Generation and characterization of CRISPR-Cas9-mediated XPC gene knockout in human skin cells

Generation and characterization of CRISPR-Cas9-mediated XPC gene knockout in human skin cells

Abstract Xeroderma pigmentosum group C (XPC) is a versatile protein crucial for sensing DNA damage in the global genome nucleotide excision repair (GG-NER) pathway. This pathway is vital for mammalian cells, acting as their essential approach for repairing DNA lesions stemming from interactions with...

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Bibliographic Details
Main Authors: Ali Nasrallah, Hamid-Reza Rezvani, Farah Kobaisi, Ahmad Hammoud, Jérôme Rambert, Jos P. H. Smits, Eric Sulpice, Walid Rachidi
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Subjects:
Skin
CRISPR-Cas9
XP-C disease
DNA damage
UV irradiation
Online Access:https://doi.org/10.1038/s41598-024-81675-6
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