Identifying critical States of complex diseases by local network Wasserstein distance

Abstract Complex diseases often undergo abrupt transitions from pre-disease to disease states, with the pre-disease state is typically unstable but potentially reversible through timely intervention. Detecting these critical transitions is crucial. We propose a model-free method, Local Network Wasse...

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Bibliographic Details
Main Authors: Changchun Liu, Pingjun Hou, Lin Feng
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
Online Access:https://doi.org/10.1038/s41598-025-94521-0
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