Relationship Between Leptin and Heart Failure: A Meta-Analysis
Background: Heart failure (HF) is a diverse and potentially fatal condition affecting more than 60 million people worldwide. Previous studies have identified a close relationship between leptin levels and HF, and that leptin levels in patients with HF are higher than those in healthy individuals. Ho...
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| Format: | Article |
| Language: | English |
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Ubiquity Press
2025-05-01
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| Series: | Global Heart |
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| Online Access: | https://account.globalheartjournal.com/index.php/up-j-gh/article/view/1434 |
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| author | Xin Sun Caihong Xin Jiayi Yao Hongli Wang |
| author_facet | Xin Sun Caihong Xin Jiayi Yao Hongli Wang |
| author_sort | Xin Sun |
| collection | DOAJ |
| description | Background: Heart failure (HF) is a diverse and potentially fatal condition affecting more than 60 million people worldwide. Previous studies have identified a close relationship between leptin levels and HF, and that leptin levels in patients with HF are higher than those in healthy individuals. However, some studies have reported inconsistent results. Therefore, the association between leptin levels and HF remains controversial. Methods: A literature search was conducted on the Web of Science, Wiley Online Library, Embase, and PubMed databases. The title or abstract search term ‘leptin’ was used in combination with ‘heart failure’ and ‘HF’. Meta-analysis results were reported as standardized mean differences (SMD) with corresponding 95% confidence intervals (CI). Results: Eighteen studies comprising 1149 patients with HF and 622 healthy controls were included in the meta-analysis. Leptin levels in patients with HF were significantly higher than those in healthy individuals (SMD, 0.54; 95% CI [0.15, 0.93]). Conclusions: To our knowledge, this systematic review is the first to evaluate the relationship between leptin and HF. Determining the role of leptin in HF will significantly contribute to its diagnosis and treatment. |
| format | Article |
| id | doaj-art-dd3b114d0a4a4744b3bdd67d6505d471 |
| institution | OA Journals |
| issn | 2211-8179 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Ubiquity Press |
| record_format | Article |
| series | Global Heart |
| spelling | doaj-art-dd3b114d0a4a4744b3bdd67d6505d4712025-08-20T02:33:20ZengUbiquity PressGlobal Heart2211-81792025-05-01201444410.5334/gh.14341415Relationship Between Leptin and Heart Failure: A Meta-AnalysisXin Sun0https://orcid.org/0000-0003-1409-4661Caihong Xin1https://orcid.org/0009-0006-4482-5858Jiayi Yao2Hongli Wang3https://orcid.org/0000-0002-4506-306XDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of Soochow University, SuzhouDepartment of Endocrinology and Metabolism, The Fourth People’s Hospital of Soochow University, ShenyangDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of Soochow University, SuzhouDepartment of Cardiology, The Second Affiliated Hospital of Dalian Medical University, DalianBackground: Heart failure (HF) is a diverse and potentially fatal condition affecting more than 60 million people worldwide. Previous studies have identified a close relationship between leptin levels and HF, and that leptin levels in patients with HF are higher than those in healthy individuals. However, some studies have reported inconsistent results. Therefore, the association between leptin levels and HF remains controversial. Methods: A literature search was conducted on the Web of Science, Wiley Online Library, Embase, and PubMed databases. The title or abstract search term ‘leptin’ was used in combination with ‘heart failure’ and ‘HF’. Meta-analysis results were reported as standardized mean differences (SMD) with corresponding 95% confidence intervals (CI). Results: Eighteen studies comprising 1149 patients with HF and 622 healthy controls were included in the meta-analysis. Leptin levels in patients with HF were significantly higher than those in healthy individuals (SMD, 0.54; 95% CI [0.15, 0.93]). Conclusions: To our knowledge, this systematic review is the first to evaluate the relationship between leptin and HF. Determining the role of leptin in HF will significantly contribute to its diagnosis and treatment.https://account.globalheartjournal.com/index.php/up-j-gh/article/view/1434leptinheart failurehf |
| spellingShingle | Xin Sun Caihong Xin Jiayi Yao Hongli Wang Relationship Between Leptin and Heart Failure: A Meta-Analysis Global Heart leptin heart failure hf |
| title | Relationship Between Leptin and Heart Failure: A Meta-Analysis |
| title_full | Relationship Between Leptin and Heart Failure: A Meta-Analysis |
| title_fullStr | Relationship Between Leptin and Heart Failure: A Meta-Analysis |
| title_full_unstemmed | Relationship Between Leptin and Heart Failure: A Meta-Analysis |
| title_short | Relationship Between Leptin and Heart Failure: A Meta-Analysis |
| title_sort | relationship between leptin and heart failure a meta analysis |
| topic | leptin heart failure hf |
| url | https://account.globalheartjournal.com/index.php/up-j-gh/article/view/1434 |
| work_keys_str_mv | AT xinsun relationshipbetweenleptinandheartfailureametaanalysis AT caihongxin relationshipbetweenleptinandheartfailureametaanalysis AT jiayiyao relationshipbetweenleptinandheartfailureametaanalysis AT hongliwang relationshipbetweenleptinandheartfailureametaanalysis |