic resonance imaging (MRI) indicated syndrome of idiopathic intracranial hypertension. Due to clinical progression and high papillary stasis, cerebrospinal fluid (CSF) examination was performed only after ventriculoperitoneal shunt was implanted. This led to a significant although transient clinical improvement. Futher investigations led to the diagnosis of invasive lobular breast carcinoma and repeated CSF analysis revealed malignant breast carcinoma cells. In this case LC was an initial presentation of a malignant disease. Conclusion. In the presence of a high clinical suspicion of LC, in spite of initially negative findings, a clinician should persist in repeating relevant tests, such are MRI with larger amounts of gadolinium and high-volume cytological CSF analyses in order to make the diagnosis. [Projekat Ministarstva nauke Republike Srbije, br. 175022]http://www.doiserbia.nb.rs/img/doi/0042-8450/2016/0042-84501500118M.pdfbreast neoplasmsneoplasm metastasismeningealneoplasmsdiagnosisdifferential |
| spellingShingle | Mandić-Stojmenović Gorana Pavlović Aleksandra M. Skender-Gazibara Milica Grujičić Danica Radojičić Aleksandra Čovičković-Šternić Nadežda Leptomeningeal carcinomatosis can be presenting manifestation of breast carcinoma Vojnosanitetski Pregled breast neoplasms neoplasm metastasis meningealneoplasms diagnosis differential |
| title | Leptomeningeal carcinomatosis can be presenting manifestation of breast carcinoma |
| title_full | Leptomeningeal carcinomatosis can be presenting manifestation of breast carcinoma |
| title_fullStr | Leptomeningeal carcinomatosis can be presenting manifestation of breast carcinoma |
| title_full_unstemmed | Leptomeningeal carcinomatosis can be presenting manifestation of breast carcinoma |
| title_short | Leptomeningeal carcinomatosis can be presenting manifestation of breast carcinoma |
| title_sort | leptomeningeal carcinomatosis can be presenting manifestation of breast carcinoma |
| topic | breast neoplasms neoplasm metastasis meningealneoplasms diagnosis differential |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2016/0042-84501500118M.pdf |
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