Intestinal Type Gastric Cancer and Gastric Adenoma
Gastric adenoma (dysplasia) is a precursor for gastric cancer and is closely associated with intestinal type gastric cancer. Thus, accurate diagnosis and proper management of gastric adenoma are extremely critical for preventing gastric cancer. The revised Vienna and World Health Organization classi...
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Korean College of Helicobacter and Upper Gastrointestinal Research
2022-03-01
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| Series: | The Korean Journal of Helicobacter and Upper Gastrointestinal Research |
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| Online Access: | http://helicojournal.org/upload/pdf/kjhugr-2021-0054.pdf |
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| author | Cheal Wung Huh Sang Kil Lee |
| author_facet | Cheal Wung Huh Sang Kil Lee |
| author_sort | Cheal Wung Huh |
| collection | DOAJ |
| description | Gastric adenoma (dysplasia) is a precursor for gastric cancer and is closely associated with intestinal type gastric cancer. Thus, accurate diagnosis and proper management of gastric adenoma are extremely critical for preventing gastric cancer. The revised Vienna and World Health Organization classifications have categorized gastric adenomas into two types: high-grade and low-grade dysplasia. High-grade dysplasia requires endoscopic resection due to synchronous carcinoma or the high risk of progression to carcinoma. Although the treatment for low-grade dysplasia remains controversial, endoscopic resection is also recommended due to the potential of progression to carcinomas and the unrevealed histologic discrepancies between forceps biopsy and endoscopic specimens. According to the Lauren classification, gastric cancer is categorized into three histologic types: intestinal, diffuse, and mixed types. Intestinal and diffuse types show a distinct difference in their clinical and epidemiological features. The intestinal type, in its pathogenesis, follows the cascade of non-atrophic gastritis, atrophic gastritis, intestinal metaplasia, adenoma, and intramucosal neoplasia (correa cascade). It tends to appear in older ages than diffuse type and show some predominance in the distal portion of the stomach. It is more common in males and is often associated with environmental factors. In this review, the current knowledge of gastric adenoma and intestinal type gastric cancer, together with relevant diagnostic and therapeutic strategies, is discussed. |
| format | Article |
| id | doaj-art-dd4958e224f34aa6b91d5fb6f276d458 |
| institution | Kabale University |
| issn | 1738-3331 |
| language | English |
| publishDate | 2022-03-01 |
| publisher | Korean College of Helicobacter and Upper Gastrointestinal Research |
| record_format | Article |
| series | The Korean Journal of Helicobacter and Upper Gastrointestinal Research |
| spelling | doaj-art-dd4958e224f34aa6b91d5fb6f276d4582025-08-20T03:58:50ZengKorean College of Helicobacter and Upper Gastrointestinal ResearchThe Korean Journal of Helicobacter and Upper Gastrointestinal Research1738-33312022-03-0122151010.7704/kjhugr.2021.0054713Intestinal Type Gastric Cancer and Gastric AdenomaCheal Wung Huh0Sang Kil Lee1Division of Gastroenterology, Yongin Severance Hospital, Yonsei University College of Medicine, Seoul, KoreaDivision of Gastroenterology, Severance Hospital, Yonsei University College of Medicine, Seoul, KoreaGastric adenoma (dysplasia) is a precursor for gastric cancer and is closely associated with intestinal type gastric cancer. Thus, accurate diagnosis and proper management of gastric adenoma are extremely critical for preventing gastric cancer. The revised Vienna and World Health Organization classifications have categorized gastric adenomas into two types: high-grade and low-grade dysplasia. High-grade dysplasia requires endoscopic resection due to synchronous carcinoma or the high risk of progression to carcinoma. Although the treatment for low-grade dysplasia remains controversial, endoscopic resection is also recommended due to the potential of progression to carcinomas and the unrevealed histologic discrepancies between forceps biopsy and endoscopic specimens. According to the Lauren classification, gastric cancer is categorized into three histologic types: intestinal, diffuse, and mixed types. Intestinal and diffuse types show a distinct difference in their clinical and epidemiological features. The intestinal type, in its pathogenesis, follows the cascade of non-atrophic gastritis, atrophic gastritis, intestinal metaplasia, adenoma, and intramucosal neoplasia (correa cascade). It tends to appear in older ages than diffuse type and show some predominance in the distal portion of the stomach. It is more common in males and is often associated with environmental factors. In this review, the current knowledge of gastric adenoma and intestinal type gastric cancer, together with relevant diagnostic and therapeutic strategies, is discussed.http://helicojournal.org/upload/pdf/kjhugr-2021-0054.pdfadenomaintestinal type gastric cancerlauren classificationstomach |
| spellingShingle | Cheal Wung Huh Sang Kil Lee Intestinal Type Gastric Cancer and Gastric Adenoma The Korean Journal of Helicobacter and Upper Gastrointestinal Research adenoma intestinal type gastric cancer lauren classification stomach |
| title | Intestinal Type Gastric Cancer and Gastric Adenoma |
| title_full | Intestinal Type Gastric Cancer and Gastric Adenoma |
| title_fullStr | Intestinal Type Gastric Cancer and Gastric Adenoma |
| title_full_unstemmed | Intestinal Type Gastric Cancer and Gastric Adenoma |
| title_short | Intestinal Type Gastric Cancer and Gastric Adenoma |
| title_sort | intestinal type gastric cancer and gastric adenoma |
| topic | adenoma intestinal type gastric cancer lauren classification stomach |
| url | http://helicojournal.org/upload/pdf/kjhugr-2021-0054.pdf |
| work_keys_str_mv | AT chealwunghuh intestinaltypegastriccancerandgastricadenoma AT sangkillee intestinaltypegastriccancerandgastricadenoma |