Is Schistosomiasis a Risk Factor for Bladder Cancer? Evidence-Based Facts
Background. Globally, approximately 20% of malignancy are caused by infection. Schistosoma infection is a major cause of bladder in most part of Africa. In 2018 alone, there were approximately 549,393 new cases and 199,922 deaths from bladder cancer. The presence of Schistosoma ova in the venous ple...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | Journal of Tropical Medicine |
| Online Access: | http://dx.doi.org/10.1155/2020/8270810 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849434868669218816 |
|---|---|
| author | Mohamed Jalloh Ayun Cassell Thierno Diallo Omar Gaye Medina Ndoye Mouhamadou M. Mbodji Mahamat Ali Mahamat Abdourahmane Diallo Cherif Dial Issa Labou Lamine Niang Serigne M. Gueye |
| author_facet | Mohamed Jalloh Ayun Cassell Thierno Diallo Omar Gaye Medina Ndoye Mouhamadou M. Mbodji Mahamat Ali Mahamat Abdourahmane Diallo Cherif Dial Issa Labou Lamine Niang Serigne M. Gueye |
| author_sort | Mohamed Jalloh |
| collection | DOAJ |
| description | Background. Globally, approximately 20% of malignancy are caused by infection. Schistosoma infection is a major cause of bladder in most part of Africa. In 2018 alone, there were approximately 549,393 new cases and 199,922 deaths from bladder cancer. The presence of Schistosoma ova in the venous plexus of the bladder induces a cascade of inflammation causing significant tissue damage and granulomatous changes. Methodology. A literature review was conducted from 1995 to 2019 using PubMed, Google Scholar, African Journal Online, and Google databases. Relevant data on the association of “Schistosomiasis and Bladder cancer” in sub-Saharan Africa (SSA) were retrieved. Evidence Synthesis. Results from research using animal models to establish the carcinogenesis of Schistosoma and bladder cancer have been helpful but inconclusive. Immunoregulatory cytokines and genetic marker have been identified to play a role in the pathogenesis. In some parts of sub-Saharan Africa, there has been close association of squamous cell carcinoma and histological evidence of Schistosoma ova. Conclusion. There are some data to support the association between schistosomiasis and bladder cancer in sub-Saharan Africa. However, these have been limited by their design and may not sufficiently establish carcinogenesis. There is a need for more genomic and molecular research to better characterize S. haematobium and its effects on the bladder. Such goal will contribute immensely to Schistosoma bladder cancer prevention and control. |
| format | Article |
| id | doaj-art-dd4c45a32f194e549709675d79f304bb |
| institution | Kabale University |
| issn | 1687-9686 1687-9694 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Tropical Medicine |
| spelling | doaj-art-dd4c45a32f194e549709675d79f304bb2025-08-20T03:26:30ZengWileyJournal of Tropical Medicine1687-96861687-96942020-01-01202010.1155/2020/82708108270810Is Schistosomiasis a Risk Factor for Bladder Cancer? Evidence-Based FactsMohamed Jalloh0Ayun Cassell1Thierno Diallo2Omar Gaye3Medina Ndoye4Mouhamadou M. Mbodji5Mahamat Ali Mahamat6Abdourahmane Diallo7Cherif Dial8Issa Labou9Lamine Niang10Serigne M. Gueye11Service d’Urologie, Hopital General de Grand Yoff, Dakar, SenegalService d’Urologie, Hopital General de Grand Yoff, Dakar, SenegalService d’Urologie, Hopital General de Grand Yoff, Dakar, SenegalService d’Urologie, Hopital General de Grand Yoff, Dakar, SenegalService d’Urologie, Hopital General de Grand Yoff, Dakar, SenegalService d’Urologie, Hopital General de Grand Yoff, Dakar, SenegalCentre Hospitalo-Universitaire de Référence Nationale, N’jamena, ChadService d’Urologie, Hopital General de Grand Yoff, Dakar, SenegalService d’Urologie, Hopital General de Grand Yoff, Dakar, SenegalService d’Urologie, Hopital General de Grand Yoff, Dakar, SenegalService d’Urologie, Hopital General de Grand Yoff, Dakar, SenegalService d’Urologie, Hopital General de Grand Yoff, Dakar, SenegalBackground. Globally, approximately 20% of malignancy are caused by infection. Schistosoma infection is a major cause of bladder in most part of Africa. In 2018 alone, there were approximately 549,393 new cases and 199,922 deaths from bladder cancer. The presence of Schistosoma ova in the venous plexus of the bladder induces a cascade of inflammation causing significant tissue damage and granulomatous changes. Methodology. A literature review was conducted from 1995 to 2019 using PubMed, Google Scholar, African Journal Online, and Google databases. Relevant data on the association of “Schistosomiasis and Bladder cancer” in sub-Saharan Africa (SSA) were retrieved. Evidence Synthesis. Results from research using animal models to establish the carcinogenesis of Schistosoma and bladder cancer have been helpful but inconclusive. Immunoregulatory cytokines and genetic marker have been identified to play a role in the pathogenesis. In some parts of sub-Saharan Africa, there has been close association of squamous cell carcinoma and histological evidence of Schistosoma ova. Conclusion. There are some data to support the association between schistosomiasis and bladder cancer in sub-Saharan Africa. However, these have been limited by their design and may not sufficiently establish carcinogenesis. There is a need for more genomic and molecular research to better characterize S. haematobium and its effects on the bladder. Such goal will contribute immensely to Schistosoma bladder cancer prevention and control.http://dx.doi.org/10.1155/2020/8270810 |
| spellingShingle | Mohamed Jalloh Ayun Cassell Thierno Diallo Omar Gaye Medina Ndoye Mouhamadou M. Mbodji Mahamat Ali Mahamat Abdourahmane Diallo Cherif Dial Issa Labou Lamine Niang Serigne M. Gueye Is Schistosomiasis a Risk Factor for Bladder Cancer? Evidence-Based Facts Journal of Tropical Medicine |
| title | Is Schistosomiasis a Risk Factor for Bladder Cancer? Evidence-Based Facts |
| title_full | Is Schistosomiasis a Risk Factor for Bladder Cancer? Evidence-Based Facts |
| title_fullStr | Is Schistosomiasis a Risk Factor for Bladder Cancer? Evidence-Based Facts |
| title_full_unstemmed | Is Schistosomiasis a Risk Factor for Bladder Cancer? Evidence-Based Facts |
| title_short | Is Schistosomiasis a Risk Factor for Bladder Cancer? Evidence-Based Facts |
| title_sort | is schistosomiasis a risk factor for bladder cancer evidence based facts |
| url | http://dx.doi.org/10.1155/2020/8270810 |
| work_keys_str_mv | AT mohamedjalloh isschistosomiasisariskfactorforbladdercancerevidencebasedfacts AT ayuncassell isschistosomiasisariskfactorforbladdercancerevidencebasedfacts AT thiernodiallo isschistosomiasisariskfactorforbladdercancerevidencebasedfacts AT omargaye isschistosomiasisariskfactorforbladdercancerevidencebasedfacts AT medinandoye isschistosomiasisariskfactorforbladdercancerevidencebasedfacts AT mouhamadoummbodji isschistosomiasisariskfactorforbladdercancerevidencebasedfacts AT mahamatalimahamat isschistosomiasisariskfactorforbladdercancerevidencebasedfacts AT abdourahmanediallo isschistosomiasisariskfactorforbladdercancerevidencebasedfacts AT cherifdial isschistosomiasisariskfactorforbladdercancerevidencebasedfacts AT issalabou isschistosomiasisariskfactorforbladdercancerevidencebasedfacts AT lamineniang isschistosomiasisariskfactorforbladdercancerevidencebasedfacts AT serignemgueye isschistosomiasisariskfactorforbladdercancerevidencebasedfacts |